Chem Commun (Camb). 2006 Feb 4;(5):517-9. Epub 2005 Dec 20. Links

Cyclodextrin-based isolation of Ostwald's metastable polymorphs occurring during crystallization.

Sonoda Y, Hirayama F, Arima H, Yamaguchi Y, Saenger W, Uekama K.

Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan. uekama@gpo.kumamoto-u.ac.jp.

We describe a novel approach for the selective isolation of Ostwald's intermediate metastable polymorphs occurring during an early stage of crystallization, by utilizing the inclusion complex formed with a cyclic oligosaccharide derivative, 2,6-di-O-methyl-b-cyclodextrin.