Department of Environmental and Molecular Health Sciences

Department

Professor Shogo Misumi
Assistant Professor Fumio Soeda

Research themes

[Names and Summaries of Research Projects]

  1. I. Creation of Mucous Membrane Vaccines (HIV, Influenza, etc.)
    • Basic Research in the Creation of Intestinal Mucosa Immunostimulant and M Cell Targeting Agents
    • Basic Research in the Creation of HIV Mucous Membrane Vaccines
    • Basic Research of Nasal Influenza Vaccines
  2. II. Development of Radical Treatments for HIV
    • Basic Research in Development of Radical HIV Treatment Methods using Moonlight Protein GADPH as a Mechanism for Inhibiting the HIV Reverse Transcription Process
    • Basic Research in the Elucidation of the HIV Elementary Shedding Process and Radical HIV Treatment Methods
    • Basic Research in the Elucidation of the Role of HIV p2 peptides in the Post-Entry Stage
    • Proteome Analysis of HIV Particles
  3. III. Basic Research of the Replication Mechanism of HIV-1
    • Cellular and Molecular Biology Research of HIV Infection and Protein Myristoylation
    • Research of the Biological Significance of HIV-1 Infection and N-myristoyltransferase (NMT1, NMT2)
    p13-01_t.jpg
    [Fullsize Image]

    Illustrated above: Because HIV replicates using numerous host factors, we seek to understand this process, and connect this knowledge to drug discovery.

  4. IV. Development of Improved Physiological and Pharmacological Medicine for Brainstem Reflexes (Coughing and Urination)
    • Physiological and Pharmacological Research of the Cough Reflex
      1. 1-1. Research of the Action Mechanisms of Central Antitissue
      2. 1-2. Research of the Mechanism of Peripheral Manifestations of Coughing Onset
      3. 1-3. Research in Activity Evaluation and Action Mechanisms of New Antitussive Drugs
      4. 1-4. Research of the Role of GIPK Channels in the Onset of Antitussive Drug Action
      5. 1-5. Elucidation of Molecular Mechanisms of GIPK Channel Regulators
      6. 1-6. Determination of the Necessary Structure for Manifestations of GIPK Channel Control and Exploration of New Active Substances
    • Physiological and Pharmacological Research of the Urination Reflex
      1. 2-1. Research of the Role of Glycine Receptors in the Central Nervous Signal Transduction of the Urination Reflex
      2. 2-2. Research of Signal Transduction of the Urination Reflex in Brain Disease Models
      3. 2-3. Fundamental Research Related to the Development of Dysuria Remedies
      4. 2-4. Research Related to the Role of GRIK Channels in the Manifestation of Dysuria
  5. V. Research of Remedies for Higher Brain Dysfunction


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