Departments

Department

Research themes

[Names and Summaries of Research Projects]

1. I. Research of Molecular Engineering of Useful Antibodies for Developments in Drug Discovery, Pathology Analysis, and Treatment Techniques
   1. Analysis of the Antigen Recognition Mechanisms of Antibodies
   2. Development of Highly Specific Recombinant Monoclonal Antibodies for Small Antigens
   3. Development of Functional Small Antibodies
2. II. Functional Analysis of Proteins Involved in DNA Replication and Repair
   1. Research of the Interactions between DNA and Protein Molecules
   2. Structural and Functional Analysis of Proliferating Cell Nuclear Antigens (PCNA) which Function as Molecular Clamps
   3. Structural and Functional Analysis of Specific Endonuclease (FEN1) with Branching Structures (5'-flap DNA)
3. III. Analysis of Interactions between Chromatin Remodeling Factor Molecules

We are developing research with the aim of fabricating functional molecules for use in the development of drug discovery, pathophysiological analysis, and treatment methods based on the results of analyses of specific interactions between protein and nucleic acid biomolecules. Specifically, using protein engineering methods and synthesized low molecular weight compounds, we conduct (1) analysis of the antigen recognition mechanisms of antibodies and the development of functional recombinant antibodies, and (2) structural and functional analysis of proteins involved in DNA replication and DNA repair. Our knowledge and technology related to biochemistry, physical chemistry, analytical chemistry, molecular biology, bio-organic chemistry, bio-inorganic chemistry, etc., is firmly grounded in a strong foundation in research and education.

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