発表論文 - 2020年
- Mohassab AM, Hassan HA, Abdelhamid D, Gouda AM, Youssif BGM, Tateishi H, Fujita M, Otsuka M, and Abdel-Aziz M.
Design and synthesis of novel quinoline/chalcone/1,2,4-triazole hybrids as potent antiproliferative agent targeting EGFR and BRAFV600E kinases.
Bioorganic Chemistry, in press.
- Sever B, Altintop MD, Ozdemir A, Ciftci GA, Ellakwa DE, Tateishi H, Radwan MO, Ibrahim MAA, Otsuka M, Fujita M, Ciftci HI, and Ali TFS.
In vitro and in silico evaluation of anticancer activity of new indole-based 1,3,4-oxadiazoles as EGFR and COX-2 inhibitors.
Molecules 25: 5190, 2020.
- Mingle D, Ospanov M, Radwan MO, Ashpole N, Otsuka M, Ross SA, Walker LA, Abbas G, Shilabin, and Ibrahim MA.
First in class (S,E)-11-[2-(arylmethylene)hydrazono]-PBD analogs as selective CB2 modulators targeting neurodegenerative disorders.
Medicinal Chemistry Research, in press.
- Zeytun E, Altintop MD, Sever B, Ozdemir A, Ellakwa DE, Ocak Z, Ciftci HI, Otsuka M, Fujita M, and Radwan MO.
A new series of antileukemic agents: Design, synthesis, in vitro and in silico evaluation of thiazole-based ABL1 kinase inhibitors.
Anti-Cancer Agents in Medicinal Chemistry, in press.
- Radwan MO, Ciftci HI, Ali TFS, Koga R, Tateishi H, Nakata A, Ito A, Yoshida M, Fujita M, and Otsuka M.
Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition.
Bioorganic & Medicinal Chemistry Letters, in press.
- Shimagaki K, Koga R, Fujino H, Ahagon A, Tateishi H, Otsuka M, Yamaguchi Y, and Fujita M.
The stability of HIV-2 Vpx and Vpr proteins is regulated by the presence or absence of zinc-binding sites and poly-proline motifs with distinct roles.
Journal of General Virology, in press.
- Imai M, Kato K, Yamaguchi Y, Fujita M, Otsuka M, and Kurosaki H.
Activation of ligand reaction on an iron complex: H/D exchange reaction of a low-spin bis[2-(pyridylmethylidene)-1-(2-pyridyl)methylamine]iron(II) complex.
Chemical and Pharmaceutical Bulletin, in press.
- El-Shaheny R, Radwan MO, Belal F, and Yamada K.
Pentabromobenzyl-RP versus triazole-HILIC columns for separation of the polar basic analytes famotidine and famotidone: LC method development combined with in silico tools to follow the potential consequences of famotidine gastric instability.
Journal of Pharmaceutical and Biomedical Analysis 186: 113305, 2020.
- Nakamura T, Hashikawa C, Okabe K, Yokote Y, Chirifu M, Toma-Fukai S, Nakamura N, Matsuo M, Kamikariya M, Okamoto Y, Gohda J, Akiyama T, Semba K, Ikemizu S, Otsuka M, Inoue J, and Yamagata Y.
Structural analysis of TIFA: Insight into TIFA-dependent signal transduction in innate immunity.
Scientific Reports 10: 5152, 2020.
- Radwan MO, Takaya D, Koga R, Iwamaru K, Tateishi H, Ali TFS, Takaori-Kondo A, Otsuka M, Honma T, and Fujita, M.
Interruption of Vif/Elongin C interaction: In silico and experimental elucidation of the underlying molecular mechanism of benzimidazole-based APOBEC3G stabilizers.
Bioorganic & Medicinal Chemistry 28: 115409, 2020.
- Ciftci HI, Can M, Ellakwa D, Suner S, Ibrahim M, Oral A, Sekeroglu N, Ozalp B, Otsuka M, Fujita M, Alparslan M, and Radwan M.
Antiproliferative activity of Turkish marine extracts: A purple sponge components induce apoptosis with multiple kinases inhibition.
Investigational New Drugs, in press.
- Ali TFS, Taira N, Iwamaru K, Koga R, Kamo M, Radwan MO, Tateishi H, Kurosaki H, Abdel-Aziz M, Abuo-Rahma GEAA, Beshr EAM, Otsuka M, and Fujita M.
HSP70 induction by bleomycin metal core analogs.
Bioorganic & Medicinal Chemistry Letters 30: 127002, 2020.
Bayrak N, Yildirim H, Yildiz M, Radwan MO, Otsuka M, Fujita M, Ciftci HI, and Tuyun AF.
A novel series of chlorinated plastoquinone analogs: Design, synthesis, and evaluation of anticancer activity.
Chemical Biology & Drug Design 95: 343-354, 2020.