• Kato, H., Kai, A., Kawabata, T., Sunderhaus, J.D., McAfoos, T.J., Finefield, J.M., Sugimoto, Y., Williams, R.M., Tsukamoto, S.　Enantioselective inhibitory abilities of enantiomers of notoamides against RANKL-induced formation of multinuclear osteoclasts. Bioorg. Med. Chem. Lett. 27, 4975-4978. (2017)
• Aikawa, S., Kano, K., Inoue, A., Wang, J., Saigusa, D., Nagamatsu, K., Hirota, Y., Fujii, T., Tsuchiya, S., Taketomi, Y., Sugimoto, Y., Murakami, M., Arita, M., Kurano, M., Ikeda, H., Yatomi, Y., Chun, J., Aoki, J. Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways. EMBO J. 36, 2146-2160. (2017)
• Yano, A., Takahashi, Y., Moriguchi, H., Inazumi, T., Koga, T., Otaka, A., Sugimoto, Y. An aromatic amino acid within intracellular loop 2 of the prostaglandin EP2 receptor is a prerequisite for selective association and activation of Gαs. Biochim. Biophys. Acta. Mol. Cell Biol. Lipids. 1862, 615-622. (2017)
• Loo, T.M., Kamachi, F., Watanabe, Y., Yoshimoto, S., Kanda, H., Arai, Y., Nakajima-Takagi, Y., Iwama, A., Koga, T., Sugimoto, Y., Ozawa, T., Nakamura, M., Kumagai, M., Watashi, K., Taketo, M.M., Aoki, T., Narumiya, S., Oshima, M., Arita, M., Hara E., Ohtani, N. Gut microbiota promotes obesity-associated liver cancer through PGE2-mediated suppression of antitumor immunity. Cancer Discov. 7,522-538. (2017)

2016

• Yabuki, Y., Koide, T., Miyasaka, N., Wakisaka, N., Masuda, M., Ohkura, M., Nakai, J., Tsuge, K., Tsuchiya, S., Sugimoto, Y., Yoshihara, Y. Olfactory receptor for prostaglandin F2α mediates male fish courtship behavior. Nature Neurosci. 19,897-904. (2016)
• Tsuchiya, H., Hohjoh, H., Fujiwara, Y., Sugimoto, Y., Koshimizu, T. Prostaglandin D2 elicits the reversible neurite retraction in hypothalamic cell line. Biochem. Biophys. Res. Commun. 470, 804-810. (2016)

 

2015

• Inada, M., Takita, M., Yokoyama, S., Watanabe, K., Tominari, T., Matsumoto, C., Hirata, M., Maru, Y., Maruyama, T., Sugimoto, Y., Narumiya, S., Uematsu, S., Akira, S., Murphy, G., Nagase, H., Miyaura, C. Direct melanoma cell contact induces stromal cell autocrine prostaglandin E2-EP4 receptor signaling that drives tumor growth, angiogenesis and metastasis. J. Biol. Chem. 290, 29781-29793. (2015)
• Ikeda, K., Tomimoto, S., Tsuchiya, S., Hamagami, K., Shintani, N., Sugimoto,Y., Ichikawa, A., Kasai, A., Nakazawa, T., Nagayasu, K., Hayata-Takano, A., Baba, A., Hashimoto, H. Comparative gene expression profiles in pancreatic islets associated with agouti yellow mutation and PACAP overexpression in mice. Biochim. Biophys. Rep. 2, 179-183. (2015)
• Higashi, S., Katagi, K., Shintani, N., Ikeda, K., Sugimoto, Y., Tsuchiya, S., Inoue, N., Tanaka, S., Koumoto, M., Kasai, A., Nakazawa, T., Hayata-Takano, A., Hamagami, K., Tomimoto, S., Yoshida, T., Ohkubo, T., Nagayasu, K., Ago, Y., Onaka, Y., Hashimoto, R., Ichikawa, A., Baba, A., Hashimoto, H. p13 overexpression in pancreatic ß-cells ameliorates type 2 diabetes in high-fat-fed mice. Biochem. Biophys. Res. Commun. 461, 612-617. (2015)
• Sugimoto,Y., Inazumi, T., Tsuchiya, S.Roles of prostaglandin receptors in female reproduction. J.Biochem. 157(2), 73-80. (2015)
• Nakamizo,S.,Egawa,G.,Tomura,M.,Sakai,S.,Tsuchiya,s.,Kitoh,A.,Honda,T., Otsuka,A.,Nakajima,S.,Dainichi,T.,Tanizaki,H.,Mitsuyama,M.,Sugimoto,Y.,Kawai,K., Yoshikai,Y., Miyachi,Y.,Kabashima,K.Dermal Vγ4+ γδ T Cells Possess a Migratory Potency to the Draining Lymph Nodes and Modulate CD8+ T-Cell Activity through TNF-α Production. J.Invest Dermatol. 135, 1007-1015(2015)
• Kawahara, K., Hohjoh, H., Inazumi, T., Tsuchiya, S., and Sugimoto, Y. Prostaglandin E2-induced inflammation: relevance of prostaglandin E receptors. Biochim. Biophys, Acta. 1851,414-421(2015)

 

2014

• Natsuaki, Y., Egawa, G., Nakamizo, S., Ono, S., Hanakawa, S., Okada, T., Kusuba, N., Otsuka, A., Kitoh, A., Honda, T., Nakajima, S., Tsuchiya, S., Sugimoto, Y., Ishii, K., Tsutsui, H., Yagita, H., Iwakura, Y., Kubo, M., Ng, L. G., Hashimoto, T., Fuentes, J., Guttman-Yassky, E., Miyachi, Y., Kabashima, K. Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin. Nature Immunol. 15, 1064-1069(2014)
• Hohjoh, H., Inazumi, T., Tsuchiya, S., and Sugimoto, Y. Prostanoid receptors and acute inflammation in skin. Biochimie. 107,78-81(2014)
• Tani, Y., Arita, M., Isobe, Y., Imoto, Y., Segi-Nishida, E., Sugimoto, Y., and Arai, H. Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the pro-resolving mediators and CXCL13 pathway in mice. FASEB J. 28, 4036-4043(2014)
• Kawahara, K., Suenobu, M., Ohtsuka, H., Kuniyasu, A., Sugimoto, Y., Nakagomi, M., Fukasawa, H., Shudo, K., and Nakayama, H. Cooperative therapeutic action of retinoic acid receptor and retinoid X receptor agonists in a mouse model of Alzheimer's disease. J. Alzheimer's Dis. 42(2),587-605(2014)
• Liu, M., Saeki, K., Matsunobu, T., Okuno, T., Koga, T., Sugimoto, Y., Yokoyama, C., Nakamizo, S., Kabashima, K., Narumiya, S., Shimizu, T., and Yokomizo, T. 12-hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor. J. Exp. Med.211, 1063-1078. (2014)
• Morimoto, K., Shirata, N., Taketomi, Y., Tsuchiya, S., Segi-Nishida, E., Inazumi, T., Kabashima, K., Tanaka, S., Murakami, M., Narumiya, S., and Sugimoto, Y. Prostaglandin E₂-EP3 signaling induces inflammatory swelling by mast cell activation. J. Immunol. 192, 1130-1137.(2014)
  熊大プレスリリース（2013.12.19） 熊本日々新聞の紹介記事
• Yokoyama, U., Minamisawa, S., Shioda, A. Jin, M.-H., Ishiwata, R., Masuda, M., Asou, T., Sugimoto, Y., Aoki, H., Nakamura, T., and Ishikawa, Y. Prostaglandin E₂ inhibits elastogenesis in the ductus arteriosus via EP4 signaling. Circulation. 129, 487-496.(2014)
• Nakazawa, S., Sakanaka, M., Furuta, K., Natsuhara, M., Takano, H., Tsuchiya, S., Okuno, Y., Ohtsu, H., Nishibori, M., Thurmond, R.L., Hirasawa, N., Nakayama, K., Ichikawa, A., Sugimoto, Y., and Tanaka, S. Histamine synthesis is required for granule maturation in murine mast cells. Eur. J. Immunol. 44, 204-214. (2014)

 

2013

• Toda, T., Homma, D., Tokuoka, H., Hayakawa, I., Sugimoto, Y., Ichinose, H., and Kawasaki, H. Birth regulates the initiation of sensory map formation through serotonin signaling. Dev. Cell 27, 32-46. (2013)
• Sakaida, M., Sukeno, M., Imoto, Y., Tsuchiya, S., Sugimoto, Y., Okuno, Y., Segi-Nishida, E. Electroconvulsive seizure-induced changes in gene expression in the mouse hypothalamic paraventricular nucleus. J. Psychopharmacol. 27, 1058-1069. (2013)
• Iwasaki, R., Tsuge, K., Morimoto, K., Inazumi, T., Kawahara, O., Kawahara, A., Tsuchiya, S., Sugimoto, Y. Molecular and pharmacological characterization of zebrafish 'contractile' and 'inhibitory' prostanoid receptors. Biochem. Biophys. Res. Commun. 438, 353-358. (2013)
• Tsuge, K., Iwasaki, R., Morimoto, K., Inazumi, T., Kawahara, O., Kawahara, A., Tsuchiya, S., and Sugimoto, Y. Molecular and pharmacological characterization of zebrafish ‘relaxant’ prostanoid receptors. Biochem. Biophys. Res. Commun.436, 685-690. (2013)
• Taketomi, Y., Ueno, N., Kojima, T., Sato, H., Murase, R., Yamamoto, K., Tanaka, S., Sakanaka, M., Nakamura, M., Nishito, Y., Kawana, M., Kambe, N., Ikeda, K., Taguchi, R., Nakamizo, S., Kabashima, K., Gelb, M. H., Arita, M., Yokomizo, T., Nakamura, M., Watanabe, K., Hirai, H., Nakamura, M., Okayama, Y., Ra, C., Aritake, K., Urade, Y., Morimoto, K., Sugimoto, Y., Shimizu, T., Narumiya, S., Hara, S., and Murakami, M. Mast cell maturation is driven via a novel group III phospholipase A₂-prostaglandin D₂-DP1 receptor paracrine axis. Nature Immunol. 14, 554-563. (2013)
• Segi-Nishida, E., Sukeno, M., Imoto, Y., Kira, T., Sakaida, M., Tsuchiya, S., Sugimoto, Y., and Okuno, Y. Electroconvulsive seizures activate anorexigenic signals in the ventromedial nuclei of the hypothalamus. Neuropharmacol. 71, 164-173. (2013)

 

2012

• Tsuchiya S. The Role of MicroRNA-210 in Esophageal Squamous Cell Carcinoma. Yakugaku Zasshi 132, 1069-1073, 2012.
• Nishijima N., Marusawa H., Ueda Y., Takahashi K., Nasu A., Osaki Y., Kou T., Yazumi S., Fujiwara T., Tsuchiya S., Shimizu K., Uemoto S. and Chiba T. Dynamics of Hepatitis B Virus Quasispecies in Association with Nucleos(t)ide Analogue Treatment Determined by Ultra-Deep Sequencing. PLoS One 7, e35052c, 2012.
• Ichikawa T., Sato F., Terasawa K., Tsuchiya S., Toi M., Tsujimoto G. and Shimizu K. Trastuzumab produces therapeutic actions by upregulating miR-26a and miR-30b in breast cancer cells. PLoS One 7, e31422, 2012.
• Morimoto, K., Tsuchiya, S., and Sugimoto, Y. Functions of prostaglandin receptors in contact dermatitis and application to drug discovery. Yakugaku Zasshi. 132, 1217-1223. (2012) [Japanese]
• Yokoyama, U., Ishiwata, R., Jin, M., Kato, Y., Suzuki, O., Jin, H., Ichikawa, Y., Kumagaya, S., Katayama, Y., Fujita, T., Okumura, S., Sato, M., Sugimoto, Y., Aoki, H., Suzuki, S., Masuda, M., Minamisawa, S., and Ishikawa, Y. Inhibition of EP4 signaling attenuates aortic aneurysm formation. PLOS one. 7, e36724. (2012)
• Nakagawa, N., Yuhki, K., Kawabe, J., Fujino, T., Takahata, O., Kabara, M., Abe, K., Kojima, F., Kashiwagi, H., Hasebe, N., Kikuchi, K., Sugimoto, Y., Narumiya, S., and Ushikubi, F. The prostaglandin E2-EP4 system inherent in the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice. Kidney Int. 82, 158-171. (2012)
• Kawahara, K. Suenobu, M., Yoshida, A., Koga, K., Hyodo, A., Ohtsuka, H., Kuniyasu, A., Tamamaki, N., Sugimoto, Y., and Nakayama, H. Intracerebral microinjection of interleukin-4/interleukin-13 reduces beta-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young APP23 mice.(2012) Neuroscience. 207, 243-260.
• Hoshino T, Namba T, Takehara M, Murao N, Matsushima T, Sugimoto Y, Narumiya S, Suzuki T, Mizushima T. Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP(4) receptor. (2012) J. Neurochem. 120, 795-805.
• Takano, H., Furuta, K., Yamashita, K., Sakanaka, M., Itano, N., Gohda, E., Nakayama, K., Kimata, K., Sugimoto, Y., Ichikawa, A., and Tanaka, S. Restriction of mast cell proliferation through hyaluronan synthesis by co-cultured fibroblasts. (2012) Biol. Pharm. Bull. 35, 408-412.

 

2011

• Doi, M., Ishida, A., Miyake, A., Sato, M., Komatsu, R., Yamazaki, F., Kimura, I., Tsuchiya, S., Kori, H., Seo, K., Yamaguchi, Y., Matsuo, M., Fustin, J-M., Tanaka, R., Santo, Y., Yamada, H., Takahashi, Y., Araki, M., Nakao, K., Aizawa, S., Kobayashi, M., Obrietan, K., Tsujimoto, G., and Okamura, H. Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus. (2011) Nat. Commun. 2, 327.
• Tsuchiya, S., Fujiwara, T., Sato, F., Shimada, Y., Tanaka, E., Sakai, Y., Shimizu, K., and Tsujimoto, G. MicroRNA-210 Regulates Cancer Cell Proliferation through Targeting Fibroblast Growth Factor Receptor-Like 1 (FGFRL1). (2011) J. Biol. Chem. 286, 420-428.
• Sato, F., Tsuchiya, S., Meltzer, S., and Shimizu, K. MicroRNAs and Epigenetics. FEBS J. (2011) 278, 1598-1609.
• Imanaka, Y., Tsuchiya, S., Sato, F., Shimada, Y., Shimizu, K., and Tsujimoto, G. MicroRNA-141 Confers Resistance to Cisplatin-induced Apoptosis by Targeting YAP1 in Human Esophageal Squamous Cell Carcinoma. J. Hum. Genet. (2011) 56, 270-276.
• Sato, F., Hatano, E., Kitamura, K., Myomoto, A., Fujiwara, T., Takizawa, S., Tsuchiya, S., Tsujimoto, G., Uemoto, S., and Shimizu, K. MicroRNA Profile Predicts Recurrence After Resection in Patients with Hepatocellular Carcinoma within the Milan Criteria. PLoS One (2011) 6, e16435.
• Inazumi, T., Shirata, N., Morimoto, K., Takano, H., Segi-Nishida, E., and Sugimoto, Y. Prostaglandin E2-EP4 signaling suppresses adipocyte differentiation in mouse embryonic fibroblasts via an autocrine mechanism. (2011) J. Lipid Res. 52, 1500-1508.

 

2010

• Tamba, S., Yodoi, R., Morimoto, K., Inazumi, T., Sukeno, M., Segi-Nishida, M., Okuno, Y., Tsujimoto, G., Narumiya, S., and Sugimoto, Y. Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling.(2010) Biochimie. 92, 665-675.
• Ichikawa, A., Sugimoto, Y., and Tanaka, S. Molecular biology of histidine decarboxylase and prostaglandin receptors.(2010) Proc. Jpn. Acad., Ser. B. 86, 848-866.
• Kusaka, M., Katoh-Fukui, y., Ogawa, H., Miyabayashi, K., Baba, T., Shima, Y., Sugiyama, N., Sugimoto, Y., Okuno, Y., Kodama, R., Izuka-Kogo, A., Senda, T., Sasaoka, T., Kitamura, K., Aizawa, S., and Morohashi, K. Abnormal epithelial cell polarity and ectopie epidermal growth factor receptor(EGFR) expression induced in Emx2 KO embryonic gonads.(2010) Endocrinology, 151, 5893-5904.
• Katoh, H., Hosono, K., Ito, Y., Suzuki, T., Ogawa, Y., Kubo, H., Kamata, H., Mishima, T., Tamaki, H., Sakagami, H., Sugimoto, Y., Narumiya, S., Watanabe, M., and Majima, M. COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems.(2010) Am. J. Pathol. 176, 1469-1483.
• Mizuguchi, S., Ohno, T., Hattori, Y., Ae, T., Minamino, T., Satoh, T., Arai, K., Saeki, T., Hayashi, I., Sugimoto, Y., Narumiya, S., Saigenji, K., and Majima, M. Role of Prostaglandin E2-EP1 Receptor Signaling in Regulation of Gastric Motot Activity and Emptying.(2010) Am. J. Physiol. Gastrointest. Liver Physiol., 299,G1078-G1086.
• Ueno, T., Suzuki, T., Oikawa, A., Hosono, K., Kosaka, Y., Amano, H., Kitasato, H., Toda, M., Hayashi, I., Kato, T., Ito, Y., Sugimoto, Y., Narumiya, S., Okamoto, H., and Majima, M. Recruited bone marrow cells expressing the EP3 prostaglandin E receptor subtype enhance angiogenesis during chronic inflammation. (2010) Biomed. Pharmacother. 64, 93-100.
• Kubo, H., Hosono, K., Suzuki, T., Ogawa, Y., Kato, H., Kamata, H., Ito, Y., Amano, H., Kato, T., Sakagami, H., Hayashi, I., Sugimoto, Y., Narumiya, S., Watanabe, M., and Majima, M. Host prostaglandin EP3 receptor signaling relevant to tumor-associated lymphangiogenesis.(2010) Biomed. Pharmacother. 64, 101-106.

 

2009

• Tsuchiya, S., Oku, M., Imanaka, Y., Kunimoto, R., Okuno, Y., Terasawa, K., Sato, F., Tsujimoto, G., and Shimizu, K. MicroRNA-338-3p and microRNA-451 contribute to the formation of basolateral polarity in epithelial cells. Nucleic Acids Res. (2009) 37, 3821-3827.
• Sato, F., Tsuchiya, S., Terasawa, K., and Tsujimoto, G. Intra-platform Repeatability and Inter-platform Comparability of MicroRNA Microarray Technology. PLoS One (2009) 4, e5540.
• Amano, H., Ito, Y., Suzuki, T., Kato, S., Matsui, Y., Ogawa, F., Murata, T., Sugimoto, Y., Senior, R., Kitasato, H., Hayashi, I., Satoh, Y., Narumiya, S., and Majima, M. Roles of a prostaglandin E-type receptor, EP3, in upregulation of matrix metalloproteinas e-9 and vascular endothelial growth factor during enhancement of tumor metastasis. (2009) Cancer. Sci.  100, 2318-2324.
• Kuge, Y., Obokata, N., Kimura, H., Katada, Y., Temma, T., Sugimoto, Y., Aita, K., Seki, K., Tamaki, N., and Saji, H. Synthesis and evaluation of a radioiodinated Lumiracoxib derivative for the imaging of cyclooxygenase-2 expression. (2009) Nuc. Med. Biol. 36, 869-876.
• Yamaoka, K., Yano, A., Kuroiwa, K., Morimoto, K., Inazumi, T., Hatae, N., Tabata, H., Segi-Nishida, E., Tanaka, S., Ichikawa, A., and Sugimoto, Y. Prostaglandin EP3 receptor superactivates adenylyl cyclase via the Gq/PLC/Ca2+ pathway in a lipid raft-dependent manner. (2009) Biochem. Biophys. Res. Commun. 389, 678-682.
• Suzuki-Yamamoto, T., Toida, K., Sugimoto, Y., and Ishimura, K. Colocalization of prostaglandin F receptor FP and prostglandin F synthase-I in the spinal cord. (2009) J. Lipid. Res. 50, 1996-2003.
• Yao, C., Sakata, D., Esaki, Y., Li, Y., Matsuoka, T., Kuroiwa, K., Sugimoto, Y., and Narumiya, S. Prostaglandin E2-EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion. (2009) Nat. Med. 15, 633-640.
• Yodoi, R., Tamba, S., Morimoto, K., Segi-Nishida, E., Nishihara, M., Ichikawa, A., Narumiya, S., and Sugimoto, Y. RhoA/Rho kinase signaling in the cumulus mediates extracellular matrix assembly. (2009) Endocrinology. 150, 3345-3352.
• Kunori, S., Matsumura, S., Mabuchi, T., Tatsumi, S., Sugimoto, Y., Minami, T., and Ito, S. Involvement of prostaglandin F2a receptor in ATP-induced mechanical allodynia. (2009 ) Neuroscience. 163, 362-371.
• Hoshino, T., Namba, T., Takehara, M., Nakaya, T., Sugimoto, Y., Araki, W., Narumiya, S., Suzuki, T., and Mizushima, T. Prostaglandin E2 stimulates the production of amyloid beta peptides through internalization of the EP4 receptor. (2009) J. Biol. Chem. 284, 18493-18502.
• Ogawa, Y., Suzuki, T., Oikawa, A., Hosono, K., Kubo, H., Amano, H., Kitasato, H., Hayashi, I., Kato, T., Sugimoto, Y., Narumiya, S., Watanabe, M., and Majima, M. Bone marrow-derived EP3-expressing stromal cells enhance tumor-associated angiogenesis and tumor growth. (2009) Biochem. Biophys. Res. Commun. 382, 720-725.
• Hori, R., Nakagawa, T., Sugimoto, Y., Sakamoto, T., Yamamoto, N., Hamaguchi, K., Ito, J. Prostaglandin E receptor subtype EP4 agonist protects cochleae against noise-induced trauma. (2009) Neuroscience. 160, 813-819.
• Takano, H., Nakazawa, S., Shirata, N., Tamba, S., Furuta, K., Tsuchiya, S., Morimoto, K, Itano, N., Irie, A., Ichikawa, A., Kimata, K., Nakayama, K., Sugimoto, Y., and Tanaka, S. Involvement of CD44 in mast cell proliferation during terminal differentiation. (2009) Lab. Invest. 89, 446-455.
• Tsuchiya, S., Tachida, Y., Segi-Nishida, E., Okuno, Y., Tamba, S., Tsujimoto, G., Tanaka, S., and Sugimoto, Y. Characterization of gene expression profiles fordifferent types of mast cells pooled from mouse stomach 　subregions by an RNA amplification method. (2009) BMC. Genomics. 10, 35.

 

 

2008

• Ruike, Y., Ichimura, A., Tsuchiya, S., Shimizu, K., Kunimoto, R., Okuno, Y., and Tsujimoto, G. Global correlation analysis for micro-RNA and mRNA expression profiles in human cell lines. J. Hum. Genet. (2008) 53, 515-523.
• Sakanaka, M., Tanaka, S.,Sugimoto, Y., and Ichikawa, A. Essential role of EP3 subtype in prostaglandin E2-induced adhesion of mouse cultured and peritoneal mast cells to the Arg-Gly-Asp-enriched matrix. (2008) Am.J.Physiol.Cell. Physiol.295, C1427-C1433.
• Tamba, S., Yodoi, R., Segi-Nishida, E., Ichikawa, A., Narumiya, S., and Sugimoto, Y. Timely interaction between prostaglandin and chemokine signaling is a prerequisite for successful fertilization. (2008) Proc. Natl. Acad. Sci. USA. 105, 14539-14544.
• Yano, Y., Yano, A., Oishi, S., Fujii, N., Sugimoto, Y., and Matsuzaki, K. Coiled-coil tag-robe system for quick labeling of membrane receptors in living cells.(2008) ACS .Chem. Biol. 3, 341-345.
• Yano, Y., Shimbo, T., Sugimoto, Y., and Matsuzaki, K. Intracellular third loop-C-terminal tail interaction in prostaglandin EP3β receptor. (2008) Biochem. Biophys. Res. Commun. 371, 846-849.
• Takano, H., Nakazawa, S., Okuno, Y., Shirata, N., Tsuchiya, S., Kainoh, T., Takamatsu, S., Furuta, K., Taketomi, Y., Naito, Y., Takematsu, H., Kozutsumi, Y., Tsujimoto, G., Murakami, M., Kudo, I., Ichikawa, A., Nakayama, K., Sugimoto, Y., and Tanaka, A. Establishment of the culture model system that reflects the process of terminal differentiation of connective tissue-type mast cells. (2008) FEBS. Lett 582, 1444-1450.
• Tsuchiya, H., Oka, T., Nakamura, K., Ichikawa, A., Saper, C. B., and Sugimoto, Y. Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 receptors. (2008 ) J. Biol. Chem. 283, 11064-11071.
• Yuhki, K.I., Ushikubi, F., Naraba, H., Ueno, A., Kato, H., Kojima, F., Narumiya, S., Sugimoto, Y., Matsushita, M., and Oh-Ishi, S. Prostaglandin I2 plays a key role in zymosan-induced mouse pleurisy.(2008) J. Pharmacol. Exp. Ther. 325, 601-609.
• Esumi, S., Wu, S-X., Yanagawa, Y., Obata, K., Sugimoto, Y., and Tamamaki, N. Method for single-cell microarray analysis and application to gene-expression profiling of GABAergic neuron progenitors. (2008) Neurosci. Res. 60, 439-451.
• Yellon, S. M., Ebner, C. A., and Sugimoto, Y. Parturition and recruitment of macrophages in cervix of mice lacking the prostaglandin F receptor. (2008) Biol. Reprod. 78, 438-444.
• Kawamata, M., Yoshida, M. Sugimoto, Y., Kimura, T., Tonomura, Y., Takayanagi, Y., Yanagisawa, T., and Nishimori, K. Infusion of oxytocin induces successful delivery in prostanoid FP-receptor-deficient mice. (2008) Mol. Cell. Endocrinol. 283, 32-37.

 

2007

• Ikeda, A., Miyazaki, T., Kakizawa, S., Okuno, Y., Tsuchiya, S., Myomoto, A., Saito, S., Yamamoto, S., Yamazaki, T., Iino, M., Tsujimoto, G., Watanabe, M., and Takeshima, H. Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins. Biochem. Biophys. Res. Commun., (2007) 363, 835-839.
• Hoshino, T., Nakaya, T., Homan, T., Tanaka, K., Sugimoto, Y., Araki, W., Narita, M., Narumiya, S., Suzuki, T., and Mizushima, T. Involvement of prostaglandin E2 in production of amyloid-peptides both in vitro and in vivo. (2007) J. Biol. Chem. 282, 32676-32688.
• Suzuki-Yamamoto, T., Sugimoto, Y, Ichikawa, A., and Ishimura, K.Co-localization of prostaglandin F synthase, cyclooxygenase-1 and prostaglandin F receptor in mouse Leydig cells. (2007) Histochem. Cell. Biol. 128(4),317-322.
• Taketomi, Y., Sunaga, K,. Tanaka, S., Nakamura, M., Arata, S., Okuda, T., Moon, T.C., Chang, H.W., Sugimoto, Y., Kokame, K., Miyata, T., Murakami, M., and Kudo, I.Impaired mast cell maturation and degranulation and attenuated allergic responses in ndrg1-deficient mice. (2007) J. Immunol. 178, 7042-7053.
• Furuta, K., Nakayama, K., Sugimoto, Y., Ichikawa, A., and Tanaka, S.Activation of histidine decarboxylase through post-translational cleavage by caspase-9 in a mouse mastocytoma P-815. (2007) J. Biol. Chem. 282 (18), 13438-13446.
• Sugimoto, Y., and Narumiya, S.Prostaglandin E receptors. (2007) J. Biol. Chem. 282 (16), 11613-11617.
• Kawamata, M., Tonomura, Y., Kimura, T., Sugimoto, Y., Yanagisawa, T., and Nishimori, K.Oxytocin-induced phasic and tonic contractions are modulated by the contractile machinery rather than the quantity of oxytocin receptor. (2007) Am. J. Physiol. Endocrinol. Metab. 292 (4), E992-E999.

 

 

2006

• Tsuchiya, S., Okuno, Y., and Tsujimoto, G. MicroRNA: biogenetic and functional mechanisms and involvements in cell differentiation and cancer. J. Pharmacol. Sci. (2006) 101, 267-270.
• Yokoyama, U., Minamisawa, S., Hong, Q., Ghatak, S., Akaike, T., Segi-Nishida, E., Iwasaki, S., Iwamoto, M., Misra, S., Tamura, K., Hori, H., Yokota, S., Toole, B.P., Sugimoto, Y., and Ishikawa, Y.Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus. (2006) J. Clin. Invest. 116, 3026-3034.
• Osada, S., Naganawa, A., Misonou, M., Tsuchiya. S., Tamba, S., Okuno, Y., Nishikawa, J., Satoh, K., Imagawa, I, Tsujimoto, G., Sugimoto, Y., and Nishihara, T.Altered gene expression of transcriptional regulatory factors in tumor marker-positive cells during chemically induced hepatocarcinogenesis. (2006) Toxicol. Lett. 167, 106-113.
• Trivedi, D.B., Sugimoto, Y., and Loftin, C.D.Attenuated cyclooxygenase-2 expression contributes to patent ductus arteriosus in preterm mice. (2006) Pediatr. Res. 60, 669-674.
• Shioji, M., Fukuda, H., Kanzaki, T., Wasada, K., Kanagawa, T., Shimoya, K., Mu, J., Sugimoto, Y., Murata, Y.Reduction of aquaporin-8 on fetal membranes under oligohydramnios in mice lacking prostaglandin F2 alpha receptor. (2006) J. Obstet. Gynaecol. Res. 32, 373-378.
• Kim, H., Arakawa, H., Hatae, N., Sugimoto, Y., Matsumoto, O., Osada, T., Ichikawa, A., and Ikai, A. Quantification of the number of EP3 receptors on a living CHO cell surface by the AFM.(2006) Ultramicroscopy. 106, 652-662.

 

2005

• Shoji, Y., Takahashi, M., Takasuka, N., Niho, N., Kitamura, T., Sato, H., Maruyama, T., Sugimoto, Y., Narumiya, S., Sugimura, T., and Wakabayashi, K.Prostaglandin E receptor EP3 deficiency modifies tumor outcome in mouse two-stage skin carcinogenesis. (2005) Carcinogenesis. 26, 2116-2122.
• Liu, Y., Furuta, K., Teshima, R., Shirata, N., Sugimoto, Y., Ichikawa, A., and Tanaka, S.Critical role of PKC[beta]II in activation of mast cells by monomeric IgE. (2005) J. Biol. Chem. 280, 38976-38981.
• Sugimoto, Y., Fukada, Y., Mori, D., Tanaka, S., Yamane, H., Okuno, Y., Deai, K., Tsuchiya, S., Tsujimoto, G., and Ichikawa, A. Prostaglandin E2 stimulates granulocyte-colony stimulating factor production via the prostanoid EP2 receptor in mouse peritoneal neutrophils. (2005) J. Immunol. 175, 2606-2612.
• Takasaki, I., Nojima, H., Shiraki, K., Sugimoto, Y., Ichikawa, A., Ushikubi, F., Narumiya, S., and Kuraishi, Y. Involvement of cyclooxygenase-2 and EP(3) prostaglandin receptor in acute herpetic but not postherpetic pain in mice.(2005) Neuropharmacology. 49, 283-292.
• Kunikata, T., Yamane, H., Segi, E., Matsuoka, T., Sugimoto, Y., Tanaka, S., Tanaka, H., Nagai, H., Ichikawa, A., and Narumiya, S. Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3. (2005) Nature Immunol. 6, 524-531
• Moriyama, T., Higashi, T., Togashi, K., Iida, T., Segi, E., Sugimoto, Y., Tominaga, T., Narumiya, S., and Tominaga, M. Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins. (2005) Molecular Pain.1, 3
• Foyouzi, N., Cai, Z., Sugimoto, Y., and Stocco, C. Changes in the expression of steroidgenic and antioxidant genes in the mouse corpus luteum during luteolysis. (2005) Biol. Reprod.72,1134-1141
• Tanaka, S., Mikura, S., Hashimoto, E., Sugimoto, Y., and Ichikawa, A. Ca2+ influx-mediated histamine synthesis and IL-6 release in mast cells activated by monomeric IgE.(2005) Eur. J. Immunol.35, 460-468
• Hirasawa, A., Tsumaya, K., Awaji, T., Katsuma, S., Adachi, T., Yamada, M., Sugimoto, Y., Miyazaki, S., and Tsujimoto, G. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120.(2005) Nature Med.11, 90-94

 

2004

• Tsuboi, H., Sugimoto, Y., Kainoh, T, and Ichikawa, A. Prostanoid EP4 receptor is involved in suppression of 3T3-L1 adipocyte differentiation. (2004) Biochem. Biophys.322, 1066-1072
• Sugimoto, Y., Tsuboi, H., Okuno, Y., Tamba, S., Tsuchiya, S., Tsujimoto, G., and Ichikawa, A. Microarray evaluation of EP4 receptor mediated prostaglandin E2 suppression of 3T3-L1 adipocyte differentiation. (2004) Biochem. Biophys. Res. Commun.322, 911-917
• Sugimoto, Y., Nakato, T., Kita, A., Takahashi, Y., Hatae, N., Tabata, H., Tanaka, S., and Ichikawa, A. A cluster of aromatic amino acids in the i2 loop plays a key role for Gs coupling in prostaglandin EP2 and EP3 receptors. (2004) J. Biol. Chem.279, 11016-11026
• Tanaka, S., Deai, K., Konomi, A., Takahashi, K., Yamane, H., Sugimoto, Y., and Ichikawa, A. Expression of L-histidine decarboxylase in granules of elicited mouse polymorphonuclear leukocytes. (2004) Eur. J. Immunol.34, 1472-1482
• Shoji, Y., Takahashi, M., Kitamura, T., Watanabe, K., Kawamori, T., Maruyama, T., Sugimoto, Y., Negishi, M., Narumiya, S., Sugimura, T., and Wakabayashi, K. Down-regulation of prostaglandin E receptor subtype EP3 during colon cancer development. (2004) Gut.53, 1151-1158

 

 

2003

• Sugimoto, Y., Narumiya, S., and Ichikawa, A. Insight into prostanoid functions: lessons from receptor-knockout mice.(2003) in The Eicosanoids.Chapter 18. pp. 219-2525. (Ed. Peter Curtis-Prior.) John Wiley & Sons, Ltd. West Sussex, U.K.
• Sugimoto, Y., Nakato, T., Kita, A., Hatae, N., Tabata, H., Tanaka, S., and Ichikawa, A. Functional domains essential for Gs activity in prostaglandin EP2 and EP3 receptors. (2003) Life Sci.74, 135-141
• Tsuchiya, S., Tanaka, S., Sugimoto, Y., Katsuyama, M., Ikegami, R., and Ichikawa, A. Identification and characterization of a novel progesterone receptor-binding element in the mouse prostaglandin E receptor subtype EP2 gene. (2003) Genes Cells.8, 747-758
• Oka, T., Oka, K., Kobayashi, T., Sugimoto, Y., Ichikawa, A., Ushikubi, F., Narumiya, S., and Saper, C.B. Characteristics of thermoregulatory and febrile responses in mice deficient in prostaglandin EP1 and EP3 receptors. (2003) J. Physiol.551, 945-954
• Minami, T., Matsumura, S., Mabuchi, T., Kobayashi, T., Sugimoto, Y., Ushikubi, F., Ichikawa, A., Narumiya, S., and Ito, S. Functional evidence for interaction between prostaglandin EP3 and kappa-opioid receptor pathways in tactile pain induced by human immunodeficiency virus type-1 (HIV-1) glycoprotein gp120. (2003) Neuropharmacology.45, 96-105
• Shoda, J., Ueda, T., Kawamoto, T., Todoroki, T., Asano, T., Sugimoto, Y., Ichikawa, A., Maruyama, T., Nimura, Y., and Tanaka, N. Prostaglandin E receptors in bile ducts of hepatolithiasis patients and the pathobiological Significance for cholangitis. (2003) Clin. Gastroenterol. Hepatol.1, 285-296
• Hatae, N., Kita, A., Tanaka, S., Sugimoto, Y., and Ichikawa, A. Induction of adherent activity in mastocytoma P-815 cells by the cooperation of two prostaglandin E2 receptor subtypes, EP3 and EP4.(2003) J. Biol. Chem.278, 17977-17981
• Saito, O., Guan, Y., Qi, Z., Davis, L.S., Komhoff, M., Sugimoto, Y., Narumiya, S., Breyer, R.M., and Breyer, M.D. Expression of the Prostaglandin F Receptor (FP) gene along the mouse genitourinary tract.(2003) Am. J. Physiol. Renal Physiol.286, F1164-F1170
• Tsuboi, K., Iwane, A., Nakazawa, S., Sugimoto, Y., and Ichikawa, A. Role of prostaglandin H2 synthase-2 in murine parturition: study on ovariectomy-induced parturition in prostaglandin F receptor-deficient mice. (2003) Biol. Reprod.69, 195-201
• Mu, J., Kanzaki, T., Si, X., Tomimatsu, T., Fukuda, H., Shioji, M., Murata, Y., Sugimoto, Y., and Ichikawa, A. Apoptosis and related proteins in placenta of intrauterine fetal death in prostaglandin F receptor-deficient mice. (2003) Biol. Reprod.68, 1968-1974
• Segi, E., Haraguchi, K., Sugimoto, Y., Tsuji, M., Tsunekawa, H., Tamba, S., Tsuboi, K., Tanaka, S., and Ichikawa, A. Expression of messenger RNA for prostaglandin E receptor subtypes EP4/EP2 and cyclooxygenase isozymes in mouse periovulatory follicles and oviducts during superovulation. (2003) Biol. Reprod.68, 804-811
• Amano, H., Hayashi, I., Endo, H., Kitasato, H., Yamashina, S., Maruyama, T., Kobayashi, M., Satoh, K., Narita, M., Sugimoto, Y., Murata, T., Yoshimura, H., Narumiya, S., and Majima, M. Host prostaglandin E2-EP3 signaling regulates tumor-associated angiogenesis and tumor growth. (2003) J. Exp. Med.197, 221-232

 

2002

• Tsuboi, K., Sugimoto, Y., and Ichikawa, A. Prostanoid receptor subtypes. (2002) Prostaglandins Other Lipid Mediat.68-69, 535-556
• Tabata, H., Tanaka, S., Sugimoto, Y., Kanki, H., Kaneko, S., and Ichikawa, A. Possible coupling of prostaglandin E receptor EP1 to TRP5 expressed in X. laevis oocytes. (2002) Biochem. Biophys. Res. Commun.298, 398-402
• Tsuboi, K., Segi, E., Sugimoto, Y., and Ichikawa, A*. Role of prostanoids on female reproduction revealed by receptor-deficient mice. (2002) Recent Res. Devel. Endocrinol.3, 119-126
• Hatae, N., Sugimoto, Y., and Ichikawa, A. Prostaglandin receptors: advances in the study of EP3 receptor signaling. (2002) J. Biochem. (Tokyo).131, 781-784
• Asano, T., Shoda, J., Ueda, T., Kawamoto, T., Todoroki, T., Shimonishi, M., Tanabe, T., Sugimoto, Y., Ichikawa, A., Mutoh, M., Tanaka, N., and Miwa, M. Expressions of cyclooxygenase-2 and prostaglandin e-receptors in carcinoma of the gallbladder: crucial role of arachidonate metabolism in tumor growth and progression. (2002) Clin. Cancer Res.8, 1157-1167
• Tsuboi, K., Sugimoto, Y., and Ichikawa, A*. Prostaglandin E2 and F2a in mouse reproduction. (2002) International Congress Series.1233, 397-404
• Safina, F., Tanaka, S., Inagaki, M., Tsuboi, K., Sugimoto, Y., and Ichikawa, A. Expression of L-histidine decarboxylase in mouse male germ cells. (2002) J. Biol. Chem.277, 14211-14215.
• Yoshida, K., Oida, H., Kobayashi, T., Maruyama, T., Tanaka, M., Katayama, T., Yamaguchi, K., Segi, E., Tsuboyama, T., Matsushita, M., Ito, K,. Ito, Y., Sugimoto, Y., Ushikubi, F., Ohuchida, S., Kondo, K., Nakamura, T., and Narumiya, S. Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation. (2002) Proc. Natl. Acad. Sci. USA.99, 4580-4585
• Kabashima, K., Saji, T., Murata, T., Nagamachi, M., Matsuoka, T., Segi, E., Tsuboi, K., Sugimoto, Y., Kobayashi, T., Miyachi, Y., Ichikawa, A., and Narumiya, S. The prostaglandin E receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut.(2002) J. Clin. Invest .109, 883-893
• Mu, J., Kanzaki, T., Tomimatsu, T., Fukuda, H., Wasada, K., Fujii, E., Endoh, M., Kozuki, M., Murata, Y., Sugimoto, Y., and Ichikawa, A. Expression of apoptosis in placentae from mice lacking the prostaglandin F receptor.(2002) Placenta .23, 215-223
• Mu, J., Kanzaki, T., Tomimatsu, T., Fukuda, H., Wasada, K., Fujii, E., Endoh, E., Kozuki, M., Murata, Y., Sugimoto, Y., and Ichikawa, A. Apoptosis and related proteins during parturition in prostaglandin F receptor-deficient mice.(2002) Biochem. Biophys. Res. Commun .292, 675-681
• Fennekohl, A., Sugimoto, Y., Segi, E., Maruyama, T., Ichikawa, A., and Puschel, G. P. Contribution of the two Gs-coupled PGE(2)-receptors EP2-receptor and EP4-receptor to the inhibition by PGE(2) of the LPS-induced TNFalpha-formation in Kupffer cells from EP2-or EP4-receptor-deficient mice. Pivotal role for the EP4-receptor in wild type Kupffer cells.(2002) J. Hepatol.36, 328-334
• Mutoh, M., Watanabe, K., Kitamura, T., Shoji, Y., Takahashi, M., Kawamori, T., Tani, K., Kobayashi, M., Maruyama, T., Kobayashi, K., Ohuchida, S., Sugimoto, Y., Narumiya, S., Sugimura, T., and Wakabayashi, K. Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.(2002) Cancer Res.62, 28-32
• Torii, E., Segi, E., Sugimoto, Y., Takahashi, K., Kabashima, K., Ikai, K., and Ichikawa, A. Expression of prostaglandin E(2) receptor subtypes in mouse hair follicles.(2002) Biochem. Biophys. Res. Commun.290, 696-700
• Hatae, N., Yamaoka, K., Sugimoto, Y., Negishi, M., and Ichikawa, A. Augmentation of receptor-mediated adenylyl cyclase activity by Gi-coupled prostaglandin receptor subtype EP3 in a Gbetagamma subunit-independent manner.(2002) Biochem. Biophys. Res. Commun.290, 162-168

 

2001

• Ma, H., Hara, A., Xiao, C.Y., Okada, Y., Takahata, O., Nakaya, K., Sugimoto, Y., Ichikawa, A., Narumiya, S., and Ushikubi, F. Increased bleeding tendency and decreased susceptibility to thromboembolism in mice lacking the prostaglandin E receptor subtype EP3.(2001) Circulation.104, 1176-1180
• Sonoshita, M., Takaku, K., Sasaki, N., Sugimoto, Y., Ushikubi, F., Narumiya, S., Oshima, M., and Taketo, M.M. Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apcd716 knockout mice. (2001) Nature Med.7, 1048-1051
• Ueno, A., Matsumoto, H., Naraba, H., Ikeda, Y., Ushikubi, F., Matsuoka, T., Narumiya, S., Sugimoto, Y., Ichikawa, A., and Oh-ishi, S. Major roles of prostanoid receptors IP and EP3 in endotoxin-induced enhancement of pain perception. (2001) Biochem. Pharmacol.62, 157-160
• Minami, T., Nakano, H., Kobayashi, T., Sugimoto, Y., Ushikubi, F., Ichikawa, A., Narumiya, S., and Ito, S. Characterization of EP receptor subtypes responsible for prostaglandin E2-induced pain responses by use of EP1 and EP3 receptor knockout mice. (2001) Br. J. Pharmacol.133, 438-444
• Ikegami, R., Sugimoto, Y., Segi, E., Katsuyama, M., Karahashi, H., Amano, F., Maruyama, T., Yamane, H., Tsuchiya, S. and Ichikawa, A. The expression of prostaglandin E receptors EP2 and EP4 and their different regulation by lipopolysaccharide in C3H/HeN peritoneal macrophages. (2001) J. Immunol.166, 4689-4696
• Shinomiya, S., Naraba, H., Ueno, A., Utsunomiya, I., Maruyama, T., Ohuchida, S., Ushikubi, F., Yuki, K., Narumiya, S., Sugimoto, Y., Ichikawa, A., and Oh-ishi, S. Regulation of TNFalpha and interleukin-10 production by prostaglandins I(2) and E(2): studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists. (2001) Biochem. Pharmacol.61, 1153-1160

 

 

2000

• Yamane, H., Sugimoto, Y., Tanaka, S., and Ichikawa, A. Prostaglandin E2 receptors, EP2 and EP4, differentially modulate TNF-α and IL-6 production induced by lipopolysaccharide in mouse peritoneal neutrophils. (2000) Biochem. Biophys. Res. Commun.278, 224-228
• Stocco, C.O., Zhong, L., Sugimoto, Y., Ichikawa, A., Lau, L. F., and Gibori, G. Prostaglandin F2a induced expression of 20a-hydroxysteroid dehydrogenase involves the transcription factor Nur77. (2000) J. Biol. Chem.275, 37202-37211
• Sakuma Y, Tanaka K, Suda M, Komatsu Y, Yasoda A, Miura M, Ozasa A, Narumiya S, Sugimoto, Y, Ichikawa A, Ushikubi F, and Nakao K. Impaired bone resorption by lipopolysaccharide in vivo in mice deficient in the prostaglandin E receptor EP4 subtype. (2000) Infect. Immun.68, 6819-6825
• Ushikubi, F., Sugimoto, Y., Ichikawa, A., and Narumiya, S. Roles of prostanoids revealed from studies using mice lacking specific prostanoid receptors. (2000) Jpn. J. Pharmacol.83, 279-285
• Sugimoto, Y., Narumiya, S., and Ichikawa, A. Distribution and function of prostanoid receptors: studies from knockout mice. (2000) Prog. Lipid Res.39, 289-314
• Miyaura, C., Inada, M., Suzawa, T., Sugimoto, Y., Ushikubi, F., Ichikawa, A., Narumiya, S., and Suda, T. Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice. (2000) J. Biol. Chem.275, 19819-19823
• Sakuma, Y., Tanaka, K., Suda, M., Yasoda, A., Natsui, K., Tanaka, I., Ushikubi, F., Narumiya, S., Segi, E., Sugimoto, Y., Ichikawa, A., and Nakao, K. Crucial involvement of the EP4 subtype of prostaglandin E receptor in osteoclast formation by proinflammatory cytokines and lipopolysaccharide. (2000) J. Bone Miner. Res.15, 218-227
• Matsuoka, T., Hirata, M., Tanaka, H., Takahashi, Y., Murata, T., Kabashima, K., Sugimoto, Y., Kobayashi, T., Ushikubi, F., Aze, Y., Eguchi, N., Urade, Y., Yoshida, N., Kimura, K., Mizoguchi, A., Honda, Y., Nagai, H., and Narumiya, S. Prostaglandin D2 as a mediator of allergic asthma.(2000) Science.287, 2013-2017
• Suzawa, T., Miyaura, C., Inada, M., Maruyama, T., Sugimoto, Y., Ushikubi, F., Ichikawa, A., Narumiya, S., and Suda, T. The role of prostaglandin E receptor subtypes (EP1, EP2, EP3 and EP4) in bone resorption: an analysis using specific agonists for the respective EPs.(2000) Endocrinology.141, 1554-1559
• Croy, B. A., Chantakru, S., Narumiya, S., Ichikawa, A., and Sugimoto, Y. Prolonged gestation does not extend survival of uterine Natural Killer lymphocytes in mice deleted in the receptor for Prostaglandin F2 alpha.(2000) J. Reprod. Immunol.46, 125-129
• Tsuboi, T., Sugimoto, Y., Iwane, A., Yamamoto, K., Yamamoto, S., and Ichikawa, A. Uterine expression of prostaglandin H2 synthase in late pregnancy and during parturition in prostaglandin F receptor-deficient mice.(2000) Endocrinology.141, 315-324

 

1999

• Takeuchi, K., Ukawa, H., Kato, S., Furukawa, O., Araki, H., Sugimoto, Y., Ichikawa, A., Ushikubi, F., and Narumiya, S. Impaired duodenal bicarbonate secretion and mucosal integrity in mice lacking prostaglandin E-receptor subtype EP(3).(1999) Gastroenterology.117, 1128-1135
• Wang, J., Yamamoto, K., Sugimoto, Y., Ichikawa, A., and Yamamoto, S. Induction of prostaglandin I2 receptor by tumor necrosis factor alpha in osteoblastic MC3T3-E1 cells.(1999) Biochim. Biophys. Acta.1441, 69-76
• Narumiya, S., Sugimoto, Y., and Ushikubi, F. Prostanoid receptors; structures, properties and functions.(1999) Physiol. Rev.79, 1193-1226
• Hizaki, H., Segi, E., Sugimoto, Y., Hirose, M., Saji, T., Ushikubi, F., Matsuoka, T., Noda, Y., Tanaka, T., Yoshida, N., Narumiya, S., and Ichikawa, A. Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP2.(1999) Proc. Natl. Acad. Sci. USA.96, 10501-10506
• Ishibashi, R., Tanaka, I., Kotani, M., Muro, S., Goto, M., Sugawara, A., Mukoyama, M., Sugimoto, Y., Ichikawa, A., Narumiya, S., and Nakao, K. Roles of prostaglandin E receptors in mesangial cells under high-glucose conditions.(1999) Kidney Int.56, 589-600
• Takeuchi, K., Ukawa, H., Furukawa, O., Kawauchi, S., Araki, H., Sugimoto, Y., Ichikawa, A., Ushikubi, F., and Narumiya, S. Prostaglandin E receptor subtypes involved in stimulation of gastroduodenal bicarbonate secretion in rats and mice.(1999) J. Physiol. Pharmacol.50, 155-167
• Hosokawa, H., Ninomiya, H., Sawamura, T., Sugimoto, Y., Ichikawa, A., Fujiwara, K., and Masaki, T. Neuron-specific expression of cationic amino acid transporter 3 in the adult rat brain.(1999) Brain Res.838, 158-165

 

1998

• Sugimoto, Y., Segi, E., Tsuboi, K., Ichikawa, A., and Narumiya, S. Female reproduction in mice lacking the prostaglandin F receptor; roles of prostaglandin and oxytocin receptors in parturition.(1998) Adv. Exp. Med. Biol.449, 317-321
• Katsuyama, M., Ikegami, R., Karahashi, H., Amano, F., Sugimoto, Y., and Ichikawa, A. Characterization of the LPS-stimulated expression of EP2 and EP4 prostaglandin E receptors in mouse macrophage-like cell line, J774.1.(1998) Biochem. Biophys. Res. Commun.251, 727-731
• Ushikubi, F., Segi, E., Sugimoto, Y., Murata, T., Matsuoka, T., Kobayashi, T., Hizaki, H., Tuboi, K., Katsuyama, M., Ichikawa, A., Tanaka, T., Yoshida, N., and Narumiya, S. Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3.(1998) Nature. 395, 281-284
• Segi, E., Sugimoto, Y., Yamasaki, A., Aze, Y., Oida, H., Nishimura, T., Murata, T., Matsuoka, T., Ushikubi, F., Hirose, M., Tanaka, T., Yoshida, N., Narumiya, S., and Ichikawa, A. Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice.(1998) Biochem. Biophys. Res. Commun. 246, 7-12
• Katsuyama, M., Sugimoto, Y., Okano, K., Segi, E., Ikegami, R., Negishi, M., and Ichikawa, A. Characterization of the gene for the mouse prostaglandin E receptor subtype EP2: tissue specific alternative transcripts in the macrophage and the uterus.(1998) Biochem. J. 330, 1115-1121

 

1997

• Oida, H., Hirata, M., Sugimoto, Y., Ushikubi, F., Ohishi, H., Mizuno, N., Ichikawa, A., and Narumiya, S. Expression of messenger RNA for the prostaglandin D receptor in the leptomeninges of the mouse brain.(1997) FEBS Lett. 417, 53-56
• Hasumoto, K., Sugimoto, Y., Gotoh, M., Segi E., Yamasaki, A., Yamaguchi, M., Honda, H., Hirai, H., Negishi, M., Kakizuka, A., and Ichikawa, A. Characterization of the mouse prostaglandin F receptor gene: a transgenic mouse study of a regulatory region that controls its expression in the stomach and kidney but not in the ovary.(1997) Genes Cells. 2, 571-580
• Sugimoto, Y., Yamasaki, A., Segi, E., Tsuboi, K., Aze, Y., Nishimura, T., Oida, H., Yoshida, N., Tanaka, T., Katsuyama, M., Hasumoto, K., Murata, T., Hirata, M., Ushikubi, F., Negishi, M., Ichikawa, A., and Narumiya, S. Failure of parturition in mice lacking the prostaglandin F receptor.(1997) Science. 277, 681-684
• Murata, T., Ushikubi, F., Matsuoka, T., Hirata, M., Yamasaki, A., Sugimoto, Y., Ichikawa, A., Aze, Y., Tanaka, T., Yoshida, N., Ueno, A., Oh-ishi, S., and Narumiya, S. Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. (1997) Nature. 388, 678-682
• Kiriyama, M., Ushikubi, F., Kobayashi, T., Hirata, M., Sugimoto, Y., and Narumiya, S. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. (1997) Br. J. Pharmacol. 122, 217-224
• Ding, M., Kinoshita, Y., Kishi, K., Nakata, H., Hassan, S., Kawanami, C., Sugimoto, Y., Katsuyama, M., Negishi, M., Narumiya, S., Ichikawa, A., and Chiba, T. Distribution of prostaglandin E receptors in the rat gastrointestinal tract. (1997) Prostaglandins. 53, 199-216
• Yang, Z.-M., Das, S.K., Wang, J., Sugimoto, Y., Ichikawa, A., and Dey, S.K. Potential sites of prostaglandin actions in the periimplantation mouse uterus: differential expression and regulation of prostaglandin receptor genes. (1997) Biol. Reprod. 56, 368-379
• Morimoto, K., Sugimoto, Y., Katsuyama, M., Oida, H., Tsuboi, K., Kishi, K., Kinoshita, Y., Negishi, M., Chiba, T., Narumiya, S., and Ichikawa, A. Cellular localization of mRNAs for the prostaglandin E receptor subtypes in the mouse gastrointestinal tract. (1997) Am. J. Physiol. 272, G681-G687
• Hasumoto, K., Sugimoto, Y., Yamasaki, A., Morimoto, K., Kakizuka, A., Negishi, M., and Ichikawa, A. Expression of mRNA encoding PGF2alpha receptor associates with luteal cell apoptosis in the ovary of the pseudopregnant mouse. (1997) J. Reprod. Fertil. 109, 45-51
• Katsuyama, M., Sugimoto, Y., Morimoto, K., Hasumoto, K., Fukumoto, M., Negishi, M., and Ichikawa, A. Distinct cellular localization of the mRNAs for prostaglandin E receptor subtypes in the mouse uterus during pseudopregnancy. (1997) Endocrinology. 138, 344-350

 

1996

• Ichikawa, A., Sugimoto, Y., and Negishi, M. Molecular aspects of the structures and functions of the prostaglandin E receptors. (1996) J. Lipid Mediat. Cell Signal. 14, 83-87
• Momiyama, T., Todo, N., Sugimoto, Y., Ichikawa, A., and Narumiya, S. Membrane depolarization by activation of prostaglandin E receptor EP3 subtype of putative serotonergic neurons in the dorsal raphe nucleus of the rat. (1996) Naunyn-Schmiedeberg's Arch. Pharmacol. 353, 377-381
• Ishikawa, T. O., Tamai, Y., Rochelle, J. M., Hirata, M., Namba, T., Sugimoto, Y., Ichikawa, A., Narumiya, S., Taketo, M. M., and Seldin, M. F. Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors. (1996) Genomics.32, 285-288.

 

1995

• Negishi, M., Sugimoto, Y., and Ichikawa, A. Prostaglandin E receptors.(1995) J. Lipid Mediat. Cell Signal. 12, 379-391
• Negishi, M., Sugimoto, Y., and Ichikawa, A. Molecular mechanisms of diverse actions of prostanoid receptors.(1995) Biochim. Biophys. Acta. 1259, 109-120
• Negishi, M., Sugimoto, Y., Namba, T., Irie, A., Narumiya, S., and Ichikawa, A. Signal transductions of three isoforms of mouse prostaglandin E receptor EP3 subtype.(1995) Adv. Prostaglandin Thromboxane Leukot. Res. 23, 255-257
• Oida, H., Namba, T., Sugimoto, Y., Ushikubi, F., Ohishi, H., Ichikawa, A., and Narumiya, S. In situ hybridization studies of prostacyclin receptor mRNA expression in various mouse organs.(1995) Br. J. Pharmacol.116, 2828-2837
• Katsuyama, M., Nishigaki, N., Sugimoto, Y., Morimoto, K., Negishi, M., Narumiya, S., and Ichikawa, A. The mouse prostaglandin E receptor EP2 subtype: cloning, expression, and Northern blot analysis.(1995) FEBS Lett.372, 151-156
• Naribayashi-Inomoto Y., Ding, M., Nakata, H., Narumiya, S., Sugimoto, Y., Honda, A., Ichikawa, A., Chiba, T., and Kinoshita, Y. Copresence of prostaglandin EP2 and EP3 receptors on gastric enterochromaffin-like cell carcinoid in African rodents.(1995) Gastroenterology.109, 341-347
• Negishi, M., Harazono, A., Sugimoto, Y., Hazato,A., Kurozumi,S., and Ichikawa, A. Selective coupling of prostaglandin E receptor EP3D to multiple G proteins depending on interaction of the carboxylic acid of agonist and arginine residue of seventh transmembrane domain.(1995) Biochem. Biophys. Res. Commun.212, 279-285
• Kitanaka, J., Hashimoto, H., Sugimoto, Y., Sawada, M., Negishi, M., Suzumura, A., Marunouchi, T., Ichikawa, A., and Baba, A. cDNA cloning of a thromboxane A2 receptor from rat astrocytes.(1995) Biochim. Biophys. Acta.1265, 220-223
• Negishi, M., Irie, A., Sugimoto, Y., Namba, T., and Ichikawa, A. Selective coupling of prostaglandin E receptor EP3D to Gi and Gs through interaction of α-carboxylic acid of agonist and arginine residue of seventh transmembrane domain. (1995) J. Biol. Chem.270, 16122-16127
• Katoh, H., Watabe, A., Sugimoto, Y., Ichikawa, A., and Negishi, M. Characterization of the signal transduction of prostaglandin E receptor EP1 subtype in cDNA-transfected Chinese hamster ovary cells. (1995) Biochim. Biophys. Acta.1244, 41-48
• Nishigaki, N., Negishi, M., Honda, A., Sugimoto, Y., Namba, T., Narumiya, S., and Ichikawa, A. Identification of prostaglandin E receptor "EP2" cloned from mastocytoma cells as EP4 subtype. (1995) FEBS Lett..364, 339-341

 

 

1994

• Negishi, M., Harazono, A., Sugimoto, Y., Hazato, A., Kurozumi, S., and Ichikawa, A. TEI-3356, a highly selective agonist for the prostaglandin EP3 receptor. (1994) Prostaglandins.48, 275-283
• Kitanaka, J., Hashimoto, H., Sugimoto, Y., Negishi, M., Aino, H., Gotoh, M., Ichikawa, A., and Baba, A. Cloning and expression of a cDNA for rat prostaglandin F2a receptor.(1994) Prostaglandins.48, 31-41
• Irie, A., Segi, E., Sugimoto, Y., Ichikawa, A., and Negishi, M. Mouse prostaglandin E receptor EP3 subtype mediates calcium signals via Gi in cDNA-transfected Chinese hamster ovary cells.(1994) Biochem. Biophys. Res. Commun.204, 303-309
• Sugimoto, Y., Shigemoto, R., Namba, T., Negishi, M., Mizuno, N., Narumiya, S., and Ichikawa, A. Distribution of the messenger RNA for the prostaglandin E receptor subtype EP3 in the mouse nervous system.(1994) Neuroscience.62, 919-928
• Irie, A., Sugimoto, Y., Namba, T., Asano, T., Ichikawa, A., and Negishi, M. The C-terminus of the prostaglandin-E-receptor EP3 subtype is essential for activation of GTP-binding protein.(1994) Eur. J. Biochem.224, 161-166
• Harazono, A., Sugimoto, Y., Ichikawa, A., and Negishi, M. Enhancement of adenylate cyclase stimulation by prostaglandin E receptor EP3 subtype isoforms with different efficiencies. (1994) Biochem. Biophys. Res. Commun.201, 340-345. (1994)
• Sando, T., Usui, T., Tanaka, I., Mori, K., Sasaki, Y., Fukuda, Y., Namba, T., Sugimoto, Y., Ichikawa, A., Narumiya, S., and Nakao, K. Molecular cloning and expression of rat prostaglandin E receptor EP2 subtype. (1994) Biochem. Biophys. Res. Commun.200, 1329-1333. (1994)
• Katsuyama, M., Sugimoto, Y., Namba, T., Irie, A., Negishi, M., Narumiya, S., and Ichikawa, A. Cloning and expression of a cDNA for the human prostacyclin receptor. (1994) FEBS Lett..344, 74-78. (1994)
• Sugimoto, Y., Namba, T., Shigemoto, R., Negishi, M., Ichikawa, A., and Narumiya, S. Distinct cellular localization of the mRNAs for three subtypes of prostaglandin E receptor in kidney.(1994) Am. J. Physiol.266, F823-F828. (1994)
• Namba, T., Oida, H., Sugimoto, Y., Kakizuka, A., Negishi, M., Ichikawa, A., and Narumiya, S. cDNA cloning of a mouse prostacyclin receptor: multiple signaling pathways and expression in thymic medulla.(1994) J. Biol. Chem.269, 9986-9992. (1994)
• Sugimoto, Y., Hasumoto, K., Namba, T., Irie, A., Katsuyama, M., Negishi, M., Kakizuka, A., Narumiya, S., and Ichikawa, A. Cloning and expression of a cDNA for mouse prostaglandin F receptor. (1994) J. Biol. Chem.269, 1356-1360. (1994)
• Taketo, M., Rochelle, J.M., Sugimoto, Y., Namba, T., Honda, A., Negishi, M., Ichikawa, A., Narumiya, S., and Seldin, M.F. Mapping of the genes encoding mouse thromboxane A2 receptor and prostaglandin E receptor subtypes EP2 and EP3.(1994) Genomics.19, 585-588.

 

1993

• Negishi, M., Namba, T., Sugimoto, Y., Irie, A., Katada, T., Narumiya, S., and Ichikawa, A. Opposite coupling of prostaglandin E receptor EP3c with Gs and Go. (1993) J. Biol. Chem.268, 26067-26070.
• Irie, A., Sugimoto, Y., Namba, A., Harazono, A., Honda, A., Watabe, A., Negishi, M., Narumiya, S., and Ichikawa, A. Third isoform of the prostaglandin-E-receptor EP3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase. (1993) Eur. J. Biochem.217, 313-318.
• Negishi, M., Sugimoto, Y., and Ichikawa, A. Prostanoid receptors and their biological actions. (1993) Prog. Lipid Res.32, 417-434.
• Watabe, A., Sugimoto, Y., Honda, A., Irie, A., Namba, T., Negishi, M., Ito, S., Narumiya, S., and Ichikawa, A. Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor. (1993) J. Biol. Chem.268, 20175-20178.
• Namba, T., Sugimoto, Y., Negishi, M., Irie, A., Ushikubi, F., Kakizuka, A., Ito, S., Ichikawa, A., and Narumiya, S. Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity. (1993) Nature.365, 166-170.
• Nishigaki, N., Negishi, M., Sugimoto, Y., Namba, T., Narumiya, S., and Ichkawa, A. Characterization of the prostaglandin E receptor expressed on a cultured mast cell line, BNu-2cl3. (1993) Biochem. Pharmacol.46, 863-869.
• Narumiya, S., Hirata, N., Namba, T., Hayashi, Y., Ushikubi, F., Sugimoto, Y., Negishi, M., and Ichikawa, A. Structure and function of prostanoid receptors.(1993) J. Lipid Mediat.6, 155-161.
• Negishi, M., Sugimoto, Y., Irie, A., Narumiya, S., and Ichikawa, A. Two isoforms of prostaglandin E receptor EP3 subtype; Different C-terminal domains determine sensitivity to agonist-induced desensitization.(1993) J. Biol. Chem.268, 9517-9521.
• Honda, A., Sugimoto, Y., Namba, T., Watabe, A., Irie, A., Negishi, M., Narumiya, S., and Ichikawa, A. Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype.(1993) J. Biol. Chem.268, 7759-7762.
• Negishi, M., Sugimoto, Y., Hayashi, Y., Namba, T., Honda, A., Watabe, A., Narumiya, S., and Ichikawa, A. Functional interaction of prostaglandin E receptor EP3 subtype with guanine nucleotide binding proteins, showing low affinity ligand binding. (1993) Biochim. Biophys. Acta.1175, 343-350.
• Sugimoto, Y., Negishi, M., Hayashi, Y., Namba, T., Honda, A., Watabe, A., Hirata, M., Narumiya, S., and Ichikawa, A. Two isoforms of EP3 receptor with different C-terminal domains; identical ligand binding properties and different coupling properties with Gi proteins.(1993) J. Biol. Chem.268, 2712-2718.
• Zhang, J., Nomura, T., Yatsunami, K., Honda, A., Sugimoto, Y., Moriwaki, T., Yamamoto, J., Ohta, M., Fukui, T., and Ichikawa, A. Nucleotide sequence of the cDNA encoding nucleoside diphosphate kinase II derived from spinach leaves.(1993) Biochim. Biophys. Acta.1171, 304-306.

 

1992

• Nomura, T., Yatsunami, K., Honda, A., Sugimoto, Y., Fukui, T., Yamamoto, J., and Ichikawa, A. The amino acid sequence of nucleoside diphosphate kinase I from spinach leaves as deduced from cDNA sequence. (1992) Arch. Biochem. Biophys.297, 42-45.
• Namba, T., Sugimoto, Y., Hirata, M., Hayashi, Y., Honda, A., Watabe, A., Negishi, M., Ichikawa, A., and Narumiya, S. Mouse thromboxan A2 receptor; cDNA cloning, expression and northern blot analysis. (1992) Biochem. Biophys. Res. Commun.184, 1197-1203.
• Sugimoto, Y., Namba, T., Honda, A., Hayashi, Y., Negishi, M., Ichikawa, A., and Narumiya, S. Cloning and expression of a cDNA for mouse prostaglandin E receptor EP3 subtype.(1992) J. Biol. Chem.267, 6463-6466.

 

1991

• Sugimoto, Y., Yatsunami, K., Tsujimoto, M., Khorana, H.G., and Ichikawa, A. The amino acid sequence of a glutamic acid-rich protein from bovine retina as deduced from the cDNA sequence.(1991) Proc. Natl. Acad. Sci. USA.88, 3116-3119.

 

1990

• Yamamoto, J., Yatsunami, K., Ohmori, E., Sugimoto, Y., Fukui, T., Katayama, T., and Ichikawa, A. cDNA-derived amino acid sequence of L-histidine decarboxylase from mouse mastocytoma P-815 cells. (1990) FEBS Lett..276, 214-218.

• Matsumoto, R., Dainichi, T., Tsuchiya, S., Nomura, T., Kitoh, A., Hayden, M.S., Ishii, K.J., Tanaka, M., Honda, T., Egawa, G., Otsuka,A., Nakajima, S., Sakurai, K., Nakano, Y., Kobayashi, T., Sugimoto, Y., Kabashima, K.　Epithelial TRAF6 drives IL-17-mediated psoriatic inflammation. JCI Insight. 3, e121175. (2018)
• Inazumi, T., Sugimoto, Y.　Cross-talk between prostaglandin and retinoic acid signaling. Carotenoid Sci. 23, in press. (2018)