Department of Clinical Chemistry and Informatics

Department

Professor Tetsumi Irie
Associate Professor Mitsuru Irikura
Assistant Professor Yoichi Ishitsuka

Research themes

[Names and Summaries of Research Projects]

  1. I. Research Related to Optimal Drug Dosage based on Pathological and Physiological Information
    1. I-1. Research Related to Optimization of Drug Treatments for Newborns
    2. I-2. Pharmacokinetic and Clinical Pharmacological Research of Doxapram Treatments for Apnea Paroxysm in Low Birth Weight Infants
    3. I-3. Clinical Research of Metabolic Changes Caused by Theophylline in Low Birth Weight Infants
    4. I-4. Pharmaceutical Initiatives in Improving QOL for Patients in Home Healthcare
    5. I-5. Research of Optimizing Prescription of Adult Acetaminophen Suppositories
    6. I-6. Questionnaire Research of Formulation of Children's Medicine
    7. I-7. Using Pharmaceutical Approaches for Analysis of Formulation Information of Antidiabetic Drugs and Systems for Drug Administration Guidance Methods
    8. I-8. Translational Research of Treatments for Niemann-Pick Disease Type C Using Cyclic Oligosaccharide
    9. I-9. System Construction for Optimal Medicine Use in Insurance Pharmacies
  2. II. Research in the Utility Evaluation of Cell Activators
    1. II-1. Utility Evaluation of Pyruvic Acid as an Internal Organ and Cell Activator
    2. II-2. Research of Healing Acceleration Effects of Phosphoenolpyruvate on Diabetic Skin Ulcers
    3. II-3. Research in Improving Procedures for the Storage of the Sperm of Genetically Altered Mice
  3. III. Research Related to Elucidation of the Pathology of Critical Care Diseases and Development of New Treatment Methods
    1. III-1. Research Related to the Development of Treatments for and the Elucidation of the Pathology of Acute Respiratory Distress Syndrome (ARDS)
    2. III-2. Investigation of Central Nervous Injury Caused by Various Respiratory Stimulants in Animal Models of Hypoxia
    3. III-3. Research Related to Treatment Development and Pathology Elucidation of Drug-Included Liver Damage
  4. IV. Other Research
    1. IV-1. Fundamental Research Related to Optimal Prescription of Topically Applied Vitamin C and E Derivative Drugs
    2. IV-2. Fundamental Research Related to Intracellular Lipid Transmission and Metabolic Control Using Cyclic Oligosaccharide

In the treatment of Apnea Paroxysm, which occurs frequently in low birth weight infants, theophylline, which is not well-suited for the treatment, and doxapram, which is contraindicated in children, are used in treating newborns. Our laboratory, as a member of the newborn clinical pharmaceutical network, working with other newborn care facilities throughout Japan, is performing population pharmacokinetic analysis of the use of these drugs on infants and, using the pharmacokinetic parameters found from the results, is conducting clinical research towards the ends of constructing a system of optimal dosage design for individual child patients. Acute respiratory distress syndrome (ARDS) is a serious illness with a high morality rate caused by lung damage due to advanced pulmonary vascular permeability, yet there are almost no effective treatments against it. Therefore, we are conducting research to elucidate the pathology of ARDS and develop treatments or preventative medicine, using oleic acid induced lung damage cases as a model for the pathology of ARDS.

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Reduction of Apnea Paroxysm in Low Birth Weight Infants Using Optimal Administration of Theophylline



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