研究業績:発表論文リスト(1996年〜)


原著論文

2020年

Nakamura T, Hashikawa C, Okabe K, Yokote Y, Chirifu M, Toma-Fukai S, Nakamura N, Matsuo M, Kamikariya M, Okamoto Y, Gohda J, Akiyama T, Semba K, Ikemizu S, Otsuka M, Inoue J, Yamagata Y
"Structural analysis of TIFA: Insight into TIFA-dependent signal transduction in innate immunity."
[PubMed] Sci. Rep., 10, 5152 (2020)


2019年

Nakamura T, Hirata K, Fujimiya, K.Chirifu M, Arimori T, Tamada T, Ikemizu, Yamagata Y.
"X-ray Structure Analysis of Human Oxidized Nucleotide Hydrolase MTH1 using Crystals Obtained under Microgravity."
[DOI:10.15011//jasma.36.360103] Int. J. Microgravity Sci. Appl., 36, 360103 (2019)


2018年

Fukuda M, Yoshizawa T, Karim MF, Sobuz SU, Korogi W, Kobayasi D, Okanishi H, Tasaki M, Ono K, Sawa T, Sato Y, Chirifu M, Masuda T, Nakamura T, Tanoue H, Nakashima K, Kobashigawa Y, Morioka H, Bober E, Ohtsuki S, Yamagata Y, Ando Y, Oike Y, Araki N, Takeda S, Mizuta H, Yamagata K.
"SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix."
[PubMed] Nature Commun., 9, 2833 (2018)

Hira D, Kitamura R, Nakamura T, Yamagata Y, Furukawa K, Fujii T.
"Anammox Organism KSU-1 Expresses a Novel His/DOPA Ligated Cytochrome c."
[PubMed] J. Mol. Biol., 430, 1189-1200 (2018)


2017年

Waz S, Nakamura T, Hirata K, Koga-Ogawa Y, Chirifu M, Arimori T, Tamada T, Ikemizu S, Nakabeppu Y, Yamagata Y.
"Structural and kinetic studies of the human nudix hydrolase mth1 reveal the mechanism for its broad substrate specificity."
[PubMed][EurekAlert] J. Biol. Chem., 292, 2785-2794 (2017)


2016年

Aoki M, Hayashi H, Yedidi RS, Martyr CD, Takamatsu Y, Aoki-Ogata H, Nakamura T, Nakata H, Das D, Yamagata Y, Ghosh AK, Mitsuya H.
"C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir."
[PubMed] J. Virol., 90, 2180-2194 (2016)


2015年

Kawai A, Higuchi S, Tsunoda M, Nakamauta KT, Yamagata Y, Miyamoto S.
"Crystal structure of family 4 uracil-DNA glycosylase from Sulfolobus tokodaii and a function of tyrosine 170 in DNA binding."
[PubMed] FEBS Lett., 589, 2675-2682 (2015)

Yamaguchi Y, Matsueda S, Matsunaga K, Takashio N, Toma-Fukai S, Yamagata Y, Shibata N, Wachino J, Shibayama K, Arakawa Y. Kurosaki H.
"Crystal Structure of IMP-2 Metallo-β-Lactamase from Acinetobacter spp.: Comparison of Active-Site Loop Structures between IMP-1 and IMP-2."
[PubMed] Biol. Pharm. Bull., 38, 96-101 (2015)


2013年

Koga Y, Inazato M, Nakamura T, Hashikawa C, Chirifu M, Michi A, Yamashita T, Toma S, Kuniyasu A, Ikemizu S, Nakabeppu Y, Yamagata Y.
"Crystallization and preliminary X-ray analysis of human MTH1 with a homogeneous N-terminus."
[PubMed] Acta Cryst., F69, 45-48 (2013)


2012年

Nakamura T, Zhao Y, Yamagata Y, Hua YJ, Yang, W.
"Watching DNA polymerase η make a phosphodiester bond."
[PubMed] Nature, 487, 196-201 (2012)

Takagi Y, Setoyama D, Ito R, Kamiya H, Yamagata Y, Sekiguchi M.
"Human MTH3 (NUDT18) hydrolyzes the oxidized forms of guanosine and deoxyguanosine diphosphates: A comparison with MTH1 and MTH2."
[PubMed] J. Biol. Chem., 287, 21541-21549 (2012)

Shirouzono T, Chirifu M, Nakamura C, Yamagata Y, Ikemizu S.
"Preparation, crystallization and preliminary X-ray diffraction studies of the glycosylated form of human interleukin-23."
[PubMed] Acta Cryst., F68, 432-436 (2012)

Wachino J, Yamaguchi Y, Mori S, Yamagata Y, Arakawa Y, Shibayama K.
"Crystallization and preliminary X-ray analysis of the subclass B3 metallo-β-lactamase SMB-1 that confers carbapenem resistance."
[PubMed] Acta Cryst., F68, 343-346 (2012)

2011年

Arimori, T., Tamaoki, H., Nakamura, T., Kamiya, H., Ikemizu, S., Takagi, Y., Ishibashi, T., Harashima, H., Sekiguchi, M. & Yamagata, Y. (2011) " Diverse Substrate Recognition and Hydrolysis Mechanisms of Human NUDT5." Nucleic Acids Res, 39, 8972-8983

Ito, R., Sekiguchi, M., Setoyama, D., Nakatsu, Y., Yamagata, Y. & Hayakawa, H. (2011) "Cleavage of Oxidized Guanine Nucleotide and ADP-sugar by Human NUDT5 Protein. " J. Biochem., 149, 731-738

Nishi, K., Ono, T., Nakamura, T., Fukunaga, N., Izumi, M., Watanabe, H., Suenaga, A., Maruyama, T., Yamagata, Y., Curry, S. & Otagiri, M. (2011) "Structural Insights into Differences in Drug-binding Selectivity between Two Forms of Human a1-Acid Glycoprotein Genetic Variants, the A and F1*S Forms." J. Biol. Chem., 286, 14427-14434

2010年

Mukai Y., Nakamura T., Yoshikawa M., Yoshioka Y., Tsunoda S., Nakagawa S., Yamagata Y. and Tsutsumi Y. (2010) "Solution of the Structure of the TNF-TNFR2 Complex." Science Signaling, 3, ra83-92

Miyata M, Sato T, Kugimiya M. Sho M, Nakamura T.; Ikemizu S, Chirifu M. Mizuguchi M, Nabeshima Y, Suwa Y, Morioka H, Arimori T, Suico M. A, Shuto T, Sako Y, Momohara M, Koga T,. Morino-Koga S, Yamagata Y and Kai H, (2010) "The crystal structure of the green tea polyphenol(-)-epigallocatechingallate (EGCG)-transthyretin complex reveals a novel binding site distinct from the thyroxine binding site." Biochemistry 49, 6104-6114

Yamaguchi Y, Takashio N, Wachino J, Yamagata Y., Arakawa Y, Matsuda K, Kurosaki H. (2010) "Structure of metallo-beta-lactamase IND-7 from a Chryseobacterium indologenes clinical isolate at 1.65-A resolution." J Biochem., 147, 905-15

Miyata M., Sato T., Mizuguchi M., Nakamura T., Ikemizu S., Nabeshima Y., Susuki S., Suwa Y., Morioka H., Ando Y., Suico MA., Shuto T., Koga T., Yamagata Y., and Kai H. (2010) "Role of the glutamic acid 54 residue in transthyretin stability and thyroxine binding." Biochemistry, 49, 114-123

Nakamura T., Meshitsuka S., Kitagawa S., Abe N., Yamada J., Ishino T., Nakano H., Tsuzuki T., Doi T., Kobayashi Y., Fujii S., Sekiguchi M., and Yamagata Y. (2010) "Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base." J Biol Chem., 285, 444-452

2009年

Kamiya H., Hori M., Arimori T., Sekiguchi M., Yamagata Y. and Harashima H. (2009) "NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity DNA Repair." DNA Repair, 10, 1250-1254

Mukai Y., Nakamura T., Yoshioka Y., Shibata H., Abe Y., Nomura T., Taniai M., Ohta T., Nakagawa S., Tsunoda S., Kamada H., Yamagata Y., and Tsutsumi Y. (2009) "Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF: useful information for designing artificial proteo-antagonists" J. Biochemistry (Tokyo), 146, 162-172

Yamaguchi Y., Sato G., Yamagata Y., Doi Y., Wachino J., Arakawa Y., Matsuda K., and Kurosaki H. (2009) "Structure of AmpC b-lactamase (AmpCD) from an Escherichia coli clinical isolate with a tripeptide deletion (Gly286-Ser287-Asp288) in the H10 helix." Acta Cryst., F65, 540-543

Mukai Y., Nakamura T., Yoshioka Y., Tsunoda S., Kamada H., Nakagawa S., Yamagata Y., and Tsutsumi Y. (2009) "Crystallization and preliminary X-ray analysis of the tumor necrosis factor a (TNF) tumor necrosis factor receptor type 2 (TNFR2) complex." Acta Cryst., F65, 295-298

Mukai Y., Shibata H., Nakamura T., Yoshioka Y., Abe Y., Nomura T., Ikemizu S., Nakagawa S., Tsunoda S., Kamada H., Yamagata Y., and Y. Tsutsumi (2009) "Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant." J. Mol. Biol., 381, 1221-1229

2008年

Tsuji Y., Watanabe K., Araki K., Shinohara M., Yamagata Y., Tsurimoto T., Hanaoka F., Yamamura K., Yamaizumi M., Tateishi S. (2008) "Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks." Genes to Cells, 13, 343-354

Suwa Y., Nakamura T., Toma S., Ikemizu S., Kai H., Yamagata Y. (2008) "Preparation, crystallization and preliminary X-ray diffraction analysis of the DNA binding domain of the Ets transcription factor in complex with target DNA." Acta Cryst., F64, 171-174

Shibata H., Yoshioka Y., Ohkawa A., Minowa K., Mukai Y., Abe Y., Taniai M., Nomura T., Kayamuro H., Nabeshi H., Sugita T., Imai S., Nagano K., Yoshikawa T., Fujita T., Nakagawa S., Yamamoto A., Ohta T., Hayakawa T., Mayumi T., Vandenabeele P., Aggarwal BB., Nakamura T., Yamagata Y., Tsunoda S., Kamada H., Tsutsumi Y. (2008) "Creation and X-ray structure analysis of the tumor necrosis factor receptor-1 selective mutant of a TNFa antagonist. " J. Biol. Chem., 283, 998-1007

2007年

Yamaguchi Y., Jin W., Matsunaga K., Ikemizu S., Yamagata Y., Wachino J., Shibata N., Arakawa Y., Kurosaki H.(2007) "Crystallographic Investigation of the Inhibition Mode of a VIM-2 Metallo-b-lactamase from Pseudomonas aeruginosa by a Mercaptocarboxylate Inhibitor."  J. Med. Chem., 50, 6647-6653 (2007)

Chirifu M., Hayashi C., Nakamura T., Toma S., Shuto T., Kai, H., Yamagata Y., Davis S.J., Ikemizu S.(2007) "Crystal structure of the IL-15−IL-15Ra complex, a cytokine-receptor unit presented in trans."  Nature Immunol., 8, 1001-1007 (2007)

2006年

Nakamura T., Kitaguchi Y., Miyazawa M., Kamiya H., Toma S., Ikemizu S., Shirakawa M., Nakabeppu Y., Yamagata Y. (2006) "Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP" Acta Cryst., F62, 1283-1285

46) Kurosaki H., Yamaguchi Y., Yasuzawa H., Jin W., Yamagata Y., Arakawa Y. (2006) "Probing, inhibition, and crystallographical characterization of metallo-b-lactamase (IMP-1) with fluorescent agents containing dansyl and thiol groups" Chem. Med. Chem. 1, 969-972

J. K. Kaushik, S. Iimura, K. Ogasahara, Y. Yamagata, S. Segawa, and K. Yutani  (2006) "Completely-buried, non-ion-paired glutamic acid contributes favorably to the conformational stability of pyrrolidone carboxyl peptidases from hyperthermophiles" Biochemistry, 45 7100-7112

2005年

S. J. Lee, K. Ogasahara, J. Ma, K. Nishio, M. Ishida, Y. Yamagata, T. Tsukihara, and K. Yutani  (2005) "Conformational Changes in the Tryptophan Synthase from a Hyperthermophile upon a2b2 Complex Formation: Crystal Structure of the Complex" Biochemistry 44, 11417-11427

T. Ishibashi, H. Hayakawa, R. Ito, M. Miyazawa, Y. Yamagata, and M. Sekiguchi (2005) "Mammalian enzymes for preventing transcriptional errors caused by oxidative damage" Nucleic Acids Res. 33, 3779-3784

H. Kurosaki, Y. Yamaguchi, T. Higashi, K. Soga, S. Matsueda, H. Yumoto, S. Misumi, Y. Yamagata, Y. Arakawa, and M. Goto "Irreversible inhibition of metallo-b-lactamase (IMP-1) by 3-(3- mercaptopropionylsulfanyl)propionic acid pentafluorophenyl ester" Angew Chem Int Ed. 44, 3861-3864 (2005)

Y. Yamaguchi, T. Kuroki, H. Yasuzawa, T. Higashi, W. Jin, A. Kawanami, Y. Yamagata, Y. Arakawa, M. Goto, and H. Kurosaki  (2005) "Probing the role of Asp120(81) of metallo-b-lactamase (IMP-1) by site-directed mutagenesis, kinetic studies, and X-ray crystallography" J Biol Chem. 280, 20824-20832

Tsunaka, Y., Takano, K., Matsumura, H., Yamagata, Y. and Kanaya, S. (2005) "Identification of single Mn2+ binding sites required for activation of the mutant proteins of E. coli RNase HI at Glu48 and/or Asp134 by X-ray crystallography " J. Mol. Biol., 345, 1171-1183.

2004年

Shibata, H., Yoshioka, Y., Ikemizu, S., Kobayashi, K., Yamamoto, Y., Mukai, Y., Okamoto, T., Taniai, M., Kawamura, M., Abe, Y., Nakagawa, S., Nagata, S.,Yamagata, Y., Mayumi, T. and Tsutsumi, Y. (2004) "Functionalization of TNF-alpha using phage display technique and PEGylation improves its antitumor therapeutic window" Clinical Cancer Res., 10, 8293-8300.

Chaya, N., Terauchi, K., Yamagata, Y., Kinjo, J., and Okabe, H. (2004) "Antiproferative Constituents on Plants 14. Coumarins and Acridone Alkaloids from Boenninghausenia japonica Nakai" Biol. Pharm. Bull., 27, 1312-1316.

T. Nakamura, T. Doi, M. Sekiguchi and Y. Yamagata (2004) "Crystallization and preliminary X-ray analysis of Escherichia coli MutT in binary and ternary complex forms" Acta Cryst., D60, 1641-1643.

Mishima M, Sakai Y, Itoh N, Kamiya H, Furuichi M, Takahashi M, Yamagata Y, Iwai S, Nakabeppu Y, Shirakawa M (2004) "Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates" J. Biol. Chem., 279, 33806-33815.

Y. Hioki, K. Ogasahara, S. Lee, J. Ma, M. Ishida, Y. Yamagata, Y. Matsuura, M. Ota, M. Ikeguchi, S. Kuramitsu and K. Yutani (2004) "The Crystal Structure of the Tryptophan Synthase β Subunit from the Hyperthermophile, Pyrococcus furiosus : Investigation of Stabilization Factors" Eur. J. Biochem., 271, 2624-2635.

Yoshioka Y., Tsutsumi Y., Ikemizu S., Yamamoto Y., Shibata H., Nishibata T., Mukai Y., Okamoto T., Taniai M., Shimizu T., Kawamura M., Abe Y., Nakagawa S., Nagata S., Yamagata Y., Mayumi T. (2004) Optimal site-specific PEGylation of mutant TNF-alpha improves its antitumor potency" Biochem Biophys Res Commun. 315, 808-814.

2003年

H. Takatsuna, H. Kato, J. Gohda, T. Akiyama, A. Moriya, Y. Okamoto, Y. Yamagata, M. Otsuka, K. Umezawa, K. Semba, and Jun-ichiro (2003) "Identification of TIFA as an adapter protein that links TRAF6 to IRAK-1 in IL-1 receptor signaling" J. Biol. Chem. 278, 12144 - 12150.

H. Nakano, T. Yoshida, S. Uchiyama, M. Kawachi, H. Matsuo, T. Kato, A. Ohshima, Y. Yamaichi, T. Honda, H. Kato, Y. Yamagata, T. Ohkubo, and Y. Kobayashi (2003) "Structure and Binding Mode of a Ribosome Recycling Factor (RRF) from Mesophilic Bacterium" J. Biol. Chem. 278, 3427-3436.

K. Takano, Y. Yamagata and K. Yutani (2003) "Buried Water Molecules Contribute to the Conformational Stability of a Protein" Protein Eng. 16, 5-9.

2002年

S. Goda, K. Takano, Y. Yamagata, S. Maki, K. Namba and K. Yutani (2002) "Elongation in a b-Structure Promotes Amyloid-like Fibril Formation of Human Lysozyme" J. Biochem. 132, 655-661.

J. Funahashi, K. Takano, Y. Yamagata and K. Yutani (2002) "Positive Contribution of Hydration Structure on the Surface of Human Lysozyme to the Conformational Stability" J. Biol. Chem. 277, 21792-21800.

Y. Hari, S. Obika, M. Sakaki, K. Morio, Y. Yamagata, and T. Imanishia (2002) "Effective Synthesis of C-nucleosides with 2 ',4 '-BNA Modification" TETRAHEDRON, 58, 3051-3063.

H. Nakano, S. Uchiyama, T. Yoshida, T. Ohkubo, H. Kato, Y. Yamagata and Y. Kobayashi (2002) "Crystallization and Preliminary X-ray Crystallographic Studies of a Mutant of Ribosome Recycling Factor from Escherichia coli, Arg132Gly" Acta Cryst. D58, 124-126

2001年

K. Takano, Y. Yamagata and K. Yutani (2001) "Role of Amino Acid Residues in Left-handed Helical Conformation for the Conformational Stability of a Protein" Proteins 45, 274-280

K. Takano, Y. Yamagata and K. Yutani (2001) "Contribution of Polar Groups in the Interior of a Protein to the Conformational Stability" Biochemistry 40, 4853 - 4858

K. Takano, Y. Yamagata and K. Yutani (2001) "Role of Non- glycine Residues in Left-handed Helical Conformation for the Conformational Stability of Human Lysozyme" Proteins 44, 233-243

Y. Yamagata, K. Ogasahara, Y. Hioki, S.J. Lee, A. Nakagawa, H. Nakamura, M. Ishida, S. Kuramitsu and K. Yutani (2001) "Entropic Stabilization of the Tryptophan Synthase a-subunit from a Hyperthermophile, Pyrococcus furiosus: X-ray Analysis and Calorimetry." J. Biol. Chem. 276, 11062-11071

2000年

J. Funahashi, K. Takano, Y. Yamagata and K. Yutani (2000) "Role of Surface Hydrophobic Residues in the Conformational Stability of Human Lysozyme at Three Different Positions" Biochemistry 39, 14448-14456

K. Takano, K. Tsuchimori, Y. Yamagata and K. Yutani (2000) "Contribution of Salt Bridges near the Surface of a Protein to the Conformational Stability" Biochemistry 39, 12375-12381

K. Takano, Y. Yamagata and Katsuhide Yutani (2000) "Role of Amino Acid Residues at Turns in the Conformational Stability and Folding of Human Lysozyme" Biochemistry 39, 8655-8665

S. Goda, K. Takano, Y. Yamagata, Y. Katakura and K. Yutani (2000) "Effect of the Extra N-terminal Residues on the Stability and Folding of Human Lysozyme Expressed in Pichia pastoris" Protein Eng. 13, 299-307

S. Goda, K. Takano, Y. Yamagata, R. Nagata, H. Akutsu, S. Maki, K. Namba and K. Yutani (2000) "Amyloid Protofilament Formation of Hen Egg Lysozyme in Highly Concentrated Ethanol Solution" Protein Science 9, 369-375

K. Yutani, G. Takayama, S. Goda, Y. Yamagata, S. Maki, K. Namba, S. Tsunasawa, and K. Ogasahara "The Process of Amyloid-like Fibril Formation by Methionine Aminopeptidase from a Hyperthermophile, Pyrococcus furiosus" (2000) Biochemistry 39, 2769-2777

1999年

K. Takano, K. Tsuchimori, Y. Yamagata and K. Yutani (1999) "Effect of Foreign N-terminal Residues on the Conformational Stability of Human Lysozyme" Eur. J. Biochem. 266, 675-682

J. Funahashi, K. Takano, Y. Yamagata and K. Yutani (1999) "Contribution of Amino Acid Substitutions at Two Different Interior Positions to the Stability of Human Lysozyme" Protein Eng. 12, 841-850

K. Takano, Y. Yamagata, J. Funahashi, Y. Hioki, S. Kuramitsu and K. Yutani (1999) "Contribution of Intra- and Intermolecular Hydrogen Bonds to the Conformational Stability of Human Lysozyme" Biochemistry 38, 12698-12708

K. Takano, M. Ota, K. Ogasahara, Y. Yamagata, K. Nishikawa and K. Yutani (1999) "Experimental Verification of the 'Stability Profile of Mutant Protein' (SPMP) Data Using Mutant Human Lysozymes" Protein Eng. 12, 663-672

K. Takano, Y. Yamagata, M. Kubota, J. Funahashi, S. Fujii and K. Yutani (1999) "Contribution of Hydrogen Bonds to the Conformational Stability of Human Lysozyme: Calorimetry and X-ray Analysis of Six Serine -> Alanine Mutants" Biochemistry 38, 6623-6629

1998年

T. Kaiya, T. Saga, Y. Yamagata and K. Kohda (1998) "Reaction of 7- and 9-Aminoadenines with 2,4-Pentaedione. Formation of New Ring Systems, Pyridazino[6,1-f]purine and Pyridazino[1,6-e]purine" Bioorg. Med. Chem. Lett. 8, 2197-2202

K. Takano, Y. Yamagata and K. Yutani (1998) "A General Rule for the Relationship between Hydrophobic Effect and Conformational Stability of a Protein: Stability and Structure of a Series of Hydrophobic Mutants of Human Lysozyme" J. Mol. Biol. 280, 749-761

Y. Yamagata, M. Kubota, Y. Sumikawa, J. Funahashi, K. Takano, S. Fujii and K. Yutani (1998) "Contribution of Hydrogen Bonds to the Conformational Stability of Human Lysozyme: Calorimetry and X-ray Analysis of Six Tyrosine -> Phenylalanine Mutants" Biochemistry 37, 9355-9362

1997年

K. Takano, Y. Yamagata, S. Fujii and K. Yutani (1997) "Contribution of the Hydrophobic Effect to the Stability of Human Lysozyme:Calorimetric Studies and X-ray Structural Analyses of the Nine Valine to Alanine Mutants" Biochemistry 36, 688-698

K. Takano, J. Funahashi, Y. Yamagata, S. Fujii and K. Yutani (1997) "Contribution of Water Molecules in the Interior of a Protein to the Conformational Stability" J. Mol. Biol. 274, 132-142

1996年

T. Katagi, H. Kataoka, Y. Konishi, Y. Takata, S. Kitano, M. Yamaki, T. Inoi, K. Yamamoto, S. Yamamoto and Y. Yamagata (1996) "Syntheses and Anti-inflammatory Activities of O-Acyloximes" Chem. Pharm. Bull. 44, 145-149

L. Bai, M. Yamaki, Y. Yamagata and S. Takagi (1996) "Shanciol, A Dihydrophenanthropyran from Pleione bulbocodioides" Phytochem. 41, 625-628

S. Asano, K. Itano, Y. Yamagata and K. Kohda (1996) "Reaction of 9- Substituted 1-Aminoadenine with Hydrazine" J. Heterocyclic Chem. 33, 1115-1121

N. Nishizono, N. Koike, Y. Yamagata, S. Fujii and A. Matsuda (1996) "Nucleosides and Nucleotides. 159. Synthesis of Thietane Nucleosides Via the Pummerer Reaction as a Key Step" Tetrahedron Lett. 37, 7569-7572

J. Funahashi, K. Takano, K. Ogasahara, Y. Yamagata and K. Yutani (1996) "The Structure, Stability, and Folding Process of Amyloidogenic Mutant Human Lysozyme" J. Biochem. 120, 1216-1223 (1996)

Y. Yamagata, M. Kato, K. Odawara, Y. Tokuno, Y. Nakashima, N. Matsushima, K. Yasumura, K. Tomita, K. Ihara, Y. Fujii, Y. Nakabeppu, M. Sekiguchi and S. Fujii (1996) "Three-Dimensional Structure of a DNA Repair Enzyme, 3-Methyladenine DNA Glycosylase II, from Escherichia coli" Cell 86, 311-319


総説、その他

2012−2015年

Nakamura T, Mukai Y., Tsutsumi Y., Yamagata Y. "Structural Basis for Signal Initiation by TNF and TNFR." Protein Modifications in Pathogenic Dysregulation of Signaling, (J. Inoue, & M. Takekawa, eds), Springer, pp127-141 (2015)

山縣ゆり子、"15 構造生物学の歴史と進展" ファルマシア 50, 393−397 (2014) 

山縣ゆり子、"ゲノム安定性維持に働くタンパク質〜DNA修複・複製酵素" 日本の結晶学II 〜輝かしき発展〜  日本結晶学会編 (2014)

中村照也、山縣ゆり子、Wei Yang、"DNAポリメラーゼηによるリン酸ジエステル結合の形成過程の観察" 生物物理  53, 254−257(2013)

Nakamura T, Zhao Y, Yamagata Y, Hua YJ, Yang W. "Mechanism of the nucleotidyl-transfer reaction in DNA polymerase revealed by time-resolved protein crystallography." Biophysics, 9, 31-36 (2013) [J-STAGE]

中村照也、山縣ゆり子、Wei Yang、"時分割タンパク質結晶学によるDNA ポリメラーゼη のヌクレオチド転移反応の可視化"日本結晶学会 55, 42−46(2013) 

中村照也、山縣ゆり子、Wei Yang、"DNAポリメラーゼηによるリン酸ジエステル結合の形成の過程を観察する"ライフサイエンス新着論文レビュー、[First Author’s, 2012] 

2009−2011年  

有森貴夫、山縣ゆり子、"突然変異抑制酵素NUDT5の幅広い基質特異性発現機構" 福岡医学雑誌 102, No.11, 303-312 (2011)

山縣ゆり子、"14章 分子分光学" 薬学物理化学演習第3版 小野行雄編、 廣川書店、185-195 & 327-338 (2011)

山縣ゆり子、"14章 分子分光学" 薬学物理化学第5版 小野行雄編、 廣川書店、305-321(2010)

中村照也、山縣ゆり子、"2章 X線結晶構造解析法の展開" 薬学分析科学の最前線、日本薬学会物理系薬学部会・分析化学担当教員会議編、 じほう、29-33(2009)

2004−2008年

中村照也、山縣ゆり子、"アルツハイマー病治療薬塩酸ドネペジルによるアセチルコリンエステラーゼの阻害機構" 医薬ジャーナル, 43, No.5, 5-14 (2007)

入佐正幸、神田大輔、山縣ゆり子、"支部だより 九州支部からのたより" 生物物理 47, 408-409 (2007)

山縣ゆり子、"10章 タンパク質の構造と機能" スタンダード薬学シリーズ4「生物系薬学II. 生命をミクロに理解する」 日本薬学会編、 東京化学同人、128-141(2005)

山縣ゆり子、"7章SBO20 鍵と鍵穴モデルおよび誘導適応モデルについて、具体例をあげて説明できる" スタンダード薬学シリーズ2「物理系薬学III. 生対分子・化学物質の構造決定」 日本薬学会編、 東京化学同人、110-115(2005)

山縣ゆり子、"タンパク質は遺伝子の傷をいかに治すか" タンパク質のかたちから生命のなぞを解く (田之倉優編)、(株)クバクロ、29−36(2005)

山縣ゆり子、"巻頭言 待つ度量" 生物物理 44, 197 (2004) 

1996−2003年

加藤昭夫、内海成、内海俊彦、河田康志、山縣ゆり子、山岸明彦、山田守、吉川正明、(2003)タンパク質工学〜生命科学系分野のために〜 医学出版

山縣ゆり子 (2003) "タンパク質の立体構造から生命の仕組みを探る" 日本の科学者 38, 198−203

山縣ゆり子 (2002)"DNA修復に関連する酵素の立体構造と機能" 酵素工学ニュース 48, 5-11

山縣ゆり子 (2002)"タンパク質の立体構造から如何に機能を汲み出すか ―アルキル化DNA修復酵素を例に" 長崎大学機器分析センター年報 16,33−37

山縣ゆり子 (2001) "DNAグリコシラーゼスーパーファミリーの3次元構造に基づく機能解明"蛋白質核酸酵素 46, 増刊「DNA修復ネットワークとその破綻の分子病態」976-985

山縣ゆり子 (2001) "アミロイド線維形成機構解明の進展" ファルマシア 37, 114-118

Y. Yamagata and H. Nakano (1998) "Structure-based Design of a DNA Repair Enzyme with Altered Catalytic Activity" Proceedings of the 41st Seminar on Science and Technology "Crystallography" , 179-185

山縣ゆり子 (1998) "DNAグリコシラーゼスーパーファミリーの3次元構造と機能" 構造生物 4(3), 40-51

山縣ゆり子 (1997) "大腸菌由来DNA修復酵素3ーメチルアデニンDNAグリコシラーゼの構造と 機能" 日本結晶学会誌 39, 303-308

山縣ゆり子 (1997) "3ーメチルアデニンDNAグリコシラーゼ" Molecular Medicine 臨時増刊号「 ノックアウトマウス・データブック」 34, 322-323

山縣ゆり子 (1997) " 塩基除去修復に働くDNAグリコシラーゼの立体構造" 蛋白質工学基礎研究センターだより 18, 18-24


研究内容 研究成果 研究業績 略歴 TopPage スタッフのページに戻る