Journal of Inclusion Phenomena and Macrocyclic Chemistry
44 (1-4): 3-7, December 2002
Copyright © 2002 Kluwer Academic Publishers
All rights reserved
Recent Aspects of Pharmaceutical Application of Cyclodextrins
Kaneto Uekama
Author for correspondence Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1, Oe-honmachi, Kumamoto, 862-0973, Japan
Abstract
Because of the multi-functional characteristics and bioadaptability, cyclodextrin (CyD) is capable of alleviating the undesirable properties of drug molecules through the formation of inclusion complexes. This paper outlines the current application of natural and chemically modified CyDs in the various pharmaceutical formulations including peptide and protein drugs. Furthermore, potential use of CyD/drug conjugates in site-specific drug delivery is discussed.
Keywords
controlled drug release, cyclodextrin derivative, drug carrier, pharmaceutical application, site-specific drug delivery