Department of Physical Pharmaceutics - Faculty of Life Sciences Kumamoto University

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Doctoral Degree

Doctoral Degree (granted after the completion of five-year Ph.D. program in the Graduate School of Pharmaceutical Sciences in Kumamoto University)

  1. Masahiko Kikuchi
    Improvement of Pharmaceutical Properties of an Anticancer Agent, Carmofur, by Complexation with Methylated β-Cyclodextrin (1989).
  2. Atsuya Yoshida
    Pharmaceutical Evaluation of Hydroxyalkylated β-Cyclodextrin Derivatives as Parenteral Drug Carrier (1990).
  3. Hidetoshi Arima
    Improvements of Percutaneuos and Rectal Absorptions of Anti-inflammatory Agents, 4-Biphenylylacetic Acid and its Ester, by Water-Soluble Cyclodextrin Derivatives and Elucidation of Their Absorption-enhancing Mechanism (1991).
  4. Yasuhide Horiuchi
    Release Control of Drugs by Complexation with Hydrophobic Di-O-ethyl- and Tri-O-ethyl-β-cyclodextrins and Ionizable O-Carboxymethyl-O-ethyl-β-cyclodextrin (1991).
  5. Masanobu Yamamoto
    Pharmaceutical Evaluation of Branched β-Cyclodextrins as Parenteral Drug Carrier (1992).
  6. Hirotoshi Adachi
    Potential Use of O-Carboxymethyl-O-ethyl-β-cyclodextrin in Transderaml Drug Delivery for Prostaglandin E1 (1993).
  7. Tadanobu Utsuki
    Topological Control of Photoisomerization and Photodimerization of Drugs by Complexation with Cyclodextrins (1993).
  8. Zheng Wang
    Improvement of Solid Properties of Nifedipine by Complexation with 2-Hydroxypropyl-β-cyclodextrin and Design of Controlled-release Preparations (1994).
  9. Kazufumi Shiotani
    Pharmaceutical Evaluation of β-Cyclodextrin Sulfates and Sulfobutyl Ether β-Cyclodextrin as Parenteral Drug Carrier (1995).
  10. Takashi Horikawa
    In Vitro and In Vivo Evaluations of Hydrophobic Peracylated β-Cyclodextrins and O-Carboxymethyl-O-ethyl-β-cyclodextrin as Sustained- and Delayed-release Carriers (1995).
  11. Kazuya Abe
    Potential Use of Hydroxypropyl-β-cyclodextrin in Enhancing Nasal Absorption of Peptides and Reducing Local Irritation by Combination with Lipophilic Absorption Enhancers (1996).
  12. Takashi Kondo
    Modification of Rectal and Nasal Absorption of Morphine with Cyclodextrin Derivatives (1996).
  13. Keiichi Tokihiro
    Potential Use of Hydrophilic Cyclodextrins in Controlling Self-association of Insulin and Its Subcutaneous Absorption (1997).
  14. Kunihiro Minami
    Design and Evaluation of Colon-specific Drug Delivery System Based on Cyclodextrin Conjugates (1998).
  15. Kouzou Miyake
    Improvement of Solubility and Oral Bioavailability of Poorly Water-soluble Drugs, Itraconazole and Cyclosporin A, by Complexation with Cyclodextrin Derivatives (1999).
  16. Kenya Kimura
    Control of Crystallization and Polymorphic Transition of Tolbutamide by Inclusion Complexation with 2-Hydroxypropylated Cyclodextrins (2000).
  17. Wenge Liu
    Role of Activated Neutrophils in Water-immersion Restraint Stress-induced Gastric Mucosal Injury (2000).
  18. Naomi Ono
    Model Analysis for Oral Absorption of Drug/Cyclodextrin Complex Involving Competitive Inclusion (2001).
  19. Hideki Yano
    Evaluation of Drug/Cyclodextrin Conjugates as Delayed Release Type Prodrugs (2001).
  20. Fumihiro Kihara
    Molecular Design and Evaluation of Cyclodextrin/Dendrimer Conjugates as Non-viral Vectors for Gene Transfer (2003).
  21. Kiyokazu Yunomae
    Contribution of Multidrug Effix Pump to the Enhancing Effects of Cyclodextrin on Oral Bioavailability of Tacrolimus (2003).
  22. Koki Wada
    Evaluation of Mannosylated Dendrimer/α-Cyclodextrin Conjugates as Gene Transfer Carrier and Elucidation of Enahancemnet Machanism (2005).
  23. Kinsei Anzai
    Solid-state Inclusion Complexation of A New Helicobacter Pylori Eradication Agent, 4-Methylbenzyl 4'-[trans-4-(guanidinomethyl)cyclohexylcarbonyloxy]biohenyl-4-carboxylate monohydrochloride (TG44), with β-Cyclodextrin and Its Preformulation (2005).
  24. Sumitra Tavornvipas
    Improvement of Pharmaceutical Properties of Protein Drugs by Branched β-Cyclodextrin (2005).
  25. Yo Sonoda
    Selective Preparation of Metastable Crystals of Oral Hypoglycemic Agents Utilizing Cyclodextrin Complexation (2006).
  26. Takumi Hara
    Involvement of Bile Acids in the Enhanced Oral Bioavailability of A New Antidiabetic Agent, 2-(N-Cyanoimino)-5-{(E)-4-styrylbenzylidene}-4-oxothiazolidine (FPFS-410) by Inclusion Complexation with 2-hydroxypropyl-β-cyclodextrin (2006).
  27. Yoshiyuki Hagiwara
    Modification of Biopharmaceutical Properties of Drugs Using Liposomes Entrapping Their Complexes or Their Conjugates with γ-Cyclodextrin (2006).
  28. Keiichi Motoyama
    Potential Use of 2,6-Di-O-methyl-3-O-acetyl-β-cyclodextrin as a New Therapeutic Agent for Endotoxin Shock Induced by LPS (2006).
  29. Toshihito Tsutsumi
    Evaluation of Dendrimer/a-cyclodextrin Conjugate as a Novel Carrir of Short Haipin RNA-expressing Plasmid Vectors and siRNAs (2007).
  30. katsunori Nishimura
    Studies on Improvement of Physicochemical Properties of Poorly Water-soluble Drugs by SUpramolecular Complex Formation with Cyclodextrins and Potential Use of Cyclodextrin Complex in Semi-solid Dosage Forms(2008).
  31. Taishi Higashi
    Design and Evaluation of Sustained Release System for PEGylated Proteins Utilizing Cyclodextrin Polypseudorotaxane (2009).
  32. Koichi Udo
    Design and Evaluation of Cyclodextrin Conjugates Used as Anti-inflammatory Drug and Anti-cancer Drug in the Colon-specific Delivery System (2010).
  33. Yuji Miyamoto
    Study on Bitter/irritating Masking of Antihistaminic Drugs and Arundic Acid by Complexation with Cyclodextrins (2010).
  34. Takako Ishiguro
    Pharmaceutical Evaluation of 2-Hydroxypropyl-b-cyclodextrin and Its Application to Control of Polymorphic Transition (2011).
  35. Keiko Uehata
    Potential Use of Hydrophilic Cyclodextrins for Improvement of Pharmaceutical Properties of Insulin Glargine (2011).
  36. Takayuki Anno
    Preparation and Evaluation of Dendrimer/Branched b-Cyclodextrin Conjugates for Treatment of Familial Amyloidotic Polyneuropathy: Application as a Gene or siRNA Carrier and an Inhibitor of Amyloid Fibril Formation of Transthyretin (2012).
  37. Risako Onodera
    Disign and Evaluation of Folate-appended Methyl-b-cyclodextrin as a Novel Anitumor Drug Carrier for Tumor Cells and an Antitumor Agent (2013).

Doctoral Degree (in recognition of the fulfilment of a Ph.D. dissertation in Kumamoto University)

  1. Teruhiko Hoshino
    Potential Use of Di-O-methyl-β-cyclodexrtin in Alleviating Photosensitized Skin Irritation and Hemolysis of Drugs (1989).
  2. Hakaru Seo
    Improvement of Bioavailability of Poorly Water-soluble Drugs by Complexation with Cyclodextrin/Epichlorohydrin Polymers (1990).
  3. Ichimaro Yamada
    Evaluation of Oral Bioavailability of Solid Drugs Using Gastric Acidity Controlled Beagle Dogs (1990).
  4. Hiroaki Mizuta
    A New Technique for Estimating Gastrointestinal Transition Time of Drugs in Beagle Dogs and Its Application to Evaluation of Oral Bioavailability (1991).
  5. Masahiko Kurihara
    Improvement of Chemical Stability of Prostaglandins by Methylated Cyclodextrins (1994).
  6. Kazuhiro Fukunaga
    Potential Use of Amorphous Cyclodextrin Derivatives in Pharmaceutical Preparations (1994).
  7. Shinji Narisawa
    Design and Evaluation of New Oral Controlled-release Preparations Using Porosity-controlled Ethylcellulose Film Coating (1994).
  8. Naruhito Higo
    Studies on Cutaneous Drug Metabolism and Evaluation of Penetration Enhancer Actions in Transdermal Drug Delivery (1995).
  9. Hiroyuki Sugiuchi
    Development and Clinical Study of Analytical Method of Biochemical Markers for Acute Myocardial Infarction (1995).
  10. Keishi Hata
    Basic Study for the Development of New Method for Measuring Bone Metabolic Markers in Human Serum and Urine (1996).
  11. Kazutaka Matsubara
    Potential Use of Cyclodextrin Derivatives in Design of Transmucosal and Controlled-release Type Formulations of Buserelin Acetate (1997).
  12. Jiro Fujisaki
    Design and Evaluation of Osteotropic Drug Delivery System (1997).
  13. Kazuto Okimoto
    Design and Evaluation of Controlled-porosity Osmotic Pump Tablets Using Sulfobutyl Ether-β-cyclodextrin (1999).
  14. Yoichi Ikeda
    Inclusion Complex Formation of Water-soluble Drugs with Hydrophilic Cyclodextrins and Their Application to Controlled Drug Release System (2004).
  15. Yukihiko Nagase
    Utilization of Sulfobutyl Ether-β-Cyclodextrin as Drug Carrier in Parenteral Formulation (2005).
  16. Kengo Ikegami
    Bioavailability Studies of Controlled-Release Multiple Unit Dosage Forms: Construction of In-vitro/In-vivo Evaluation Method (2006).
  17. Noboru Sekiya
    Improved Stability of Opalmon Tablets under Humid Condition (2007).
  18. Shinichiro Tajiri
    Formulation of Extended-Release Press-Coated Tablets and Establishment of Novel Methods for Estimating Gastrointestinal Absorption Behavior in Beagle Dogs (2010).

Doctoral Degree (in recognition of the fulfilment of a Ph.D. dissertation in other Universities)

  1. Fumitoshi Hirayama
    Improvement of Pharmaceutical Properties ofProstaglandins by Complexation with Cyclodextrins (from Kyushu University,1982).
  2. Tetsumi Irie
    Potential Use of Cyclodextrins in AlleviatingLocal Irritation of Phenothiazines and Elucidation of Their AlleviationMechanism (from Nagoya City University, 1986).
  3. Teruko Imai
    Improvement of Pharmaceutical Properties ofAn Anti-inflammatory Drug, Flurbiprofen, by Complexation with Cyclodextrins(from Kyushu University, 1988).
  4. Kohji Inaba
    Improvement of Solubility and Stability ofProstaglandins by Complexation with Cyclodextrins (from Hoshi University,1988).
  5. Masao Ueno
    Utilization of Hydrophobic Alkylated CyclodextrinDerivatives in Preparation of Oral Dosage Forms (from Josai University,1990).
  6. Takuya Kukita
    Studies on Adsorption of Bromhexine Hydrochlorideon Packing Materials (from Chiba University, 1993).
  7. Muneo Tanaka
    Potential Use of 2-Hydroxypropyl-β-cyclodexrinin Cosmetics (from Tokyo University of Pharmacy, 1997).
  8. Osama A.E. Soliman
    Release Control of Water-soluble Drugs by the Combination of Hydrophilic and Hydrophobic Cyclodextrins (from Mansoura University, Egypt, 1998).
  9. Kazuhiro Sako
    Research and Development of Oral Controlled-Release System for Continuous Absorption Utilizing Colonic drug Absorption (from Institute for Pharmaceutical Sciences，University of Shizuoka, 2002).
  10. Shuichi Yada
    Pharmaceutical studies on amorphization by polymorphism and grinding of CS-891(from University of Chiba, 2003).