Department of Clinical Pharmaceutics

Department

Professor Toru Maruyama
Associate Professor Hiroshi Watanabe
Assistant Professor Yu ishima

Research themes

[Names and Summaries of Research Projects]

  1. I. Research Related to In-Vivo Movement Control Mechanisms of Human Serum Albumin (HSA) and Clinical Application Recombinant HSA Formulas
    1. I-1. Structures of In-Vivo HSA and Drug Bonding Changes During Poor Health
    2. I-2. Drug Delivery Systems Using Mutant and Polymeric HSA
    3. I-3. Kinetic and Pharmacodynamic Evaluation of HSA-Redox Protein Fusions
    4. I-4. Creation of Wound Medicines (Tissue Preservation Liquids, Antibacterials) Using the Pleiotropic Bioactivity of S-Nitrosylated HSA
    5. I-5. Development of Molecular Albumin Absorbent Recirculation System (MARS) Using Toxin Capturing HSA Mutations
  2. II. Elucidation of the Biological Functions and Analysis of the In-Vivo Pathological Characteristics of α1 Acid Glycoprotein (AGP)
    1. II-1. Mapping of Medical Binding Sites in AGP Molecules Using Linear Crystallography
    2. II-2. Elucidation of the Pharmacokinetics and Molecular Mechanisms for Anti-Inflammatory and Immunoregulatory Actions of AGP
    3. II-3. Analysis of the Bioactivity of and Creation of Wound Medicines Using S-Nitrosylated AGP
  3. III. Research Related to the Analysis of Pharmacokinetic Mobilizing Factors in Pathological Conditions and Clinical Applications Thereof
    1. III-1. Elucidation of Molecular Structures Related to Tissue Migration and Redox Properties of Uremic Substances
    2. III-2. Analysis of Expression Variation of Pharmacokinetic Regulatory Proteins During Poor Health
    3. III-3. Elucidation of New Signal Transduction Mechanisms Introduced Through Nitration Reactions During Illness
  4. IV. Pharmacokinetic Analysis of the Characteristics of Artificial Blood Substitutes and Their Applications in Inflammatory Diseases
    1. IV-1. Kinetic and Pharmacodynamic Evaluation of Hemoglobin Endoplasmic Reticulum as an Artificial Oxygen Carrier
    2. IV-2. Kinetic and Pharmacodynamic Evaluation of H12-ADP Liposomes as Artificial Platelets
  5. V. Evaluation of Antioxidant Effects of Drugs and the Basic Construction of New Treatment Strategies Against Oxidation Stress Diseases
    1. V-1. Evaluation of Antioxidant Effects and Elucidation of Mechanisms of Drugs Using Biomarkers
    2. V-2. Quantitative Evaluation of Oxidation Stress During Illness and Evaluation of the Utility of Antioxidant Treatments


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