Department of Bioorganic Medicinal Chemistry

Department

Professor Masami Ohtsuka
Assistant Professor Yoshinari Okamoto

Research themes

[Names and Summaries of Research Projects]

  • Research in Synthesis of Artificial and Natural Bioactive Compounds
    1. Design, Synthesis, and Functional Analysis of Inositol Phosphate Derivatives that Target PH Domain Proteins and IP3 Receptors
    2. Design, Synthesis, and Functional Analysis of Artificial Compounds that Target Zinc-Containing Proteins
    3. Design, Synthesis, and Functional Analysis of New Metal Chelators
    4. Design, Synthesis, and Functional Analysis of Compounds to Inhibit the Functionality of Transcription Factor NF-kB
    5. Design, Synthesis, and Functional Analysis of Medicine that Targets the Brain
  • Academic Research of the HIV Molecular Virus
    1. Creation of HIV-1 Gag-Targeting Inhibitors
    2. Creation of Anti-HIV Host Factor-Controlling Compounds
    3. Functional Analysis of HIV Vpr/Vpx

At our department, we conduct design, synthesis, and functional analysis of chemical compounds with bioactive properties such as the following:

  1. Synthesis and Design of Inositol Phosphate Derivatives and Other Artificial Compounds Active in Intracellular Signal Transduction
  2. Design and Synthesis of Cancer-Fighting Drugs Targeting Various Molecules Such as Zinc-Containing Protease or Transcription Factor NFkB
  3. Design and Synthesis of New DNA Cutting Artificial Compounds
  4. Design and Synthesis of Medicine Targeting the Brain
  5. Academic Research of the HIV Molecular Virus Related to HIV-1 Vif Proteins
  6. Elucidation of Mechanisms of Replication Control of HIV and Creation of Related HIV Inhibitors