教授国際学会発表・講演
- Teruko Imai: Metabolism of Prodrug and Antedrug/Soft drug, Jiangsu University (Jiangsu, China, December 9, 2015)
- Teruko Imai: Metabolism of Prodrug and Antedrug/Soft drug, Changzhou University (Changzhou, China, December 11, 2015)
- Takahiro Yonemitsu, Keiichirou Tanaka, Teruko Imai: Effect of intestinal hydrolysis of olmesartan medoxomil on its absorption, Globalization of Pharmaceutics Education Network 2014 (Helsinki, Finland, August 27–30, 2014)
- Keisuke Kurokawa, Keiichiro Tanaka, Teruko Imai: Transporter mediated permeation of p-amino benzoic acid on basal membrane in Caco-2 cell monolayer, Globalization of Pharmaceutics Education Network 2014 (Helsinki, Finland, August 27–30, 2014)
- Teruko Imai, Kayoko Ohura, Nicholas Bodor: Characteristics of Major Plasma Esterases, Butyrylcholinesterase and Paraoxonase and Practical Drug Design Based on Their Activity,11th France-Japan DDS symposium（Hyogo, October 5-8, 2014)
- Teruko Imai, Ahamd Samir, Yuta Yakushiji, Kayoko Ohura, Nicholas Bodor: Hydrolysis of two corticosteroids soft drugs by human plasma esterase, 19th North American ISSX Meeting / 29th JSSX Meeting（San Francisco, California, USA. October 19-23, 2014)
- Kayoko Ohura, Saori Sako, Keisuke Kurokawa, Yasuhisa Adachi, Shin-ichi Ninomiya, Teruko Imai: Establishment of Caco-2 subclone with the low carboxylesterase activity for evaluation of human intestinal absorption of prodrug, 19th North American ISSX Meeting / 29th JSSX Meeting（San Francisco, California, USA. October 19-23, 2014)
- Teruko Imai, Fatma Goksin Bahar, Kage Ayano, Kayoko Ohura, Nicholas Bodor: Hydrolysis of soft corticosteroid by plasma esterase (Orlando, Florida, May 12-15, 2013)
- Saori Sako, Keisuke Kurokawa, Kayoko Ohura, Shinsuke Aoyama, Yasuhisa Adachi,Shin-ichi Ninomiya, Teruko Imai: Establishment of Caco-2 subclone with the low carboxylesterase activity for evaluation of human intestinal absorption of prodrug,5th Asian Arden Conference （Nagoya, Japan, Aug 5-6, 2013)
- Masamichi Takase, Sou Tanoue, Seiya Fujihara, Kayoko Ohura, Teruko Imai: Expression of recombinant human carboxylesterase2 and its mutant in Sf9 in order to evaluate an importance of loop adjacent to active center, Asian Federation for pharmaceutical Sciences 2013 (Jeju Island, Korea, Nov 20-22, 2013)
- Takahiro Yonemitsu, Keiichiro Tanaka, Teruko Imai:Intestinal hydrolysis and absovability of olmesartan medoxomil in rat intestinal single-pass, Asian Federation for pharmaceutical Sciences 2013 (Jeju Island, Korea, Nov 20-22, 2013)
- Teruko Imai, Satomi Ariyoshi, Kayoko Ohura: Design of cutaneous fexofenadine prodrug using skin carboxylesterase activity, The Ninth China-Japan Joint Symposium on Drug Design and Development (Guilin, China , Sep 21-25, 2012)
- Teruko Imai: Cutaneous sustained release of fexofenadine, an anti-allergic agent, from its ester prodrug through hydrolase activity,10th France-Japan DDS symposium（Bordeaux, France, Oct 10-13, 2012)
- Fatma Goksin Bahar, Kayoko Ohura, and Teruko Imai: Characterization of plasma hydrolases and their species differences, Globalization of Pharmaceutics Education Network 2012 （Melbourne, Australia, November 28–December 1, 2012)
- Kayoko Ohura, Daisuke Iwamoto, Fatma Goksin Bahar, and Teruko Imai: Evaluation of synovial esterase for development of soft-drugs, Globalization of Pharmaceutics Education Network 2012 （Melbourne, Australia, November 28–December 1, 2012)
- Yuki Umemori, Masataka Nakashima, Daisuke Kadowaki, Ikuo Fujii and Teruko Imai:Pharmaceutical properties of molecular-targeting peptides "microantibody" against granulocyte colony-stimulating factor (G-CSF) receptor, Globalization of Pharmaceutics Education Network 2012 （Melbourne, Australia, November 28–December 1, 2012)
- Keiichiro Tanaka, Toshimitsu Soejima, Takaaki Nozawa, and Teruko Imai: Effect of conversion rate of active drug from prodrug on the subsequent bidirectional-transport in epithelial cell, Globalization of Pharmaceutics Education Network 2012 （Melbourne, Australia, November 28–December 1, 2012)
- Teruko Imai, Satomi Ariyoshi, Katsumi Tasaka, Kayoko Ohura: Distribution of carboxylesterase in rat skin and its effect on cutaneous absorption of fexofenadine prodrug, 8th Retrometabolism Based Drug Design and Targeting Conference (Graz, Austria, June 2-4, 2011)
- Ayano Kage, Kayoko Ohura, Teruko Imai: Involvement of carboxylesterase in the hydrolysis of ester derivatives of various steroid compounds, Asian Federation for pharmaceutical Sciences 2011 (Kuaka Lumpur, Malaysia, December 9-12, 2011)
- Keiichirou Tanaka, Toshimitsu Soejima, Takaaki Nozawa, Teruko Imai: Prediction of in vivo intestinal hydrolysis and absorption of prodrug from in vitro data, Asian Federation for pharmaceutical Sciences 2011 (Kuaka Lumpur, Malaysia, December 9-12, 2011)
- Sou Tanoue, Kouske Tanaka, Seiya Fujihara, Kayoko Ohura, Teruko Imai: Elucidation of catalytic property and structural feature of human carboxylesterases2, Asian Federation for pharmaceutical Sciences 2011 (Kuaka Lumpur, Malaysia, December 9-12, 2011)
- Kayoko Ohura, Teruko Imai: Evaluation of P-glycoprotein-mediated transport of ester prodrugs and the expression of esterases in LLC-GA5-COL300 cells, Asian Federation for pharmaceutical Sciences 2011 (Kuaka Lumpur, Malaysia, December 9-12, 2011)
- Fatma Goksin Bahar, Kayoko Ohura, Yasuhiro Uno, Teruko Imai: Hydrolysis property analysis of human and cynomolgus monkey plasma butyryl-cholinesterase, International Symposium of Past, Present and Future of Molecular Pharmacokinetics; Integration of Basic Science, Drug Development and Regulation (PPF Symposium) (Tokyo, Japan, January 16-18, 2012)
- Kayoko Ohura, Teruko Imai: Evaluation of P-glycoprotein-mediated transport of ester prodrugs and the expression of esterases in LLC-GA5-COL300 cells, International Symposium of Past, Present and Future of Molecular Pharmacokinetics; Integration of Basic Science, Drug Development and Regulation (PPF Symposium) (Tokyo, Japan, January 16-18, 2012)
- Teruko Imai, Kayoko Ohura: Prediction of in vivo intestinal hydrolysis and absorption of prodrug from in vitro data, 9th France-Japan Drug Delivery System symposium (Kumamoto, Japan, September 26-29, 2010)
- Satomi Ariyoshi, Katsumi Tasaka, Kayoko Ohura, Teruko Imai: Cutaneous disposition of fexofenadine prodrug controlled by carboxylesterase in rat, Globalization of Pharmaceutics Education Network (North Carolina, USA, November 10–12, 2010)
- Satomi Ariyoshi, Katsumi Tasaka, Kayoko Ohura, Teruko Imai: Rat skin permeability of fexofenadine prodrug and its cutaneous hydrolysis, FIP Pharmaceutical Sciences World Congress 2010 in association with AAPS Annual Meeting & Exposition (Louisiana, USA, November 14–18, 2010)
- Teruko Imai: Carboxylesterases: Targets for drug and prodrug efficacy and pharmacokinetics, FIP Pharmaceutical Sciences World Congress 2010 in association with AAPS Annual Meeting & Exposition (Louisiana, USA, November 14–18, 2010)
- Teruko Imai: Species differences of carboxylesterase involved in bioconversion of ester-based prodrug, 7th Retrometabolism Based Drug Design and Targeting Conference (Florida, USA, May 10-13, Invitation Lecture)
- Kayoko Ohura, Katsumi Tasaka, Chie Okayama, Shotaro Uehara, Yasuhiro Uno, Teruko Imai: Cloning of monkey intestinal carboxylestrease and evaluation of its esterase an activity in stably-transfected HEK293 cells, Asian Federation for pharmaceutical Sciences 2009 (Fukuoka, Japan, October 15-17)
- Takaaki Nozawa, Kouichi Murakami, Teruko Imai: In situ and in vitro evaluation of intestinal absorption of temocapril, Asian Federation for pharmaceutical Sciences 2009 (Fukuoka, Japan, October 15-17)
- Masumi Imoto, Hikaru Nishiyama, Chiori Tsunawaki, Kayoko Ohura, Ikumi Tamai, Teruko Imai: Evaluation of prodrug absorption by Caco-2 cells and new subclones, Asian Federation for pharmaceutical Sciences 2009 (Fukuoka, Japan, October 15-17)
- Takaaki Nozawa, Teruko Imai: Modification of intestinal absorption of temocapril by bioconversion mediated by carboxylesterase, Globalization of Pharmaceutics Education Network (Leuven, Kingdom of Belgium, September 9-12, 2008)
- Kayoko Ohura, Teruko Imai: Prodrug design to improve the oral absorption of fexofenadine, Globalization of Pharmaceutics Education Network (Leuven, Kingdom of Belgium, September 9-12, 2008)
- Teruko Imai: Species differences of carboxylesterase involved in bioconversion of ester-based prodrug, 8th France-Japan Drug Delivery System symposium (Cannes, France, October 5-8, 2008)
- Teruko Imai: The role of carboxylesterase in the rat intestinal absorption of ester-containing drugs and aging on intestinal esterase activitys, 6th Retrometabolism Based Drug Design and Targeting Conference (Budapest, Hungary, June 5-7, 2007, Invitation Lecture)
- Teruko Imai: Rational prodrug design based on carboxylesterase activity, Thailand Annual Research Meeting (Bangkok, Kingdom of Thailand, December 12, 2007, Invitation Lecture)
- Imai T.: Prodrug design based on substrate specificity of carboxylesteraase isozyme, 7th France-Japan Drug Delivery System symposium (Shiga, Japan, September 24-27, 2006, Invitation Lecture)
- Teruko Imai, Mayumi Shii, Kayoko Ohura, Mitsuru Hashimoto: Rational Design of fexofenadin prodrug, 5th Retrometabolism Based Drug Design and Targeting Conference (Hakone, Japan, May 8-11, 2005)
- Kenji Masaki, Mitsuru Hashimoto, Teruko Imai: The role of carboxylesterase in the rat intestinal absorption of drug and the effect of aging on intestinal esterase activity, 13thNA ISSX Meeting 20th JSSX Meeting (Maui, Hawaii, USA, October 23-27, 2005)
- Yuko Takase, Toshiharu Tanaka, Mitsuru Hashimoto, Teruko Imai: Involvement of carboxylesterase in hydrolysis of drug during permeation across rat skin, 13thNA ISSX Meeting 20th JSSX Meeting (Maui, Hawaii, USA, October 23-27, 2005)
- Kenji Masaki , Megumi Taketani, Teruko Imai: Effect of a Mucosal Hydrolase Activity on the Intestinal Absorption of an Ester-type Prodrug, Globalization of Pharmaceutics Education Network (Kyoto, Japan, May 26-28, 2004)
- Kayoko Ohura, Masumi Imoto, Hiromi Nishi, Masakiyo Hosokawa, Kan Chiba, Teruko Imai: Synergistic Function of Carboxylesterase and Transporter in the Membrane Transport of Ester-Type prodrugs, Globalization of Pharmaceutics Education Network (Kyoto, Japan, May 26-28, 2004)
- Mayumi Shii, Megumi Taketani, Mitsuru Hashimoto, Masakiyo Hosokawa, Kan Chiba, Teruko Imai: Difference of Substrate Specificity among Carboxylesterase Isozyme, Globalization of Pharmaceutics Education Network (Kyoto, Japan, May 26-28, 2004)
- Teruko Imai, Mayumi Shii, Megumi Taketani, Mitsuru Hashimoto, Masakiyo Hosokawa, Kan Chiba: Differences of substrate specificity among carboxylesterase isozymes, Pharmaceutical Sciences World Congress (Kyoto, Japan, May 30-6.3, 2004 (Sponcered by International Pharmaceutical Federation)
- Masumi Imoto, Mitsuru Hashimoto, Ikuo Yamamoto, Teruko Imai: Precision of intestinal permeability of ester prodrug predicted in Caco-2 cell monolayer, Pharmaceutical Sciences World Congress (Kyoto, Japan, May 30-6.3, 2004)
- Kenji Masaki, Megumi Taketani, Teruko Imai: Effect of a Mucosal Hydrolase Activity on the Intestinal Absorption of an Ester-type Prodrug, Pharmaceutical Sciences World Congress (Kyoto, Japan, May 30-6.3, 2004)
- Teruko Imai, Yasushi Yoshigae, Megumi Taketani, Asami Imatsuji, Mitsuru Hashimoto: Activation of Prodrug by Carboxylesterase Isozymes, 4th Retrometabolism Based Drug Design and Targeting Conference (Florida, USA, May 11-14, 2003) (Invitation Lecture)
- Teruko Imai, Megumi Taketani, Kayoko Ohura, Hiromi Ashikari, Mayumi Shii, Masakiyo Hosokawa, Kan Chiba: Role of Carboxylesterase and Efflux Transporters in the Absorption of Drugs in the Intestine, Molecular Biopharmaceutics (Hawaii, USA, January 22-24, 2003)
- Toshiharu Tanaka, Harunobu Iwase, Teruko Imai: Identification and the Substrate Specificity of Carboxyleserase in Rat Skin, Molecular Biopharmaceutics (Hawaii, USA, January 22-24, 2003)
- Teruko Imai, Kayoko Ohura, Hiromi Ashikari, Masakiyo Hosokawa, Kan Chiba: Role of Carboxylesterase and Efflux Transporters in the Trasnport of Drugs in the Brain, Todai International Symposium: Drug derivery to the central nervous system (Tokyo, Japan, January 29-31, 2003)
- Teruko Imai, Megumi Taketani, Masakiyo Hosokawa and Kan Chiba: Rational Design of Prdrugs Based on the Organ-Specific Esterase Activity, 3rd Retrometabolism Based Drug Design and Targeting Conference (Florida, USA, May 13-16, 2001) (Invitation Lecture)
- Taketani M., Hosokawa M., Chiba K., Imai T.: SpeciesDifferences in Carboxyleterase Activities of Liver and Small Intestine, World Congress of Pharmacy and Pharmaceutical Sciences 2001 (61st International Congress of FIP, Singapore, September 1-6, 2001)
- Imai T., Ohtsu M, Ohashi K., Nito S.: Cytochrome P450 Enzymes Are Responsible for the Hydrolysis of NO-1886, A Lipoprotein Lopase Activity Promoting Drug That Inhibits Esterase Activity, World Congress of Pharmacy and Pharmaceutical Sciences 2001 (61st International Congress of FIP, Singapore, September 1-6, 2001)
- K. Matsumoto, T. Imai, and M. Otagiri, In vitro and in vivo evaluation of the enhancing activity of bile acid on the intestinal absorption Millennial World Congress of Pharmaceutical Sciences (San Francisco, Apr., 2000)
- J-S. Zhang, T. Imai, and M. Otagiri, Effects of cisplatin-chondroitin sulfate A complex on reducing the nephrotoxicity of cisplatin Millennial World Congress of Pharmaceutical Sciences (San Francisco, Apr., 2000)
- T. Imai ., A. Horita, and M. Otagiri, Prodrug activation via catalytic antibodies Millennial World Congress of Pharmaceutical Sciences (San Francisco, Apr., 2000)
- T. Imai , M. Taketani, M. Otagiri, M. Hosokawa, and K. Chiba Rational design of prodrugs based on the organ specific esterase activity Globalization of Pharmaceutics Education Network (Uppsala, Sep., 2000)
- T. Imai, , K. Matsumoto, M. Sakai, H. Ohtake, H. Azuma, and M. Otagiri, Mechanism of enhancing activity of glycyrrhizin on the intestinal absorption of drugs Strategies for Optimizing Oral Drug Delivery: Scientific to Regulatory Approaches (Kobe, Apr., 1999)
- T. Imai, M. Taketani, T. Suzu, K. Kusube, and M. Otagiri, Identification of P450 enzymes involved in azelastine metabolism and prediction of azelastine-drug interaction International conference on drug interaction (Hamamatsu, Oct., 1999)