Department of Clinical Pharmaceutics
Department
Professor | Toru Maruyama tomaru(at mark)gpo.kumamoto-u.ac.jp |
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Associate Professor | Hiroshi Watanabe hnabe(at mark)kumamoto-u.ac.jp |
Assistant Professor | Yu ishima y-ishima(at mark)kumamoto-u.ac.jp |
Research themes
[Names and Summaries of Research Projects]
- I. Research Related to In-Vivo Movement Control Mechanisms of Human Serum Albumin (HSA) and Clinical Application Recombinant HSA Formulas
- I-1. Structures of In-Vivo HSA and Drug Bonding Changes During Poor Health
- I-2. Drug Delivery Systems Using Mutant and Polymeric HSA
- I-3. Kinetic and Pharmacodynamic Evaluation of HSA-Redox Protein Fusions
- I-4. Creation of Wound Medicines (Tissue Preservation Liquids, Antibacterials) Using the Pleiotropic Bioactivity of S-Nitrosylated HSA
- I-5. Development of Molecular Albumin Absorbent Recirculation System (MARS) Using Toxin Capturing HSA Mutations
- II. Elucidation of the Biological Functions and Analysis of the In-Vivo Pathological Characteristics of α1 Acid Glycoprotein (AGP)
- II-1. Mapping of Medical Binding Sites in AGP Molecules Using Linear Crystallography
- II-2. Elucidation of the Pharmacokinetics and Molecular Mechanisms for Anti-Inflammatory and Immunoregulatory Actions of AGP
- II-3. Analysis of the Bioactivity of and Creation of Wound Medicines Using S-Nitrosylated AGP
- III. Research Related to the Analysis of Pharmacokinetic Mobilizing Factors in Pathological Conditions and Clinical Applications Thereof
- III-1. Elucidation of Molecular Structures Related to Tissue Migration and Redox Properties of Uremic Substances
- III-2. Analysis of Expression Variation of Pharmacokinetic Regulatory Proteins During Poor Health
- III-3. Elucidation of New Signal Transduction Mechanisms Introduced Through Nitration Reactions During Illness
- IV. Pharmacokinetic Analysis of the Characteristics of Artificial Blood Substitutes and Their Applications in Inflammatory Diseases
- IV-1. Kinetic and Pharmacodynamic Evaluation of Hemoglobin Endoplasmic Reticulum as an Artificial Oxygen Carrier
- IV-2. Kinetic and Pharmacodynamic Evaluation of H12-ADP Liposomes as Artificial Platelets
- V. Evaluation of Antioxidant Effects of Drugs and the Basic Construction of New Treatment Strategies Against Oxidation Stress Diseases
- V-1. Evaluation of Antioxidant Effects and Elucidation of Mechanisms of Drugs Using Biomarkers
- V-2. Quantitative Evaluation of Oxidation Stress During Illness and Evaluation of the Utility of Antioxidant Treatments