[Representative Original Articles]

• Clinical Evaluation of Novel Natural Polysaccharides Sacran as a Skincare Material for Atopic Dermatitis Patients
  S. Fukushima, K. Motoyama, Y. Tanida, T. Higashi, Y. Ishitsuka, Y. Kondo, T. Irie, T. Tanaka, H. Ihn, H. Arima
  J. Cosm. Derm. Sci. Appl., , 6(1), 1-10 (2016).
  
• In Vitro and In Vivo Tumor-targeting siRNA Delivery Using Folate-PEG-appended Dendrimer (G4)/a-Cyclodextrin Conjugates
  A. Ohyama, T. Higashi, K. Motoyama, H. Arima
  Bioconjug. Chem., 27(3), 521-532 (2016).
  
• Thermoresponsive Formation of Dimethyl Cyclodextrin Polypseudorotaxanes and Subsequent One-pot Synthesis of Polyrotaxanes
  T. Higashi, L. Jun, X. Song, J. Zhu, M. Taniyoshi, F. Hirayama, D. Iohara, K. Motoyama, H. Arima
  
• ACS Macro Lett., 5(2), 158-162 (2016).
  Potential Use of Thioalkylated Mannose-modified Dendrimer (G3)/a-Cyclodextrin Conjugate as a NF-kB siRNA Carrier for the Treatment of Fulminant Hepatitis K. Motoyama, R. Mitsuyasu, C. Akao, I.I. Abu Hashim, N. Sato, T. Tanaka, T. Higashi, H. Arima
  
• Mol. Pharm., 12(9), 3129-3136 (2015).
  Potential use of fucose-appended dendrimer/a-cyclodextrin conjugates as NF-kB decoy carriers for the treatment of lipopolysaccharide-induced fulminant hepatitis in mice C. Akao, T. Tanaka, R. Onodera, A. Ohyama, N. Sato, K. Motoyama, T. Higashi, H. Arima
  
• J. Control. Release, in press (2014).
  Involvement of Autophagy in Antitumor Activity of Folate-appended Methyl-b-cyclodextrin . R. Onodera, K. Motoyama, N. Tanaka, A. Ohyama, A. Okamatsu, T. Higashi, R. Kariya, S. Okada, H. Arima
  Sci. Rep., 4(4417), 1-8 (2014).
  
• Design and evaluation of folate-appended a-, b- and g-cyclodextrins having a caproic acid as a tumor selective antitumor drug carrier in vitro and in vivo. A. Okamatsu, K. Motoyama, R. Onodera, T. Higashi, T. Koshigoe, Y. Shimada, K. Hattori, T. Takeuchi, H. Arima
  Biomacromolecules, 14(12), 4420-4428 (2013).
  
• Sugar-appended polyamidoamine dendrimer conjugates with cyclodextrins as cell-specific non-viral vectors H. Arima, K. Motoyama, T. Higashi
  Adv. Drug Deliv. Rev., 65(9), 1204-1214 (2013).
  
• Folate-appended b-cyclodextrin as a promising tumor targeting carrier for antitumor drugs in vitro and in vivo A. Okamatsu, K. Motoyama, R. Onodera, T. Higashi, T. Koshigoe, Y. Shimada, K. Hattori, T. Takeuchi, H. Arima
  Bioconjug. Chem., 24(4), 724-733 (2013).
  
• Potential Use of Folate-appended Methyl-b-Cyclodextrin as an Anticancer Agent R. Onodera, K. Motoyama, A. Okamatsu, T. Higashi, H. Arima
  Sci. Rep., 3, 1104, 1-9 (2013).
  
• Folate-PEG-appended Dendrimer Conjugate with a-Cyclodextrin as a Novel Cancer Cell-selective siRNA Delivery Carrier H. Arima, A. Yoshimatsu, H. Ikeda, A. Ohyama, K. Motoyama, T. Higashi, A. Tsuchiya, T. Niidome, Y. Katayama, K. Hattori, T. Takeuchi
  Mol. Pharm., 9(9), 2591-2604 (2012).
  
• Potential Use of Lactosylated Dendrimer (G3)/ a-cyclodextrin Conjugates as Hepatocyte-specific siRNA Carriers for the Treatment of Familial Amyloidotic Polyneuropathy Y. Hayashi, Y. Mori, S. Yamashita, K. Motoyama, T. Higashi, H. Jono, Y. Ando, H. Arima
  Mol. Pharm., 9(6), 1645-1653 (2012).
  
• In Vitro and In Vivo Gene Delivery Mediated by Lactosylated Dendrimer/a-Cyclodextrin Conjugates (G2) into Hepatocytes.
  H. Arima, S. Yamashita, Y. Mori, Y. Hayashi, K. Motoyama, K. Hattori, T. Takeuchi, H. Jono, Y. Ando, F. Hirayama, K. Uekama
  J. Control. Release, 146(1), 106-117 (2010).
  
• Design and evaluation of polypseudorotaxanes of pegylated insulin with cyclodextrins as sustained release system
  T. Higashi, F. Hirayama, S. Misumi, H. Arima, K. Uekama
  Biomaterial, 29, 3866-3871 (2008).
• Evaluation of polyamidoamine dendrimer/α-cyclodextrin conjugate (generation 3, G3) as a novel carrier for small interfering RNA (siRNA)
  T. Tsutsumi, F. Hirayama, K. Uekama, H. Arima
  J. Control. Release, 119, 349-359 (2007).
• Involvement of cholesterol in the inhibitory effect of dimethyl-β-cyclodextrin on P-glycoprotein and MRP2 function in Caco-2 cells.
  K. Yunomae, H. Arima, F. Hirayama and K. Uekama
  FEBS Lett., 536(1-3), 225-231 (2003). abstract
• Effect of Peracylation of β-Cyclodextrin on the Molecular Structure and on the Formation of Inclision Complexes: An X-Ray Study:
  M. Anibarro, K. Gessler, I. Uson, G. M. Sheldrick, K. Harata, K. Uekama, F. Hirayama, Y. Abe and W. Saenger:
  J. Am. Chem. Soc., 123, 11854-11862 (2001). abstract
• Contribution of P-Glycoprotein to the Enhancing Effects of Dimethyl-β-cyclodextrin on Oral Bioavailability of Tacrolimus.
  H. Arima, K. Yunomae, F. Hirayama and K. Uekama:
  J. Pharmacol. Exp. Ther., 297, 547 (2001). abstract
• Enhancement of Gene Expression by Polyamidoamine Dendrimer Conjugates with α-, β- and γ-Cyclodextrins.
  H. Arima, F. Kihara, F. Hirayama and K. Uekama:
  Bioconjugate Chem., 12, 476-484 (2001). abstract.
• Controlled Release of a Water-soluble Drug, Captopril, by a Combination of Hydrophilic and Hydrophobic Cyclodextrin Derivatives.
  Y. Ikeda, K. Kimura, F. Hirayama, H. Arima and K. Uekama:
  J. Control. Rel., 66, 271 (2000). abstract
• Solid-state ¹³C Nuclear Magnetic Resonance Spectroscopic Study on Amorphous Solid Complexes of Tolbutamide with 2-Hydroxypropyl-α- and -β-cyclodextrins.
  K. Kimura, F. Hirayama, H. Arima and K. Uekama:
  Pharm. Res., 16, 1729 (1999). abstract
• 6^A-O-{(4-Biphenylyl)-acetyl}-α-, -β-, and -γ-cyclodextrins and 6^A-Deoxy-6^A-amino-{(4-biphenylyl)-acetyl}-α-, -β- and -γ-cyclodextrins: Potential Prodrugs for Colon-Specific Delivery.
  K. Uekama, K. Minami and F. Hirayama: J. Med. Chem., 40, 2755 (1997). abstract

[Representative Review Articles]

• Recent Findings of PAMAM Dendrimer Conjugates with Cyclodextrins as Carriers of DNA and RNA
  H. Arima, K. Motoyama
  Sensors, 9, 6346-6361 (2009).
  
• Design and evaluation of cyclodextrin-based drug formulation.
  K. Uekama
  Chem. Pharm. Bull., 52(8), 900-915 (2004). abstract
• Recent Aspects of Cyclodextrin-based Pharmaceutical Formulations.
  H. Arima, F. Hirayama, C. T. Okamoto and K. Uekama:
  Recent Res. Devel. Chem. Pharm. Sciences, 2, 55-193 (2002). abstract
• Cyclodextrins in Peptide and Protein Delivery.
  T. Irie and K. Uekama:
  Adv. Drug Deliv. Rev., 36, 101 (1999).
• Cyclodextrin-Based Controlled Drug Release System.
  F. Hirayama and K. Uekama:
  Adv. Drug Deliv. Rev., 36, 125 (1999).
• Cyclodextrin Drug Carrier Systems.
  K. Uekama, F. Hirayama and T. Irie:
  Chem. Rev., 98, 2045 (1998).