Department of Physical Pharmaceutics - Faculty of Life Sciences Kumamoto University

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Publications

  • Supramolecular Pharmaceutical Sciences: A Novel Concept Combining Pharmaceutical Sciences and Supramolecular Chemistry with Focus on Cyclodextrin-based Supermolecules (Review)
    T. Higashi, D. Iohara, K. Motoyama, H. Arima
    Chem. Pharm. Bull., 66(3), 207-216 (2018).
  • Potential Therapeutic Application of Dendrimer/Cyclodextrin Conjugates with Targeting Ligands as Advanced Carriers for Gene and Oligonucleotides Drugs
    H. Arima、K. Motoyama, T. Higashi
    Ther. Deliv., 8(4), 215-232 (2017).
  • Potential Use of Cyclodextrins as Drug Carriers and Active Pharmaceutical Ingredientss (Review)
    H. Arima, K. Motoyama, T. Higashi
    Chem. Pharm. Bull., 65(4), 341-348 (2017).
  • Cyclodextrin-based drug carriers for low molecular weight drugs, proteins, and nucleic acids.
    T. Higashi, K. Motoyama, H. Arima
    Methods in Pharmacology and Toxicology, 39, 27-45 (2016).
  • Recent Advances in Cyclodextrin Delivery Techniques H. Arima, Y. Hayashi, T. Higashi, K. Motoyama
    Expert Opin. Drug Deliv., 12(9), 1425-1441 (2015).
  • Cyclodextrin/Dendrimer Conjugates As DNA And Oligonucleotide Carriers. H. Arima, K. Motoyama, T. Higashi
    Curr. Top. Med. Chem., 14(4), 465-477 (2014).
  • Cyclodextrin-based Polyrotaxanes and Polypseudorotaxanes as Drug Delivery Carriers. T. Higashi, K. Motoyama, H. Arima
    J. Drug Deliv. Sci. Tech., 23(6), 523-529 (2013).
  • Sugar-appended polyamidoamine dendrimer conjugates with cyclodextrins as cell-specific non-viral vectors H. Arima, K. Motoyama, T. Higashi
    Adv. Drug Deliv. Rev., 65(9), 1204-1214 (2013).
  • Improvement of the bitter tast of drugs by complexation with cyclodextrins: application, evaluations and mechanisms (Review) H. Arima, T. Higashi, K. Motoyama
    Therapeutic Delivery , 3(5), 633-644 (2012).
  • Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for DNA, shRNA and siRNA H. Arima, K. Motoyama, T. Higashi
    Pharmaceutics, 4(1), 130-148 (2012).
  • Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA (Review) H. Arima, K. Motoyama, T. Higashi
    Pharmaceuticals, 5(1), 61-78 (2012).
  • DDS of siRNA : Cyclodextrin/Dendrimer Conjugate
    H. Arima, K. Motoyama
    Drug Delivery System, 26(6), 598-606 (2010).
  • Recent Findings of PAMAM Dendrimer Conjugates with Cyclodextrins as Carriers of DNA and RNA
    H. Arima, K. Motoyama
    Sensors, 9, 6346-6361 (2009).
  • Recent Aspect of Cyclodextrin-based Drug Delivery System
    K. Uekama, F. Hirayama, H. Arima
    J. Incl. Phenom. Macrocycl. Chem., 56, 3-8 (2005).
  • Design and evaluation of cyclodextrin-based drug formulation.
    K. Uekama
    Chem. Pharm. Bull.,52 (8), 900-915 (2004). abstract
  • Recent Aspects of Cyclodextrin-based Pharmaceutical Formulations.
    H. Arima, F. Hirayama C. T. Okamoto and K. Uekama:
    Recent Res. Devel. Chem. Pharm. Sciences, 2, 55-193 (2002). abstract
  • Cyclodextrins in Drug Delivery System: Preface.
    K. Uekama: Adv. Drug Deliv. Rev., 36, 1-2 (1999).
  • Cyclodextrins in Transdermal and Rectal Delivery.
    H Matsuda and H. Arima: Adv. Drug Deliv. Rev., 36, 81-99 (1999).
  • Cyclodextrins in Peptide and Protein Delivery.
    T. Irie and K. Uekama: Adv. Drug Deliv. Rev., 36, 101-123 (1999).
  • Cyclodextrin-Based Controlled Drug Release System.
    F. Hirayama and K. Uekama: Adv. Drug Deliv. Rev., 36, 125-141 (1999).
  • Cyclodextrin Drug Carrier Systems.
    K. Uekama, F. Hirayama and T. Irie: Chem. Rev., 98, 2045-2076 (1998).
  • Pharmaceutical Applications of Cyclodextrins III. Toxicological Issues and Safety Evaluation.
    T. Irie and K. Uekama: J. Pharm . Sci., 86, 147-162 (1997).
  • New Perspectives in Cyclodextrin Pharmaceutical Applications;Cyclodextrin Derivatives as New Drug Carriers.
    K. Uekama and T. Irie: Drug Invest., 2, 22-28 (1990).