- Design and evaluation of lactose-modified cyclodextrin for the potential treatment of Niemann-Pick Type C Disease
R. Onaga, T. Nishida, R. Yokoyama, R. Onodera, T. Higashi, T. Takeo, N. Nakagata, Y. Ishitsuka, Y. Kondo, T. Irie, K. Motoyama
9th Asian Conference on Coordination Chemistry, Bangkok, Thailand, February 19-22 (2024).
- Multistep transformable polyrotaxanes-based versatile delivery platform of nucleic acid drugs, mRNA, protein drugs, and genome-editing ribonucleoproteins
T. Taharabaru, K. Motoyama, T. Higashi
9th Asian Conference on Coordination Chemistry, Bangkok, Thailand, February 19-22 (2024).
- Transformable supramolecular material for reversible PEGylation of protein drugs
K. Utatsu, T. Kogo, T. Taharabaru, R. Onodera, K. Motoyama, T. Higashi
9th Asian Conference on Coordination Chemistry, Bangkok, Thailand, February 19-22 (2024).
- Fabrication of polycatenanes via condensation of two polypseudorotaxanes for drug delivery carrier
T. Higashi, T. Taharabaru, K. Motoyama
9th Asian Conference on Coordination Chemistry, Bangkok, Thailand, February 19-22 (2024).
- Advanced Application of Cyclodextrins for Pharmaceutical Sciences
K. Motoyama
Asian Federation for Pharmaceutical Sciences (AFPS) Conference, Hanoi, Vietnam, November 8-10 (2023).
- Polyrotaxanes-based multistep transformable polymers for delivery platform of nucleic acid drugs, mRNA, protein drugs, and genome-editing ribonucleoproteins
T.Taharabaru, K. Motoyama, T. Higashi
Asian Federation for Pharmaceutical Sciences (AFPS) Conference, Hanoi, Vietnam, November 8-10 (2023).
- Design and Evaluation of shRNA Polyplex with Cyclodextrin-modified Dendrimer for Treatment of Systemic and Localized Amyloidosis
Masamichi Inoue, Takashi Saito, Takaomi C. Saido, Risako Onodera, Taishi Higashi, Keiichi Motoyama, Hirofumi Jono
The 18th International Symposium on Amyloidosis (online), Heidelberg, Germany, September 4-8 (2022).
- Feasibility Study of Cationic Dendrimer-based Polyplex as a Multi-functional Drug for Alzheimer's Disease
Masamichi Inoue, Takashi Saito, Takaomi C. Saido, Risako Onodera, Taishi Higashi, Keiichi Motoyama, Hirofumi Jono
The 3rd International Conference on Advanced Materials and Nanotechnology, Singapore, August 18-19 (2022).
- Dual-targeting for Colon Cancer Cells and Tumor-Associated Macrophages by Mannose- modified Methyl-β-Cyclodextrins as Antitumor Therapeutic Agents
Yoshitaka Ohno, Maiko Toshino, Yukio Fujiwara, Yoshihiro Komohara, Risako Onodera, Taishi Higashi, Keiichi Motoyama
The 3rd International Conference on Advanced Materials and Nanotechnology, Singapore, August 18-19 (2022).
- Feasibility Study of shRNA Polyplex as a Multi-functional Drug for Alzheimer's Disease
Masamichi Inoue, Hirofumi Jono, Takashi Saito, Risako Onodera, Taishi Higashi, Keiichi Motoyama
JSB/SFB Joint Symposium (online), Hawaii, USA, January 8-10 (2022).
- Transformable Supramolecular Materials for Reversible PEGylation of Protein Drugs
Kosei Utatsu, Tetsuya Kogo, Toru Taharabaru, Risako Onodera, Keiichi Motoyama, Taishi Higashi
JSB/SFB Joint Symposium (online), Hawaii, USA, January 8-10 (2022).
- Cationic Dendrimer as a Novel Melanogenesis Inhibitor
Takaya Ariyoshi, Masamichi Inoue, Risako Onodera, Taishi Higashi, Keiichi Motoyama
JSB/SFB Joint Symposium (online), Hawaii, USA, January 8-10 (2022).
- Multi-step Transformable Supermolecules for Delivery of the Genome Editing Molecule
Toru Taharabaru, Takuya kihara, Risako Onodera, Keiichi Motoyama, Taishi Higashi
APSTJ Global Education Seminar 2021-2nd, Online (Zoom), December 2 (2021).
- Mitophagy-mediated Antitumor Activity Induced by Folate-appended Methyl-β-cyclodextrin
Keiichi Motoyama, Nao Tanaka, Yuki Yamashita, Risako Onodera, Taishi Higashi, Hidetoshi Arima
The 3rd Workshop for Japan-Korea Young Scientists on Pharmaceutics, Chiba, Japan, July 10-11 (2019).
- Fasting Suppresses IL-33-mediated Eosinophilic Lung Inflammation
Yusuke Suzuki, Tomoya Hayashi, Risako Onodera, Taishi Higashi, Keiichi Motoyama
The 3rd Workshop for Japan-Korea Young Scientists on Pharmaceutics, Chiba, Japan, July 10-11 (2019).
- Evaluation of Lactose-appended Hydroxypropyl-β-cyclodextrin as a Drug Carrier for Brain
Ryoma Yokoyama, Risako Onodera, Taishi Higashi, Keiichi Motoyama
The 3rd Workshop for Japan-Korea Young Scientists on Pharmaceutics, Chiba, Japan, July 10-11 (2019).
- shRNA Complex with Cyclodextrin/Dendrimer Conjugate for Treatment of Hereditary Amyloidogenic Transthyretin Amyloidosis
Masamichi Inoue, Hirofumi Jono, Taishi Higashi, Yukio Ando, Risako Onodera, Hidetoshi Arima, Keiichi Motoyama
The 6th Global Conference on Polymer and Composite Materials (PCM), Bangkok, Thailand July 8-11 (2019).
- One-pot Synthesis of Cyclodextrin-based Polycatenanes as Novel Supermolecules
Kentaro Morita, Keiichi Motoyama, Jun Li, Taishi Higashi
The 6th Global Conference on Polymer and Composite Materials (PCM), Bangkok, Thailand July 8-11 (2019).
- Folate-modified cyclodextrin improved the active tumor accumulation of BSH and showed a strong therapeutic effect of BNCT
Yoshitaka Matsumoto, Kenjiro Hattori, Hidetoshi Arima, Keiichi Motoyama, Taishi Higashi, Nobuyoshi Fukumitsu, Teruhito Aihara, Hitoshi Ishikawa, Kei Nakai, Hiroaki Kumada and Hidetoshi Sakurai
58th Annual Conference of the Particle Therapy Co-Operative Group (PTCOG58), Manchester, UK, June 10-15 (2019).
- Induction of Mitophagy-mediated Antitumor Activity with Folate-appended Methyl-β-cyclodextrin
Keiichi Motoyama, Risako Onodera, Taishi Higashi
4th Symposium on Weak Molecular Interactions, Matsue, Japan, May 17-19 (2019).
- Antitumor Activity of Macromolecular Polysaccharide Sacran in Ovarian Cancer
Yoshitaka Ohno, Kotaro Makisaka, Yukio Fujiwara, Yoshihiro Komohara, Risako Onodera, Taishi Higashi, Keiichi Motoyama
APSTJ global education (GE) seminar, Nagasaki, Japan, March 7 (2019).
- Enhanced protective effect of influenza split vaccination by the combination of DAMP-inducing and PAMP adjuvants
Tomoya Hayashi, Masatoshi Momota, Takato Kusakabe, Etsushi Kuroda, Ken Ishii and Hidetoshi Arima
International Society for Vaccine (ISV) Asia meeting, Hwasun, South Korea, November 16 (2018).
- Supramolecular Sustained Release System of Insulin Utilizing the Self-assembly PEGylation and Polypseudorotaxane Formation
Taishi Higashi, Tatsunori Hirotsu, Risako Onodera, Keiichi Motoyama, Hidetoshi Arima
18th Symposium for Gene・Design and Delivery, Kitakyushu, Japan, July 28 (2018).
- Combination of 2-Hydroxypropyl-β-Cyclodextrin and CpG-ODN as influenza split vaccine adjuvant
Tomoya Hayashi, Takato Kusakabe, Masatoshi Momota, Shingo Kobari, Etsushi Kuroda, Taishi Higashi, Keiichi Motoyama, Ken Ishii and Hidetoshi Arima
The 25th International Symposium on Molecular Cell biology of Macrophages (MMCB2018), Osaka, Japan, June 19-20 (2018).
- Mitophagy-mediated Tumor Cell Death Caused by Folate-appended Methyl-β-cyclodextrin
Keiichi Motoyama, Yuki Yamashita, Taishi Higashi, Hidetoshi Arima
ACHEMA- World Forum and Leading Show for the Process Industries (ACHEMA 2018), Frankfurt, Germany, June 11-15 (2018).
- Cyclodextrins as drug targeting vehicles and active pharmaceutical ingredients (invited lecture)
H. Arima, K. Motoyama, T. Higashi
The 19th International Cyclodextrin Symposium, Tokyo, Japan, April 29 (2018).
- Involvement of mitophagy-mediated cell death for antitumor activity of folate-appended methyl-β-cyclodextrin (invited lecture)
K. Motoyama, Y. Yamashita, N. Tanaka, T. Higashi, H. Arima
The 19th International Cyclodextrin Symposium, Tokyo, Japan, April 29 (2018).
- Induction of RNAi Using a siRNA Complex with Folate-PEG-appended Polyamidoamine Dendrimer (G3) Conjugates with Glucuronylglucosyl-β-cyclodextrin as Novel Tumor Cell Targeted siRNA Carriers
A. Mohammed, A. Ohyama, T. Higashi, K. Motoyama, H. Arima
The 19th International Cyclodextrin Symposium, Tokyo, Japan, April 28-29 (2018).
- Cooperative Immunostimulation by Combined Adjuvants of 2-Hydroxypropyl-β-Cyclodextrin and CpG-ODN
T. Hayashi, K. Motoyama, T. Higashi, K. Ishii, H. Arima
The 19th International Cyclodextrin Symposium, Tokyo, Japan, April 28-29 (2018).
- Evaluation of Lactose-appended β-Cyclodextrin as a Novel Therapeutic Agent for Niemann-Pick Type C Disease
Y. Maeda, R. Nishiyama, K. Motoyama, T. Higashi, Y. Yamada, Y. Ishitsuka, Y. Kondo, T. Irie, T. Era, H. Arima
The 19th International Cyclodextrin Symposium, Tokyo, Japan, April 28-29 (2018).
- One-pot Synthesis and Facile Isolation of Cyclodextrin-based Polycatenanes
K. Morita, T. Higashi, X. SONG, J. ZHU, J. LI, A. Tamura, N. Yui, K. Motoyama, H. Arima
The 19th International Cyclodextrin Symposium, Tokyo, Japan, April 28-29 (2018).
- Design and Evaluation of shRNA Complex with Cyclodextrin/Dendrimer Conjugate for Treatment of Transthyretin Amyloidosis
M. Inoue, H. Jono, T. Higashi, K. Motoyama, Y. Ando, H. Arima
The 17th International Symposium on Amyloidosis, Kumamoto, Japan, March 26-29 (2018).
- Potential application of dendrimer/cyclodextrin conjugates with targeting ligands as novel carriers for oligonucleotide drugs
H. Arima, K. Motoyama, T. Higashi
KEY Forum 2018: The 3rd International Symposium on Stem Cell Traits and Developmental Systems, Kumamoto, Japan, January 11-12 (2018).
- Enhancement of Curcumin Wound Healing Ability by Complexation with 2-Hydroxypropyl-γ-cyclodextrin in Sacran Hydrogel Film
K. Motoyama, N. Wathoni, T. Higashi, H. Arima
KEY Forum 2018: The 3rd International Symposium on Stem Cell Traits and Developmental Systems, Kumamoto, Japan, January 11-12 (2018).
- Cyclodextrin-based Supramolecular Hydrogels as Pharmaceutical Materials for Protein Drugs
T. Higashi, K. Motoyama, H. Arima
KEY Forum 2018: The 3rd International Symposium on Stem Cell Traits and Developmental Systems, Kumamoto, Japan, January 11-12 (2018).
- Evaluation of lactose-appended β-cyclodextrin as a novel therapeutic agent for hepatosplenomegaly of Niemann-Pick Type C diseaseY.Maeda, R. Nishiyama, K. Motoyama, T. Higashi, Y. Yamada, Y. Ishitsuka, Y. Kondo, T. Irie, T. Era, H. Arima
KEY Forum 2018: The 3rd International Symposium on Stem Cell Traits and Developmental Systems, Kumamoto, Japan, January 11-12 (2018).
- Efficient Anticancer Drug Delivery for Pancreatic Cancer Utilizing Reversible PEGylated Bromelain
T. Kogo, T. Hirotsu, N. Sato, T. Higashi, K. Motoyama, H. Arima
9th Asian Cyclodextrin Conference (9ACC) 2017, Singapore, December 14-17 (2017)
- Folate-appended β-Cyclodextrin as a Promising Tumor Targeting Carrier for Antitumor Drugs
Y. Yamashita, A. Okamatsu, T. Hirotsu, K. Hattori, K. Motoyama, T. Higashi, H. Arima
9th Asian Cyclodextrin Conference (9ACC) 2017, Singapore, December 14-17 (2017)
- One-pot Synthesis of Polycatenanes Containing Cyclodextrins
K. Morita, T. Higashi, X. Song, J. Zhu, J. Li, A. Tamura, N. Yui, K. Motoyama, H. Arima
9th Asian Cyclodextrin Conference (9ACC) 2017, Singapore, December 14-17 (2017)
- Synergistic Adjuvant Effect of Combination of 2-Hydroxypropyl-β-Cyclodextrin and CpG-ODN
T. Hayashi, K. Motoyama, T. Higashi, K. Ishii. H. Arima
9th Asian Cyclodextrin Conference (9ACC) 2017, Singapore, December 14-17 (2017)
- Preparation and Evaluation of Folate PEG-appended Polyamidoamine Dendrimer (G3) Conjugates with Glucuronylglucosyl-β-cyclodextrin as Novel Tumor Cell-selective siRNA Carriers
A. Mohammed, A. Ohyama, T. Higashi, K. Motoyama, H. Arima
9th Asian Cyclodextrin Conference (9ACC) 2017, Singapore, December 14-17 (2017)
- Sustained and Controllable Release System of Insulin Utilizing the Combination Technology of Self-assembly PEGylation and Polypseudorotaxane Formation
T. Higashi, T. Hirotsu, K. Motoyama, H. Arima
9th Asian Cyclodextrin Conference (9ACC) 2017, Singapore, December 14-17 (2017)
- The Use of Cyclodextrins as Drug Delivery Carriers and Active Pharmaceutical Ingredients
H. Arima, K. Motoyama, T. Higashi
9th Asian Cyclodextrin Conference (9ACC) 2017, Singapore, December 14-17 (2017)
- Mitophagy-mediated Novel Cell Death Induced by Folate-appended Methyl-β-cyclodextrin
K. Motoyama, Y. Yamashita, T. Higashi, H. Arima
Drug Discovery & Therapy World Congress 2017, Boston, USA, July 10-13 (2017)
- Ameliorating Effects of Methylated-Cyclodextrins on GM1-ganglioside Accumulation in Cells Derived from GM1-gangliosidosis
Y. Maeda, K. Motoyama, T. Higashi, T. Takeo, N. Nakagata, Y. Kurauchi, H. Katsuki, Y. Kondo, Y. Ishitsuka, T. Irie, T. Era, H. Arima
19th European Carbohydrate Symposium, Barcelona, Spain, July 2-6 (2017)
- Induction of Mitophagy-mediated Antitumor Activity with Folate-appended Methyl-β-cyclodextrin
K. Motoyama, N. Tanaka, Y. Yamashita, T. Higashi, H. Arima
6th FIP Pharmaceutical Sciences World Congress 2017, Stockholm, Sweden, May 21-24 (2017)
- Potential Use of Cyclodextrins as Drug Carriers and Active Pharmaceutical Ingredients
H. Arima
Kumamoto Symposium on Therapeutic/Diagnosis Techniques and Medical Devices, Kumamoto, Japan, March 15 (2017)
- Potential use of cyclodextrins as drug carriers and active pharmaceutical ingredients for cancer treatments
H. Arima, K. Motoyama, T. Higashi
International Symposium on Drug Delivery and Pharmaceutical Sciences (ISDDPS), Kyoto, Japan, March 9-10 (2017)
- One-pot Synthesis of Polyrotaxanes with DM-CyD through Their Self-association in Water at High Temperature
S. Egashira, K. Morita, T. Higashi, J. Li, X. Song, J. Zhu, K. Motoyama, H. Arima
The 11th SPSJ International Polymer Conference (IPC2016), Fukuoka, Japan, December 13-16 (2016)
- Tumor Selective and Safety Supplemental Therapy of Tumor Suppressor microRNA Using Folate PEG-appended Dendrimer (G4) Conjugate with α-Cyclodextrin
Y. Otosu, A. Ohyama, T. Higashi, K. Motoyama, H. Arima
The 11th SPSJ International Polymer Conference (IPC2016), Fukuoka, Japan, December 13-16 (2016)
- Effects of Methylated Cyclodextrins on GM1-ganglioside Level in both Fibroblasts drived from a GM1-gangliosidosis Patient and Brains of GM1-gangliosidosis Model Mice
Y. Maeda, K. Motoyama, T. Higashi, Y. Horikoshi, T. Takeo, N. Nakagata, Y. Kurauchi, H. Katsuki, Y. Kondo, Y. Ishitsuka, T. Irie, T. Era, H. Arima
18th International Cyclodextrin Symposium, Gainesville, U.S.A, May 18-21 (2016)
- Evaluation of Polyamidoamine Dendrimer (G3) Conjugates with Glucuronylglucosyl-β-cyclodextrin as siRNA Carriers
A.F. Abdelwahab Mohammed, A. Ohyama, T. Higashi, K. Motoyama, H. Arima
18th International Cyclodextrin Symposium, Gainesville, U.S.A, May 18-21 (2016)
- Cancer Treatment Utilizing Tumor-targeting Nucleic Acid Drugs Delivery by Folate-PEG-appended Dendrimer (G4) Conjugate with α-Cyclodextrin
A. Ohyama, Y. Otosu, T. Higashi, K. Motoyama, H. Arima
18th International Cyclodextrin Symposium, Gainesville, U.S.A, May 18-21 (2016)
- Design and Evaluation of Self-assembly PEGylation Retaining Activity of Protein Drugs Based on Supramolecular Complexation with Cyclodextrins
H. Arima, T. Hirotsu, T. Higashi, I.I. Abu Hashim, K. Motoyama, K. Wada
18th International Cyclodextrin Symposium, Gainesville, U.S.A, May 18-21 (2016)
- Stabilization and sustained release of protein drugs utilizing cyclodextrin supramolecular hydrogels
T. Higashi, K. Motoyama, H. Arima
EMN Meeting On Hydrogel Materials 2016, Singapore, May 9-13 (2016)
- Effects of cyclodextrins on function of various transporters in vinblastine-resistant Caco-2 cell monolayers
H. Arima, K. Yunomae, T. Morikawa, Y. Yamasaki, K. Motoyama, T. Higashi
Asian Federation for Pharmaceutical Sciences (AFPS) Conference, Bangkok, Thailand, November 25-27 (2015)
- Fucose-appended dendrimer/α-cyclodextrin conjugate as a novel NF-κB decoy carrier to Kupffer cells in fulminant hepatitis mice induced by lipopolysaccharide
K. Motoyama, C. Akao, R. Mitsuyasu, T. Higashi, H. Arima
Asian Federation for Pharmaceutical Sciences (AFPS) Conference, Bangkok, Thailand, November 25-27 (2015)
- Combinations of cyclodextrins and polyamidoamine dendrimer as a novel refolding system for protein
T. Higashi, K. Arima, K. Motoyama, H. Arima
Asian Federation for Pharmaceutical Sciences (AFPS) Conference, Bangkok, Thailand, November 25-27 (2015)
- Evaluation of dendrimer conjugate with glucuronylglucosyl-β-cyclodextrin for treatment of transthyretin-related familial amyloidotic polyneuropathy
Y. Yamashita, K. Fujisawa, M. Inoue, T. Anno, T. Higashi, K. Motoyama, H. Jono, Y. Ando, H. Arima
Asian Federation for Pharmaceutical Sciences (AFPS) Conference, Bangkok, Thailand, November 25-27 (2015)
- Supplemental therapy of tumor suppressor microRNA using folate-PEG-appended dendrimer (G4) conjugate with α-cyclodextrin
Y. Otosu, A. Ohyama, T. Higashi, K. Motoyama, H. Arima
Asian Federation for Pharmaceutical Sciences (AFPS) Conference, Bangkok, Thailand, November 25-27 (2015)
- Antitumor activity of folate-appended methyl-β-cyclodextrin in mice xenografted human solid tumor cells
Y. Yamashita, N. Tanaka, R. Onodera, K. Motoyama, T. Higashi, H. Arima
Asian Federation for Pharmaceutical Sciences (AFPS) Conference, Bangkok, Thailand, November 25-27 (2015)
- Pharmaceutical properties of insulin conjugate with glucuronylglucosyl-β-cyclodextrin
M. Sugio, T. Hirotsu, T. Higashi, K. Motoyama, F. Hirayama, K. Uekama, H. Arima
Asian Federation for Pharmaceutical Sciences (AFPS) Conference, Bangkok, Thailand, November 25-27 (2015)
- One-pot synthesis of dimethyl cyclodextrin polyrotaxanes through thermoresponsive formation of polypseudorotaxanes
S. Egashira, T. Higashi, J. Li, X. Song, J. Zhu, M. Taniyoshi, F. Hirayama, K. Motoyama, H. Arima
Asian Federation for Pharmaceutical Sciences (AFPS) Conference, Bangkok, Thailand, November 25-27 (2015)
- Improvement of physicochemical stability of highly-concentrated Antibodies using cyclodextrin polypseudorotaxane hydrogels
N. Ohshita, A. Tajima, T. Higashi, K. Motoyama, S. Koyama, R. Iibuchi, S. Mieda, K. Handa, H. Arima
Asian Federation for Pharmaceutical Sciences (AFPS) Conference, Bangkok, Thailand, November 25-27 (2015)
- Amelioration of unesterified cholesterol accumulation by multi-lactose appended β-cyclodextrin in NPC-like HepG2 cells
R. Nishiyama, Y. Hirai, K. Motoyama, T. Higashi, Y. Ishitsuka, Y. Kondo, T. Irie, T. Era, H. Arima
Asian Federation for Pharmaceutical Sciences (AFPS) Conference, Bangkok, Thailand, November 25-27 (2015)
- Antiulcerative effect of sacran on indomethacin-induced gastric ulcer in mice
T. Hayashi, Y. Abe, S. Kaneko, T. Otsuka, K. Sato, Y. Ishitsuka, Y. Kondo, T. Irie, T. Higashi, K. Motoyama, H. Arima
Asian Federation for Pharmaceutical Sciences (AFPS) Conference, Bangkok, Thailand, November 25-27 (2015)
- Feasibility study of cyclodextrins as active pharmaceutical ingredients for the treatment of GM1-gangliosidosis
Y. Maeda, K. Motoyama, T. Higashi, Y. Horikoshi, T. Takeo, N. Nakagata, Y. Kurauchi, H. Katsuki, Y. Kondo, Y. Ishitsuka, T. Irie, T. Era, H. Arima
Asian Federation for Pharmaceutical Sciences (AFPS) Conference, Bangkok, Thailand, November 25-27 (2015)
- Self-assembly PEGylation retaining activity of protein drugs via supramolecular complexation with cyclodextrins
T. Hirotsu, T. Higashi, I.I. Abu Hashim, K. Motoyama, K. Wada, H. Arima
Asian Federation for Pharmaceutical Sciences (AFPS) Conference, Bangkok, Thailand, November 25-27 (2015)
- Tumor-targeting siRNA delivery utilizing of folate-PEG appended dendrimer (G4) conjugate with α-cyclodextrin
A. Ohyama, T. Higashi, K. Motoyama, H. Arima
Asian Federation for Pharmaceutical Sciences (AFPS) Conference, Bangkok, Thailand, November 25-27 (2015)
- Therapeutic Approach of Familial Amyloidotic Polyneuropathy by Targeted Delivery of siRNA Complex with PEG-appended Lactosylated Dendrimer/cyclodextrin Conjugate
Y. Hayashi, T. Higashi, K. Motoyama, H. Jono, Y. Ando, H. Arima
Asian Federation for Pharmaceutical Sciences (AFPS) Conference, Bangkok, Thailand, November 25-27 (2015)
- Anti-inflammatory Effects of Polysaccharide Sacran Extracted from Cyanobacterium Aphanothece sacrum in Various Inflammatory Animal Models
K. Motoyama, Y. Tanida, K. Hata, T. Hayashi, T. Higashi, Y. Ishitsuka, Y. Kondo, T. Irie, S. Kaneko, H. Arima
7th Annual and 1st International Symposium on Sacran, Kitakyushu, Japan, November 21 (2015)
- Fabrication and Characterization of Novel Sacran Films Containing Cyclodextrins for Wound Dressing Application
N. Wathoni, K. Motoyama, T. Higashi, Y. Ishitsuka, Y. Kondo, T. Irie, S. Kaneko, M. Okajima, T. Kaneko, H. Arima
7th Annual and 1st International Symposium on Sacran, Kitakyushu, Japan, November 21 (2015)
- Stabilization of Proteins Encapsulated in Injectable Polypseudorotaxane Hydrogels
K. Motoyama, N. Ohshita, A. Tajima, T. Higashi, R. Iibuchi, S. Koyama, S. Mieda, T. Uchida, K. Handa, T. Kimoto, H. Arima
PEGS Europe 2015, Lisbon, Portugal, November 6 (2015).
- Preparation and evaluation of gluculonylglucosyl-β-cyclodextrin/dendrimer (G3) conjugate as a novel siRNA carrier
A. Fouad Abdelwahab Mohammed, A. Ohyama, T. Higashi, K. Motoyama, K. A. Khaled, H. A. Sarhan, A. K. Hussein, H. Arima
International Symposium on Chronic Inflammatory Diseases, Kumamoto, Japan, October 16-17 (2015).
- Fabrication and Characterization of Novel Sacran Films Containing Cyclodextrins for Biomedical Application
N. Wathoni, K. Motoyama, T. Higashi, Y. Ishitsuka, Y. Kondo, T. Irie, S. Kaneko, M. Okajima, T. Kaneko, H. Arima
International Symposium on Chronic Inflammatory Diseases, Kumamoto, Japan, October 16-17 (2015).
- Folate-appended β-Cyclodextrins as Promising Tumor Targeting Carriers for Antitumor Drugs
Y. Tanida, M. Taniyoshi, A. Okamatsu, K. Hattori, K. Motoyama, T. Higashi, H. Arima
Joint Conference of 8th Asian Cyclodextrin Conference and 32nd Cyclodextrin Symposium, Kumamoto, Japan, May 14-16 (2015).
- Cyclodextrin-based Supramolecular PEGylation for Protein Drugs
T. Higashi, T. Hirotsu, I.I. Abu Hashim, K. Wada, K. Motoyama, H. Arima
The 5th International Conference on Bio-based Polymers, Singapore, June 24-27 (2015).
- Folate-appended β-Cyclodextrins as Promising Tumor Targeting Carriers for Antitumor Drugs
Y. Tanida, M. Taniyoshi, A. Okamatsu, K. Hattori, K. Motoyama, T. Higashi, H. Arima
Joint Conference of 8th Asian Cyclodextrin Conference and 32nd Cyclodextrin Symposium, Kumamoto, Japan, May 14-16 (2015).
- Treatment Efficacy of NF-κB siRNA Complex with Thioalkylated Mannose-Modified Dendrimer (G3)/α-Cyclodextrin Conjugate for Fulminant Hepatitis Model Mice
N. Sato, R. Mitsuyasu, C. Akao, T. Tanaka, K. Motoyama, T. Higashi, H. Arima
Joint Conference of 8th Asian Cyclodextrin Conference and 32nd Cyclodextrin Symposium, Kumamoto, Japan, May 14-16 (2015).
- Preparation of Insulin Conjugate with Glucuronylglucosyl-β-cyclodextrin and Evaluation of Its Pharmaceutical Properties
M. Sugio, T. Hirotsu, T. Higashi, K. Motoyama, F. Hirayama, K. Uekama, H. Arima
Joint Conference of 8th Asian Cyclodextrin Conference and 32nd Cyclodextrin Symposium, Kumamoto, Japan, May 14-16 (2015).
- Design and Evaluation of Fucose-appended Dendrimer/α-Cyclodextrin Conjugate as a NF-κB Decoy Carriers for the Treatment of Fulminant Hepatitis
I. Kuwano, C. Akao, K. Motoyama, T. Higashi, H. Arima
Joint Conference of 8th Asian Cyclodextrin Conference and 32nd Cyclodextrin Symposium, Kumamoto, Japan, May 14-16 (2015).
- Potential Use of Cyclodextrin Polypseudorotaxane with PEGylated Liposome as a Controlled Release Drug Carrier
Y. Yamashita, D. Kono, K. Hayashida, T. Higashi, K. Motoyama, K. Wada, H. Arima
Joint Conference of 8th Asian Cyclodextrin Conference and 32nd Cyclodextrin Symposium, Kumamoto, Japan, May 14-16 (2015).
- Preparation and Evaluation of Mannosyloxypropylthiopropionylated Dendrimer/α-Cyclodextrin Conjugates (G3) as DNA Vaccine Carriers
Y. Abe, S. Hirata, T. Tanaka, K. Motoyama, T. Higashi, H. Arima
Joint Conference of 8th Asian Cyclodextrin Conference and 32nd Cyclodextrin Symposium, Kumamoto, Japan, May 14-16 (2015).
- Potential Use of Polypseudorotaxanes of PEGylated Polyamidoamine Dendrimer/Cyclodextrin Conjugate as a Sustained Release System for siRNA
K. Morita, S. Hirata, T. Higashi, K. Motoyama, H. Arima
Joint Conference of 8th Asian Cyclodextrin Conference and 32nd Cyclodextrin Symposium, Kumamoto, Japan, May 14-16 (2015).
- Effects of Lactosylated Cyclodextrin on Free Cholesterol Accumulation in NPC-like Liver Cancer Cells
R. Nishiyama, Y. Hirai, K. Motoyama, T. Higashi, Y. Ishitsuka, Y. Kondo, T. Irie, T. Era, H. Arima
Joint Conference of 8th Asian Cyclodextrin Conference and 32nd Cyclodextrin Symposium, Kumamoto, Japan, May 14-16 (2015).
- Stabilization of Highly-concentrated Human IgG Using Cyclodextrin Polypseudorotaxane Hydrogels
N. Ohshita, A. Tajima, T. Higashi, K. Motoyama, S. Koyama, R. Iibuchi, S. Mieda, K. Handa, T. Kimoto, H. Arima
Joint Conference of 8th Asian Cyclodextrin Conference and 32nd Cyclodextrin Symposium, Kumamoto, Japan, May 14-16 (2015).
- Potential Use of Folate-PEG-appended Dendrimer (G4) Conjugate with α-Cyclodextrin as a Tumor-targeting siRNA Carrier
A. Ohyama, T. Higashi, K. Motoyama, H. Arima
Joint Conference of 8th Asian Cyclodextrin Conference and 32nd Cyclodextrin Symposium, Kumamoto, Japan, May 14-16 (2015).
- Cyclodextrin-based Self-assembly PEGylation Technique Retaining Activity of Protein Drugs
T. Hirotsu, T. Higashi, I.I. Abu Hashim, K. Motoyama, K. Wada, H. Arima
Joint Conference of 8th Asian Cyclodextrin Conference and 32nd Cyclodextrin Symposium, Kumamoto, Japan, May 14-16 (2015).
- Hepatocyte Targeted Delivery of siRNA Complex with PEG-appended Lactosylated Dendrimer/Cyclodextrin Conjugate for Treatment of Hereditary Amyloidosis
Y. Hayashi, T. Higashi, K. Motoyama, H. Jono, Y. Ando, H. Arima
Joint Conference of 8th Asian Cyclodextrin Conference and 32nd Cyclodextrin Symposium, Kumamoto, Japan, May 14-16 (2015).
- Fabrication and Characterization of Novel Sacran Films Containing Cyclodextrins
N. Wathoni, K. Motoyama, T. Higashi, Y. Ishitsuka, Y. Kondo, T. Irie, S. Kaneko, M. Okajima, T. Kaneko, H. Arima
Joint Conference of 8th Asian Cyclodextrin Conference and 32nd Cyclodextrin Symposium, Kumamoto, Japan, May 14-16 (2015).
- Effects of Cyclodextrins on GM1-gangliosides in Fibroblasts from GM1-gangliosidosis Patients
Y. Maeda, K. Motoyama, T. Higashi, Y. Horikoshi, T. Takeo, N. Nakagata, Y. Kurauchi, H. Katsuki, Y. Kondo, Y. Ishitsuka, T. Irie, T. Era, H. Arima
Joint Conference of 8th Asian Cyclodextrin Conference and 32nd Cyclodextrin Symposium, Kumamoto, Japan, May 14-16 (2015).
- Thermoresponsive Formation of Dimethyl Cyclodextrin Polypseudorotaxanes and One-pot Synthesis of Polyrotaxanes
T. Higashi, Jun Li, Xia Song, Jingling Zhu, M. Taniyoshi, F. Hirayama, K. Motoyama, H. Arima
Joint Conference of 8th Asian Cyclodextrin Conference and 32nd Cyclodextrin Symposium, Kumamoto, Japan, May 14-16 (2015).
- Folate-appended Methyl-β-cyclodextrin as a Novel Autophagic Cell Death Inducer
K. Motoyama, N. Tanaka, R. Onodera, T. Higashi, H. Arima
Joint Conference of 8th Asian Cyclodextrin Conference and 32nd Cyclodextrin Symposium, Kumamoto, Japan, May 14-16 (2015).
- Design and Evaluation of the Highly-concentrated Human IgG Formulation Using Cyclodextrin Polypseudorotaxane Hydrogels
N. Ohshita, A. Tajima, T. Higashi, K. Motoyama, S. Koyama, R. Iibuchi, S. Mieda, K. Handa, H. Arima
2014 AAPS Annual Meeting and Exposition, San Diego, U.S.A., Nov 2-6 (2014).
- Anti-inflammatory Effects of Megamolecular Polysaccharide Sacran in Various Experimental Inflammatory Models
Y. Tanida, K. Motoyama, T. Higashi,S. Kaneko, Y. Kondo, Y, Ishizuka, T. Irie, H. Arima
2014 AAPS Annual Meeting and Exposition, San Diego, U.S.A., Nov 2-6 (2014).
- Potential Use of Thioalkylated Mannose-modified Dendrimer/Cyclodextrin Conjugate as a Novel Antigen Presenting Cell-selective siRNA Carrier
N. Sato, R. Mitsuyasu, T. Tanaka, K. Motoyama, T. Higashi, H. Arima
2014 AAPS Annual Meeting and Exposition, San Diego, U.S.A., Nov 2-6 (2014).
- Preparation and Evaluation of Folate-PEG-appended Dendrimer (G4) Conjugate with α-Cyclodextrin as a Tumor-targeting siRNA Carrier
A. Ohyama, H. Ikeda, T. Higashi, K. Motoyama, H. Arima
2014 AAPS Annual Meeting and Exposition, San Diego, U.S.A., Nov 2-6 (2014).
- Potential Application of Cyclodextrin Polypseudorotaxanes as Sustained Release Carriers for Various Types of Drugs
H. Arima, T. Higashi, K. Motoyama
2014 AAPS Annual Meeting and Exposition, San Diego, U.S.A., Nov 2-6 (2014).
- Effects of Cyclodextrin Derivatives on GM1 Ganglioside in Fibroblasts Differentiated from iPS Cells Derived from GM1 Gangliosidosis Patients
Y. Maeda, K. Motoyama, T. Higashi, Y. Horikoshi, T. Takeo, N. Nakagata, Y. Kurauchi, H. Katsuki, Y. Ishitsuka, Y. Kondo, T. Irie, T. Era, H. Arima
17th International Cyclodextrin Symposium, Saarbrücken, Germany, May 29-31 (2014).
- Potential Use of PEG-appended Lactosylated Dendrimer/Cyclodextrin Conjugate as a Hepatocyte-selective siRNA Carrier for the Treatment of Familial Amyloidotic Polyneuropathy
Y. Hayashi, T. Higashi, K. Motoyama, H. Jono, Y. Ando, H. Arima
17th International Cyclodextrin Symposium, Saarbrücken, Germany, May 29-31 (2014).
- Potential Use of Cyclodextrin Polypseudorotaxanes as Sustained Release Drug Carriers for Low Molecular Weight Drugs, Protein Drugs and Gene Drugs
T. Higashi, I.I. Abu Hashim, K. Hayashida, A. Tajima, D. Kono, K. Motoyama, H. Arima
17th International Cyclodextrin Symposium, Saarbrücken, Germany, May 29-31 (2014).
- Potential Use of Folate-appended Methyl-β-Cyclodextrin as a Novel Anticancer Agent
K. Motoyama, R. Onodera, N. Tanaka, A. Ohyama, A. Okamatsu, T. Higashi, R. Kariya, S. Okada, H. Arima
17th International Cyclodextrin Symposium, Saarbrücken, Germany, May 29-31 (2014).
- Lactosylated Dendrimer/α-Cyclodextrin Conjugates for Systemic Delivery of Transthyretin siRNA into Hepatocytes for Treatment of Familial Amyloidotic Polyneuropathy
H. Arima (Invited speaker)
10th International Symposium on Polymer Therapeutics: From Laboratory to Clinical Practice, Valencia, Spain, May 19-21 (2014).
- Feasibility Study of Hydrophilic Cyclodextrin Derivatives as Drugs for GM1-Gangliosidosis.
Y. Maeda, K. Motoyama, T. Higashi, Y. Horikoshi, T. Takeo, N. Nakagata, Y. Kurauchi, H. Katsuki, Y. Ishizuka, T. Irie, T.Era, H. Arima
7th Asian Cyclodextrin Conference, Bangkok, Thailand, Nov 27-29 (2013).
- Design and Evaluation of Mannosyloxypropylthiopropionylated Dendrimer/α-Cyclodextrin Conjugates (G3) as a DNA Vaccine Carrier.
S. Hirata, T. Tanaka, K. Motoyama, T. Higashi, H. Arima
7th Asian Cyclodextrin Conference, Bangkok, Thailand, Nov 27-29 (2013).
- Design and Evaluation of PEGylated Insulin Retaining its Bioactivity via the Supramolecular Complexation with Cyclodextrin.
T. Hirotsu, T. Higashi, K. Motoyama, H. Arima
7th Asian Cyclodextrin Conference, Bangkok, Thailand, Nov 27-29 (2013).
- Potential Use of Cyclodextrins as Drug Delivery Carriers and Active Pharmaceutical Ingredients.
H. Arima, K. Motoyama, T. Higashi
7th Asian Cyclodextrin Conference, Bangkok, Thailand, Nov 27-29 (2013).
- Dendrimer Conjugates with Cyclodextrins as Carriers for Drugs, Genes and siRNA.
H. Arima, K. Motoyama, T. Higashi
2013 AAPS Annual Meeting and Exposition, Texas, USA, Nov 10-14 (2013).
- Design and evaluation of integrated drug delivery system using cyclodextrin.
H. Arima
3rd European Conference on Cyclodextrins, Antalya, Turkey, Oct 2-4 (2013).
- Cyclodextrin Polypseudorotaxanes as Sustained Release Drug Carriers for Low Molecular Weight Drugs, Protein Drugs and Gene Drugs
T. Higashi, I.I. Abu Hashim, K. Hayashida, A. Tajima, D. Kono, K. Motoyama, H. Arima
5th Asian Arden Conference, Nagoya, Japan, Aug 5-6 (2013).
- Folate-PEG-appended dendrmer (G4) conjugate with α-cyclodextrin as a novel cancer cell-selective siRNA carrier.
H. Arima, A. Ohyama, H. Ikeda, K. Motoyama, T. Higashi,
5th Asian Arden Conference, Nagoya, Japan, Aug 5-6 (2013).
- Potential Use of Mannosyloxypropylthiopropionylated Dendrimer/α-Cyclodextrin Conjugate as a Novel Antigen-presenting Cell-selective siRNA Carrier
R. Mitsuyasu, T. Tanaka, R. Onodera, K. Motoyama, T. Higashi, H. Arima
5th Asian Arden Conference, Nagoya, Japan, Aug 5-6 (2013).
- Design and Evaluation of Mannosyloxypropylthiopropionylated Dendrimer/α-Cyclodextrin Conjugates (G2) as a DNA Vaccine Carrier
S. Hirata, T. Tanaka, K. Motoyama, T. Higashi, H. Arima
5th Asian Arden Conference, Nagoya, Japan, Aug 5-6 (2013).
- Involvement of Autophagic Cell-death in Antitumor Activity of Folate-appended Methyl-β-Cyclodextrin
N. Tanaka, R. Onodera, A. Okamatsu, T. Higashi, K. Motoyama, H. Arima
5th Asian Arden Conference, Nagoya, Japan, Aug 5-6 (2013).
- Potential Use of Folate-appended Methyl-ß-cyclodextrin as a Novel Antitumor Drug Carrier.
T. Higashi, R. Onodera, K. Motoyama, A. Okamatsu, H. Arima
40th Annual Meeting & Exposition of the Controlled Release Society, Honolulu, Hawaii, USA, Jul 21-24 (2013).
- Design and Evaluation of PEG-appended Lactosylated Dendrimer/Cyclodextrin Conjugate as a Novel Hepatocyteselective siRNA Carrier for Familial Amyloidotic Polyneuropathy Therapy.
Y. Hayashi, Y. Mori, S. Yamashita, T. Higashi, K. Motoyama, H. Jono, Y. Ando, H. Arima
40th Annual Meeting & Exposition of the Controlled Release Society, Honolulu, Hawaii, USA, Jul 21-24 (2013).
- Potential use of NF-kB Decoy Complex with Fucose-appended Dendrimer/α-cyclodextrin Conjugate for Treatment of Fulminant Hepatitis.
C. Akao, R. Onodera, R. Mitsuyasu, K. Motoyama, T. Higashi, H. Arima
40th Annual Meeting & Exposition of the Controlled Release Society, Honolulu, Hawaii, USA, Jul 21-24 (2013).
- Preparation and Evaluation of Folate-PEG-appended Dendrimer (G4) Conjugate with α-cyclodextrin as a Cancer Cell-selective siRNA Carrier
A. Ohyama, H. Ikeda, T. Higashi, K. Motoyama, H. Arima
40th Annual Meeting & Exposition of the Controlled Release Society, Honolulu, Hawaii, USA, Jul 21-24 (2013).
- Potential Use of Folate-appended ß-Cyclodextrins as TumorTargeting Carriers for Antitumor Drugs
H. Arima, A. Okamatsu, K. Motoyama, R. Onodera, T. Higashi, T. Koshigoe, Y. Shimada, K. Hattori, T. Takeuchi
40th Annual Meeting & Exposition of the Controlled Release Society, Honolulu, Hawaii, USA, Jul 21-24 (2013).
- Application of Cyclodextrins as Drug Carriers and Active Pharmaceutical Ingredients
T. Higashi, K. Motoyama, H. Arima
Kumamoto Symposium on Supramolecular, Nano and Coordination Chemistry, Kumamoto, Japan, Jul 10 (2013).
- Cyclodextrin/PEG Polypseudorotaxane Hydrogels as a Promising Sustained Release System for Protein Drugs
H. Arima, A. Tajima, I.I. Abu Hashim, T. Higashi, K. Motoyama
The 9th International Gel Symposium, Tsukuba, Japan, Oct 9-12 (2012).
- Design and Evaluation of Insulin Conjugate with Glucuronylglucosyl-β-cyclodextrin for Stabilization of Bioactive Insulin
T. Hirotsu, T. Higashi, K. Motoyama, F.Hirayama, K. Uekama, H. Arima
The 16th International Cyclodextrin Symposium, Tianjin, China, May 6-10 (2012).
- Synergistic Inhibitory Effects of Cyclodextrins and Polyamidoamine Dendrimer on Chemically-induced Aggregation of Lysozyme
T. Higashi, K. Arima, K. Motoyama, H. Arima
The 16th International Cyclodextrin Symposium, Tianjin, China, May 6-10 (2012).
- Cyclodextrin/poly(ethylene glycol) Polypseudorotaxane Hydrogels Encapsulating Lysozyme: Sustained Release of Lysozyme from the Hydrogels and Its Mechanism
K. Watanabe, A. Tajima, T. Higashi, K. Motoyama, H. Arima
The 16th International Cyclodextrin Symposium, Tianjin, China, May 6-10 (2012).
- Preparation and Evaluation of Thioalkylmannosylated Dendrimer/α-Cyclodextrin Conjugate as a Novel Antigen-presenting Cell-selective siRNA Carrie
R. Mitsuyasu, T. Tanaka, R. Onodera, K. Motoyama, T. Higashi, H. Arima
The 16th International Cyclodextrin Symposium, Tianjin, China, May 6-10 (2012).
- Cyclodextrin Polypseudorotaxanes of Pegylated α-Cyclodextrin/polyamidoamine Dendrimer (G2) Conjugate as a Sustained Release System for siRNA
S. Hirata, K. Hayashida, K. Motoyama, T. Higashi, H. Arima
The 16th International Cyclodextrin Symposium, Tianjin, China, May 6-10 (2012).
- Systemic Delivery of Transthyretin siRNA Mediated by Lactosylated Dendrimer/α-Cyclodextrin Conjugates into Hepatocyte
Y. Hayashi, Y. Mori, T. Higashi, K. Motoyama, H. Jono, D. Sah, Y. Ando, H. Arima
Ⅷ ThInternational Symposium on Familial Amyloidotic Polyneuropathy, Kumamoto, Japan, Nov 20-22 (2011).
- Polypseudorotaxanes of PEGylated Polyamidomine Dendrimer with Cyclodextrins : Application to Sustained Release System for DNA Delivery
T. Higashi, K. Hayashida, K. Motoyama, H. Arima
The 6th Asian Cyclodextrin Conference, Canberra, Australia, Aug 28-31 (2011).
- Cellular uptake and intracellular behavior of dendrimer (G2)/branched β-cyclodextrin conjugate
T Anno, T Higashi, K Motoyama, F Hirayama, K Uekama, H Arima
The 6th Asian Cyclodextrin Conference, Canberra, Australia, Aug 28-31 (2011).
- Preparation and Evaluation of Folate-appended Methyl-β-Cyclodextrin as New Antitumor Agents
R. Onodera, A. Okamatsu, T. Higashi, K. Motoyama, H. Arima.
The 6th Asian Cyclodextrin Conference, Canberra, Australia, Aug 28-31 (2011).
- Preparation and Evaluation of Polypseudorotaxanes of PEGylated Polyamidomine Dendrimer with Cyclodextrins as Sustained Release Systems for DNA
T. Higashi, K. Hayashida, K. Motoyama, H. Arima
The 10th China-Japan-Korea Foresight Joint Symposium on Gene Delivery and International Symposium on Biomaterials 2011, Guilin, China, May 29-Jun 2 (2011).
- Design and Evaluation of Folate-appened Methyl-β-Cyclodextrin as New Antitumor Agents
R. Onodera, T. Akao, K. Motoyama, H. Arima,
The FIP World Congress 2010 in conjunction with AAPS annual meeting, New Orleans, Louisiana, USA, Nov14-18 (2010).
- PAMAM Dendrimer (G2)/glucuronylglucosyl-β-cyclodextrin Conjugate for a Novel Gene Transfer Carrier
T. Anno, K. Motoyama, F. Hirayama, K. Uekama, H. Arima,
The FIP World Congress 2010 in conjunction with AAPS annual meeting, New Orleans, Louisiana, USA, Nov14-18 (2010).
- Folate-PEG-appended-PAMAM Dendrimer (G3) Conjugate with α-Cyclodextrin as a Tumor Selective siRNA Carrier
H. Arima, A. Yoshimatsu, H. Ikeda, K. Motoyama, F. Hirayama, K. Uekama,
The FIP World Congress 2010 in conjunction with AAPS annual meeting, New Orleans, Louisiana, USA, Nov14-18 (2010).
- Evaluation of PAMAM Dendrimer (G2)/Branched-β-cyclodextrin Conjugate as a Novel Gene Transfer Carrier
T. Anno, T. Higashi, K. Motoyama, F. Hirayama, K. Uekama, H. Arima
The 2nd Young Scientist Exchenge Symposium for A3 Foresight Prograam in Daejeon, Seoul, Korea, Jul4-7 (2010).
- Potential Use of Iontophoresis for Transdermal Delivery of NF-κB Decoy
M. Nakahara,I.I. Hashim, K. Motoyama, A.E. Abd-ElGawad, M.H. El-Shabouri, T. Borg, H. Arima
The 2nd Young Scientist Exchenge Symposium for A3 Foresight Prograam in Daejeon, Seoul, Korea, Jul4-7 (2010).
- Design and Evaluation of Folate-appended Methyl-β-Cyclodextrin as Novel Anti-tumor Agents
R. Onodera, K. Motoyama, H. Arima
The 2nd Young Scientist Exchenge Symposium for A3 Foresight Prograam in Daejeon, Seoul, Korea, Jul4-7 (2010).
- Potential Use of PAMAM Dendrimer (G3) Conjugates as Novel Carriers of DNA and RNA
H. Arima
The 9th China-Japan-Korea Foresight Joint Symposium on Gene Delivery and International Workshop on Biomaterials 2010, Changchun, China, Jun20-23 (2010).
- Hydrophilic C60/Hydroxypropyl-β-cyclodextrin Nanoparticles: Superior Generation of Reactive Oxygen Species
M. Hiratsuka, D. Iohara, F. Hirayama, K. Takeshita, T. Masumizu, K. Motoyama, H. Arima, K. Uekama
The 15th International Cyclodextrin Symposium, Vienna, Austria, May9-12 (2010).
- Preparation and Evaluation of PAMAM Dendrimer(G2)/Branched-β-cyclodextrin Conjugate as a Novel Gene Transfer Carrier
H. Arima, T. Anno, T. Higashi, K. Motoyama, F. Hirayama, K. Uekama
The 15th International Cyclodextrin Symposium, Vienna, Austria, May9-12 (2010).
- Design and Evaluation of Folate-appended Methyl-β-Cyclodextrin as New Antitumor Agents
R. Onodera, K. Motoyama, H. Arima
The 15th International Cyclodextrin Symposium, Vienna, Austria, May9-12 (2010).
- Potential Use of Lactosylated Dendrimer(G2)/α-Cyclodextrin Conjugate as a Hepatic Parenchymal Cell-selective Gene Delivery Carrier in Mice
K. Motoyama, Y. Mori, S. Yamashita, K. Hattori, T. Takeuchi, H. Jono, Y. Ando, F. Hirayama, K. Uekama, H. Arima
The 15th International Cyclodextrin Symposium, Vienna, Austria, May9-12 (2010).
- Pharmaceutical Evaluation of 2-Hydroxybutyl-β-cyclodextrin as Drug Carrier: Dissolution Studies Using Flow-through Cell Apparatus
E. Morishita, D. Iohara, T. Ishiguro, K. Wada, F. Hirayama, K. Motoyama, H. Arima, K. Uekama
The 15th International Cyclodextrin Symposium, Vienna, Austria, May9-12 (2010).
- In Vitro and In Vivo Gene Delivery Mediated by Folate-PEG Appended Dendrimer/α-Cyclodextrin Conjugates into Tumor Cells
H. Arima, A. Yoshimatsu, M. Arizono, H. Ikeda, K. Motoyama, K. Hattori, T. Takeuchi, F. Hirayama, K. Uekama
The 2009 AAPS Annual Meeting and Exposition, Los Angeles, CA, USA, Nov8-12 (2009).
- POTENTIAL USE OF LACTOSYLATED DENDRIMER (G2)/α-CYCLODEXTRIN CONJUGATE AS A HEPATOCYTE-SPECIFIC GENE DELIVERY CARRIER IN HEPG2 CELLS AND MICE
H. Arima, Y. Mori, S. Yamashita, K. Motoyama, K. Hattori, T. Takeuchi, Y. Misumi, H. Jono, Y. Ando, F. Hirayama, K. Uekama
Joint Symposium of the 5th Annual Meeting of the Oligonucleotide Therapeutics Society and the 19th Antisense Symposium, Fukuoka, Japan, Nov3-6 (2009).
- FOLATE-PEG-APPENDED-PAMAM DENDRIMER (G3) CONJUGATE WITH α-CYCLODEXTRIN AS A TUMOR-SELECTIVE GENE TRANSFER CARRIER
A. Yoshimatsu, M. Arizono, H. Ikeda, K. Motoyama, K. Hattori, T. Takeuchi, F. Hirayama, K. Uekama, H. Arima
Joint Symposium of the 5th Annual Meeting of the Oligonucleotide Therapeutics Society and the 19th Antisense Symposium, Fukuoka, Japan, Nov3-6 (2009).
- PREPARATION AND EVALUATION OF PAMAM DENDRIMER (G2) CONJUGATE WITH GLUCURONYLGLUCOSYL-β-CYCLODEXTRIN AS A NOVEL GENE TRANSFER CARRIER
K. Anno, K. Hayashida, T. Higashi, K. Motoyama, F. Hirayama, K. Uekama, H. Arima
Joint Symposium of the 5th Annual Meeting of the Oligonucleotide Therapeutics Society and the 19th Antisense Symposium, Fukuoka, Japan, Nov3-6 (2009).
- Gene Deivery Mediated by Folate-PEG Appended Dendrimer (G3)/α-Cyclodextrin Conjugates into Tumor Cells
H. Arima, A. Yoshimatsu, M. Arizono, H. Ikeda, K. Motoyama, K. Hattori, T. Takeuchi, F. Hirayama, K. Uekama
Asian Federation for Pharmaceutical Sciences 2009, Fukuoka, Japan, Oct16-17 (2009).
- Preparation of Hydrophilic Nanoparticles of C60 Using 2-Hydroxypropyl-β-cyclodextrin and It's Superoxide Anion Generation Efficiency
D. Iohara, F. Hirayama, M. Hiratsuka, H. Kansui, H. Aoshima, S. Yamana, K. Motoyama, H. Arima, K. Uekama
Asian Federation for Pharmaceutical Sciences 2009, Fukuoka, Japan, Oct16-17 (2009).
- Potential Use of PAMAM Dendrimer (G3) Conjugates with α-cyclodextrin as a Novel Carrier of siRNA
H. Arima (invited speaker), A. Yoshimatsu, T. Toshihito, K. Motoyama, F. Hirayama, K. Uekama
Roche Marco Polo Symposium 2009: 3rd Roche Drug Delivery Symposium in Far East, The Ritz Carlton Hotel, Seoul, Korea, Sep15-16 (2009).
- Potential Use of PAMAM Dendrimer (G2) Conjugates with Glucuronylglucosyl-β-cyclodextrin as a Novel Gene Transfer Carrier
T. Anno, T. Higashi, K. Motoyama, F. Hirayama, K. Uekama, H. Arima
Roche Marco Polo Symposium 2009: 3rd Roche Drug Delivery Symposium in Far East, The Ritz Carlton Hotel, Seoul, Korea, Sep15-16 (2009).
- In Vitro and In Vivo Gene Delivery Mediated by Lactosylated Dendrimer/a-cyclodextrin Conjugates into Hepatocytes
H. Arima (invited speaker), S. Yamashita, Y. Mori, K. Motoyama, K. Hattori, T. Takeuchi, F. Hirayama, K. Uekama
The 7th A3 (China-Japan-Korea) Foresight Meeting on Gene Therapy in Conjunction with International Symposium on Biomaterials and Drug Delivery Systems, KIST, Seoul, Korea, May25-26 (2009).
- DNA Delivery Using a Folate-appended Carrier
R. Onodara, A. Yoshimatsu, M. Arizono, H. Ikeda, K. Motoyama, K. Hattori, T. Takeuchi, F. Hirayama, K. Uekama, H. Arima.
The 7th A3 (China-Japan-Korea) Foresight Meeting on Gene Therapy in Conjunction with International Symposium on Biomaterials and Drug Delivery Systems, KIST, Seoul, Korea, May25-26 (2009).
- Preparation and Evaluation of Cyclodextrin Supramolecular Complex with Teprenone, an Isoprenoid Compound
H. Tanaka, H. Ikeda, K. Motoyama, F. Hirayama, K. Uekama, H. Arima
The 7th A3 (China-Japan-Korea) Foresight Meeting on Gene Therapy in Conjunction with International Symposium on Biomaterials and Drug Delivery Systems, KIST, Seoul, Korea, May25-26 (2009).
- Effects of 2,6-Di-O-Methyl-α-cyclodextrin on Nitric Oxide (NO) Production from Macrophages Stimulated with Poly I:C, a Toll-like Receptor III Ligand
K. Motoyama (Poster Award, The Grand Prize), Y. Hashimoto, F. Hirayama, K. Uekama, H. Arima
The 5th Asian Cyclodextrin Conference, Pusan National University, Busan, Korea, May13-16 (2009).
- In Vitro and In Vivo Gene Delivery Mediated by Lactosylated Dendrimer/α-cyclodextrin Conjugates into Hepatocytes
Y. Mori (Poster Award, The Encouragement Prize), S. Yamashita, K. Motoyama, F. Hirayama, K. Uekama, H. Arima
The 5th Asian Cyclodextrin Conference, Pusan National University, Busan, Korea, May13-16 (2009).
- PAMAM Dendrimer (G3) Conjugate with α-cyclodextrin as a Novel Carrier of siRNA
H. Arima (invited speaker), T. Tsutsumi, F. Hirayama, K. Uekama
The 5th A3 (China-Japan-Korea) Foresight Meeting on Gene Therapy in Conjunction with International Symposium on Biomaterials and Drug Delivery Systems, POSTEC, Pohang, Korea, Jun11-13 (2008).
- Preparation and Evaluation of PAMAM Dendrimer Conjugate with Glucuronylglucosyl-β-cyclodextrin as a Gene Carrier
T. Anno, T. Higashi, F. Hirayama, K. Uekama. H. Arima
The 5th A3 (China-Japan-Korea) Foresight Meeting on Gene Therapy in Conjunction with International Symposium on Biomaterials and Drug Delivery Systems, POSTEC, Pohang, Korea, Jun11-13 (2008).
- Folate-PEG-appended-PAMAM Dendrimer Conjugate with α-Cyclodextrin as a Novel Cancer Cell-selective Gene Carrier
A. Yoshimatsu, M. Arizono, K. Hattori, T. Takeuchi, F. Hirayama, K. Uekama, H. Arima
The 5th A3 (China-Japan-Korea) Foresight Meeting on Gene Therapy in Conjunction with International Symposium on Biomaterials and Drug Delivery Systems, POSTEC, Pohang, Korea, Jun11-13 (2008).
- Design and evaluation of PAMAM dendrimer conjugates with cyclodextrins for novel carriers of gene and siRNA
H. Arima (invited speaker), F. Hirayama, K. Uekama
14th International Cyclodextrin Symposium, Kyoto, Japan, May8-11 (2008).
- Change in crystal habit of aspirin by the addition of cyclodextrins in aqueous solution
K. Yoshida, F. Hirayama, D. Iohara, K. Yamaguchi, Y. Yoshitake, K, Harano, H. Arima, K. Uekama
14th International Cyclodextrin Symposium, Kyoto, Japan, May8-11 (2008).
- Folate-PEG-appended-dendrimer conjugate with α-cyclodextrin as novel cancer cell-selective gene transfer carrier
A. Yoshimatsu, M. Arizono, K. Hattori, T. Takeuchi, F. Hirayama, K. Uekama, H. Arima
14th International Cyclodextrin Symposium, Kyoto, Japan, May8-11 (2008).
- Inhibitory effect of 2,6-di-O-methyl-α-cyclodextrin on Poly I:C signaling in macrophages
H. Arima, Y. Hashimoto, K. Motoyama, F. Hirayama, K. Uekama
14th International Cyclodextrin Symposium, Kyoto, Japan, May8-11 (2008).
- Design and evaluation of polypseudorotaxanes of PEGylated insulin with cyclodextrins as sustained release system
K. Uekama, F. Hirayama, T. Higashi, H. Arima
9th US-JAPAN Symposium on Drug Delivery Systems, Lahaina, Hawaii, USA, Dec16-20 (2007).
- Polypseudorotaxanes of pegylated insulin with cyclodextrins for sustained release system
T. Higashi, F. Hirayama, H. Arima, K. Uekama
1st Asian Pharmaceutical Science and Technology Symposium, Shenyang, China, Jul28-30 (2007).
- Cyclodextrin-based Preparation of Amorphous Indomethacin from Aqueous Solition
D. Iohara, F. Hirayama, T. Ishiguro, H. Arima, K. Uekama
1st Asian Pharmaceutical Science and Technology Symposium, Shenyang, China, Jul28-30 (2007).
- Lactosylated dendrimer/α-cyclodextrin conjugate (Lac-α-CDE) for efficient hepatocyte-selective gene transfer in vitro and in vivo
H. Arima, S. Yamashita, M. Arizono, F. Hirayama, K. Uekama
AAPS National Biotechnology Conferance, San Diego, CA, USA, Jun24-27 (2007).
- Potential use of dendrimer/α-cyclodextrin conjugate (α-CDE) as a novel carrier of siRNA
K. Lee, T. Tsutsumi, K. Udo, F. Hirayama, K. Uekama, H. Arima
AAPS National Biotechnology Conferance, San Diego, CA, USA, Jun24-27 (2007).
- Enhancement of gene transfer activity mediated by mannosylated dendrimer/α-cyclodextrin conjugate (Man-α-CDE)
M. Arizono, Y. Chihara, S. Yamashita, F. Hirayama, K. Uekama, H. Arima
AAPS National Biotechnology Conferance, San Diego, CA, USA, Jun24-27 (2007).
- Inhibitory effects of hydrophilic cyclodextrin derivatives on macrophage activation stimulated with toll-like receptor ligands
H. Tanaka, K. Motoyama, Y. Hashimoto, F. Hirayama, K. Uekama, H. Arima
AAPS National Biotechnology Conferance, San Diego, CA, USA, Jun24-27 (2007).
- Effects of β-Cyclodextrin Derivatives on Polymorphic Transition and Crystal Habit of Typical NSAIDs, Indomethacin and Aspirin
K. Uekama, F. Hirayama, D. Iohara, T. Ishiguro, H. Arima
4th Asian Cyclodextrin Conferance, Kyoto, May18-20 (2007).
- In Vitro and In Vivo Hepatocyte-selective Gene Delivery Using Lactosylated PAMAM Dendrimer Conjugate with α-Cyclodextrin
H. Arima, S. Yamashita, M. Arizono, F. Hirayama, K. Uekama
4th Asian Cyclodextrin Conferance, Kyoto, May18-20 (2007).
- Sustained Release System of Pegylated Insulin by Polypseudorotaxane Formation
T. Higashi, F. Hirayama, H. Arima, K. Uekama
4th Asian Cyclodextrin Conferance, Kyoto, May18-20 (2007).
- Cyclodextrins Improve Fertilizing Ability of Mouse Spermatozoa after Freezing and Thawing by Falilitating Cholesterol Efflux from the Cells
T. Takeo, T. Hoshii, Y. Kondo, H. Toyodome, H. Arima, K. Yamamura, N. Nakagawa, T. Irie
4th Asian Cyclodextrin Conferance, Kyoto, May18-20 (2007).
- Formation of Fine Coenzyme Q10 Perticle by Kneading and Co-grinding with γ-Cyclodextrin
K. Nishimura, T. Higashi, M. Arizono, M. Hoshikawa, F, Hirayama, K. Uekama, H. Arima
3rd Pharmaceutical Sciences World Conference, Amsterdam, The Netherlands, Apr22-25 (2007).
- Control of Solution-mediated Polymorphic Transition of Tolubutamide in Aqueous Solution by Dimethy-β-cyclodextrin
F. Hirayama, Y. Sonoda, H. Arima and K. Uekama
The 3rd Asian cyclodextrin conference, Nankai university, China, May8-12 (2005).
- Improvement of Dispersion and Release Profiles of Nifedipine in Suppositories by Complexation with 2-Hydroxypropyl-β-cyclodextrin
K. Nishimura, R. Hidaka, F. Hirayama, H. Arima and K. Uekama
The 3rd Asian cyclodextrin conference, Nankai university, China, May8-12 (2005).
- Potential Use of Dendrimer/α-cyclodextrin Conjugate as a Novel Carrier for Small Interfering RNA (siRNA)
T. Tsutsumi, H. Arima, F. Hirayama and K. Uekama
The 3rd Asian cyclodextrin conference, Nankai university, China, May8-12 (2005).
- Improvement of Some Pharmaceutical Properties of DY-9760E Injection by Sulfobutyl Ether β-cyclodextrin
Y. Nagase, H. Arima, F. Hirayama and K. Uekama
The 15th International Symposium on Microencapsulation, Parma, Italy, Sep18-25 (2005).
- Cyclodextrin-Drug Conjugates for Colonic Delivery
K. Uekama (Invited Speaker)
2004 AAPS Pharmaceutics and Drug Delivery Conference, Philadelphia, PA, USA, Jun7-9 (2004).
- Improvement of Transfection Efficiency Mediated by Glycosylated Dendrimer/α-Cyclodextrin Conjugate
K. Wada, T. Tsutsumi, H. Arima, F. Hirayama, K. Uekama
Pharmaceutical Sciences World Conference, Kyoto, Japan, May29-Jun3 (2004).
- Modification of Biopharmaceutical Properties of Doxorubicin by Cyclodextrin/liposome Carrier
Y. Hagiwara, H. Arima, F. Hirayama, K. Uekama
Pharmaceutical Sciences World Conference, Kyoto, Japan, May29-Jun3 (2004).
- Effects of Bile Acids on Intestinal Absorption of Itraconazole Solution Containing Cyclodextrins
Y. Yamasaki, Y. Hagiwara, K. Miyake, H. Arima, F. Hirayama, K. Uekama
Pharmaceutical Sciences World Conference, Kyoto, Japan, May29-Jun3 (2004).
- Hydrophilic Cyclodextrins as Anti-aggregation for recombinant Human Growth Hormone (rhGH)
S. Tavomvipas, F. Hirayama, H. Arima, K. Uekama
Pharmaceutical Sciences World Conference, Kyoto, Japan, May29-Jun3 (2004).
- Dimethyl-β-cyclodextrin induces Apoptosis in Macrophages
K. Kameyama, H. Arima, F. Hirayama, K. Uekama
Pharmaceutical Sciences World Conference, Kyoto, Japan, May29-Jun3 (2004).
- Dendrimer/α-Cyclodextrin Conjugate as a Novel Carrier of siRNA
H. Arima, T. Tsutsumi, K. Wada, F. Hirayama, K. Uekama
Pharmaceutical Sciences World Conference, Kyoto, Japan, May29-Jun3 (2004).
- Effects of 2-Hydroxypropyl-β-cyclodextrin on Polymorphic Transition of Chlorpropamide
Y. Sonoda, F. Hirayama, H. Arima, K. Uekama
Pharmaceutical Sciences World Conference, Kyoto, Japan, May29-Jun3 (2004).
- Enhancing Mechanism of Oral Bioavailability by Cyclodextrins
H. Arima (Invited Speaker), F. Hirayama, K. Uekama
12th International Cyclodextrin Symposium, Montpiller, France, May16-20 (2004).
- Potential Use of Dendrimer/α-Cyclodextrin Conjugate as a Carrier of Small Interferring RNA (siRNA)
H. Arima, T. Tsutsumi, K. Wada, F. Hirayama, K. Uekama
12th International Cyclodextrin Symposium, Montpiller, France, May16-20 (2004).
- Effects of Branched Cyclodextrins on the Stability of Recombinant Human Growth Hormone
S. Tavomvipas, S. Tajiri, F. Hirayama, H. Arima, K. Uekama
12th International Cyclodextrin Symposium, Montpiller, France, May16-20 (2004).
- Potential Use of Cyclodextrins in Peptide and Protein Delivery
K. Uekama (Invited Speaker)
European Conference on Drug Delivery and Pharmaceutical Technology, Sevilla, Spain, May10-12 (2004).
- Localization and Interaction of Caveolins and Src Family Kinases in Tubulovesicles of Gastric Parietal Cells (rhgh)
H. Arima, Y. Mori, T. Shuto, H. Kai, C.T. Okamoto
The American Society for Cell Biology, San Francisco, CA, Dec13-17 (2003).
- Effects of Hydrophilic Cyclodextrins on the Aggregation of Recombinant Human Growth Hormone (rhgh)
S. Tavornvipas, F. Hirayama, H. Arima, K. Uekama
American Association of Pharmaceutical Sciences, Salt Lake City, Utha, Oct28 (2003).
- Masking Effect of Cyclodextrins on Bitterness of Antihistaminic Drugs: Interaction and Gustatory Test Studies
N. Yoshida, F. Hirayama, H. Arima, K. Uekama
American Association of Pharmaceutical Sciences, Salt Lake City, Utha, Oct28 (2003).
- Effects of Cyclodextrins on Function and Localization of SGLT1 and LAT1 in Caco-2 Cell Monolayers
T. Morikawa, H. Arima, F. Hirayama, K. Uekama
American Association of Pharmaceutical Sciences, Salt Lake City, Utha, Oct28 (2003).
- Dimethylacetyl-β-cyclodextrin As A Novel Antagonist of Septic Shock Induced By Lipopolysaccharide and D-galactosamine in Mice
H. Arima, K. Motoyama, Y. Nishimoto, F. Hirayama, K. Uekama
American Association of Pharmaceutical Sciences, Salt Lake City, Utha, Oct28 (2003).
- Glycosylated Dendrimer/α-cyclodextrin Conjugates as Novel Gene Transfer Agents
T. Tsutsumi, H. Arima, F. Hirayama, K. Uekama
American Association of Pharmaceutical Sciences, Salt Lake City, Utha, Oct28 (2003).
- Gene Delivery Using α-Cyclodextrin/Dendrimer Conjugates
H. Arima
21st Cyclodextrin Symposium in Japan /Asian Cyclodextrin Conference 2003 Satellite: Nano-Science International Symposium: Frontiers of the Nano-Supramolecular Chemistry, Atsugi, Sep18 (2003).
