A moderate interaction of maltosyl-α-cyclodextrin with Caco-2 cells in comparison with the parent cyclodextrin.

Ono, Naomi; Arima, Hidetoshi; Hirayama, Fumitoshi; Uekama, Kaneto.

Faculty of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.

Abstract

The cytotoxicity of maltosyl-α-cyclodextrin (G2-α-CyD) and maltosyl-β-cyclodextrin (G2-β-CyD) toward Caco-2 cells was compared with that of natural α-cyclodextrin (α-CyD), β-cyclodextrin (β-CyD) and γ-cyclodextrin (γ-CyD). The degree of increase in cytotoxicity was dependent on the CyD's type and the concn.: the cytotoxicity of CyDs at the same concn. increased in the order of γ-CyD