中村照也のページ

ホーム　　研究　　メンバー　　発表論文等　　熊本大学薬学部/大学院薬学教育部　　熊本大学

中村　照也

熊本大学大学院生命科学研究部（薬学系）独立准教授

E-mail: tnaka [at] gpo.kumamoto-u.ac.jp

略歴

2021年〜熊本大学大学院生命科学研究部（薬学系）准教授（テニュア取得）

2016年熊本大学大学院先導機構　テニュアトラック准教授

文部科学省　卓越研究員

2011年米国国立衛生研究所客員研究員

2010年博士（薬学）（熊本大学）

2010年熊本大学大学院生命科学研究部（薬学系）助教

2007年熊本大学大学院医学薬学研究部　助教

2006年熊本大学大学院医学薬学研究部　助手

2005年日本学術振興会特別研究員DC2

2004年熊本大学大学院薬学教育部博士後期課程

2003年協和発酵工業株式会社　医薬総合研究所　研究員

2003年大阪大学大学院薬学研究科博士前期課程修了

2001年大阪大学薬学部薬学科卒業

受賞

2013年国立大学法人熊本大学研究業績表彰

2013年日本結晶学会進歩賞

2012年日本生物物理学会若手奨励賞

資格

2001年薬剤師

発表論文等

中村照也

"自然免疫にかかわるNF-κBシグナルの抑制機構の構造学的基盤"

日本結晶学会誌, 66, 169-170 (2024) [Web]

Nakamura Y, Watanabe H, Nakamura T, Chirifu M, Ishiodori K, Imafuku T, Maeda H, Kobashigawa Y, Morioka H, Maruyama T.

"Contribution of Phe112, Ser114, and Tyr115 to Drug-Binding Selectivity in the A Variant of α1-Acid Glycoprotein."

Mol Pharm., 21, 4038-4046 (2024) [PubMed]

Oniki K, Ohura K, Endo M, Akatwijuka D, Matsumoto E, Nakamura T, Ogata Y, Yoshida M, Harada-Shiba M, Saruwatari J, Ogura M, Imai T

"The Association of the Cholesterol Efflux Capacity with the Paraoxonase 1 Q192R Genotype and the Paraoxonase Activity."

J. Atheroscler. Thromb., in press [PubMed]

Nakamura T*, Ohyama C, Sakamoto M, Toma T, Tateishi H, Matsuo M, Chirifu M, Ikemizu S, Morioka H, Fujita M, Inoue J, Yamagata Y

"TIFAB regulates the TIFA-TRAF6 signaling pathway involved in innate immunity by forming a heterodimer complex with TIFA."

Proc. Natl. Acad. Sci. U. S. A., 121, e2318794121 (2024) [PubMed]

中村照也

"動的構造解析による酵素反応機構の解明"

DOJIN NEWS, 187, 11-13 (2023) [Web]

Nakamura T*

"Time-resolved X-ray crystallography of enzymatic reaction that degrades a mutagenic nucleotide."

SPring-8/SACLA Research Frontiers 2022, 28-29 (2023) [Web]

Yasuda K, Maeda H, Kinoshita R, Minayoshi Y, Mizuta Y, Nakamura Y, Imoto S, Nishi K, Yamasaki K, Sakuragi M, Nakamura T, Ikeda-Imafuku M, Iwao Y, Ishima Y, Ishida T, Iwakiri Y, Otagiri M, Watanabe H, Maruyama T

"Encapsulation of an Antioxidant in Redox-Sensitive Self-Assembled Albumin Nanoparticles for the Treatment of Hepatitis."

ACS Nano, 17, 16668-16681 (2023) [PubMed]

Utatsu K, Motoyama K, Nakamura T, Onodera R, Higashi T

"Tannic acid-based sustained-release system for protein drugs."

Int. J. Pharm., 643, 123229 (2023) [PubMed]

Nakamura T*#, Koga-Ogawa Y#, Fujimiya K, Chirifu M, Goto M, Ikemizu S, Nakabeppu Y, Yamagata Y

"Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition."

FEBS Letters, 593, 1770-1778 (2023) [PubMed]

Nakamura T* and Yamagata Y

"Visualization of mutagenic nucleotide processing by Escherichia coli MutT, a Nudix hydrolase."

Proc. Natl. Acad. Sci. U. S. A., 119, e2203118119 (2022) [PubMed]

Taharabaru T, Kihara T, Onodera R, Koga T, Higashi K, Moribe K, Nakamura T, Motoyama K, Higashi T

"Polyrotaxane-based Multi-step Transformable Materials for the Delivery of Cas9 Ribonucleoprotein."

Applied Materials Today, 27, 101488 (2022) [Web]

El-Desoky AHH, Eguchi K, Kishimoto N, Asano T, Kato H, Hitora Y, Kotani S, Nakamura T, Tsuchiya S, Kawahara T, Watanabe M, Wada M, Nakajima M, Watanabe T, Misumi S, Tsukamoto S

"Isolation, Synthesis, and Structure-Activity Relationship Study on Daphnane and Tigliane Diterpenes as HIV Latency-Reversing Agents."

J. Med. Chem., 65, 3460-3472 (2022) [PubMed]

Mizuta Y, Maeda H, Ishima Y, Minayoshi Y, Ichimizu S, Kinoshita R, Hirata K, Nakamura T, Saruwatari J, Arima H, Watanabe H, Otagiri M, Maruyama T

"A mannosylated, PEGylated Albumin as a drug delivery system for the treatment of Cancer Stroma Cells."

Advanced Functional Materials, 31, 2104136 (2021) [Web]

Kobashigawa Y, Ohara T, Morita K, Toyota Y, Nakamura T, Kotani S, Arimori T, Yamauchi S, Liu C, Kitazaki M, Wakeyama-Miyazaki Y, Suwa Y, Uchida-Kamekura M, Fukuda N, Sato T, Nakajima M, Takagi J, Yamagata Y, Morioka H

"Molecular recognition of a single-chain Fv antibody specific for GA-pyridine, an advanced glycation end-product (AGE), elucidated using biophysical techniques and synthetic antigen analogues."

J. Biochemistry, 170, 379-387 (2021) [PubMed]

Nakamura T*, Okabe K, Hirayama S, Chirifu M, Ikemizu S, Morioka H, Nakabeppu Y, Yamagata Y

"Structure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer."

Nucleic Acids Research, 49, 7154-7163 (2021) [PubMed]

中村照也

がんに関わる酵素の高分解能X線結晶構造解析 –水素原子レベルでの酵素反応機構・阻害剤結合機構の解明を目指して–

JAXA 高品質タンパク質結晶生成実験宇宙実験の成果 (2021) [Web] [Web2]

Mustofa MK, Tanoue Y, Chirifu M, Shimasaki T, Tateishi C, Nakamura T, Tateishi S

"RAD18 mediates DNA double-strand break-induced ubiquitination of chromatin protein."

J. Biochemistry, 170, 33-40 (2021) [PubMed]

Yokoyama R, Taharabaru T, Nishida T, Ohno Y, Maeda Y, Sato M, Ishikura K, Yanagihara K, Takagi H, Nakamura T, Ito S, Ohtsuki S, Arima H, Onodera R, Higashi T, Motoyama K

"Lactose-appended β-cyclodextrin as an effective nanocarrier for brain delivery."

J. Control. Release, 328, 722-735 (2020) [PubMed]

Nakamura T, Nakamura T, Amano M, Miyakawa T, Yamagata Y, Matsuoka M, Nakata H

"A conformational escape reaction of HIV-1 against an allosteric integrase inhibitor."

J. Virol., 94, e00486-20 (2020) [PubMed]

Nakamura T*, Hashikawa C, Okabe K, Yokote Y, Chirifu M, Toma-Fukai S, Nakamura N, Matsuo M, Kamikariya M, Okamoto Y, Gohda J, Akiyama T, Semba K, Ikemizu S, Otsuka M, Inoue J, Yamagata Y

"Structural analysis of TIFA: Insight into TIFA-dependent signal transduction in innate immunity."

Scientific Reports, 10, 5152 (2020) [PubMed]

Nakamura T*, Hirata K, Fujimiya K, Chirifu M, Arimori T, Tamada T, Ikemizu S, Yamagata Y

"X-ray Structure Analysis of Human Oxidized Nucleotide Hydrolase MTH1 using Crystals Obtained under Microgravity."

Int. J. Microgravity Sci. Appl., 36, 360103 (2019) [Web]

Fukuda M, Yoshizawa T, Karim MF, Sobuz SU, Korogi W, Kobayasi D, Okanishi H, Tasaki M, Ono K, Sawa T, Sato Y, Chirifu M, Masuda T, Nakamura T, Tanoue H, Nakashima K, Kobashigawa Y, Morioka H, Bober E, Ohtsuki S, Yamagata Y, Ando Y, Oike Y, Araki N, Takeda S, Mizuta H, Yamagata K

"SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix."

Nature Commun., 9, 2833 (2018) [PubMed]

Hira D, Kitamura R, Nakamura T, Yamagata Y, Furukawa K, Fujii T

"Anammox Organism KSU-1 Expresses a Novel His/DOPA Ligated Cytochrome c."

J. Mol. Biol., 430, 1189-1200 (2018) [PubMed]

Waz S#, Nakamura T#, Hirata K, Koga-Ogawa Y, Chirifu M, Arimori T, Tamada T, Ikemizu S, Nakabeppu Y, Yamagata Y

"Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity."

J. Biol. Chem., 292, 2785-2794 (2017) [PubMed]

Aoki M, Hayashi H, Yedidi RS, Martyr CD, Takamatsu Y, Aoki-Ogata H, Nakamura T, Nakata H, Das D, Yamagata Y, Ghosh AK, Mitsuya H

"C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir."

J. Virol., 90, 2180-2194 (2016) [PubMed]

Nakamura T*, Mukai Y, Tsutsumi Y, Yamagata Y

"Structural Basis for Signal Initiation by TNF and TNFR."

In: Inoue J, Takekawa M (eds). Protein Modifications in Pathogenic Dysregulation of Signaling, Springer Tokyo, pp.127-141 (2015) [Web]

中村照也

"DNA損傷修復に働く酸化ヌクレオチド分解酵素MutTとDNAポリメラーゼηの反応機構の解明"

日本結晶学会誌, 56, 123-128 (2014) [Web]

中村照也*, 山縣ゆり子, Wei YANG

"DNAポリメラーゼηによるリン酸ジエステル結合の形成過程の観察"

生物物理, 53, 254-257 (2013) [Web]

Nakamura T*, Zhao Y, Yamagata Y, Hua YJ, Yang W

"Mechanism of the nucleotidyl-transfer reaction in DNA polymerase revealed by time-resolved protein crystallography."

Biophysics, 9, 31-36 (2013) [PubMed]

Obayashi K, Tasaki M, Jono H, Ueda M, Shinriki S, Misumi Y, Yamashita T, Oshima T, Nakamura T, Ikemizu S, Anan I, Suhr O, Ando Y

"Impact of antibodies against amyloidogenic transthyretin (ATTR) on phenotypes of patients with familial amyloidotic polyneuropathy (FAP) ATTR Valine30Methionine."

Clin. Chim. Acta, 419, 127-131 (2013) [PubMed]

中村照也*, 山縣ゆり子, Wei YANG

"時分割タンパク質結晶学によるDNAポリメラーゼηのヌクレオチド転移反応の可視化"

日本結晶学会誌, 55, 42-46 (2013) [Web]

Koga Y, Inazato M, Nakamura T, Hashikawa C, Chirifu M, Michi A, Yamashita T, Toma S, Kuniyasu A, Ikemizu S, Nakabeppu Y, Yamagata Y

"Crystallization and preliminary X-ray analysis of human MTH1 with a homogeneous N-terminus."

Acta Cryst., F69, 45-48 (2013) [PubMed]

中村照也*, 山縣ゆり子, Wei YANG

"DNAポリメラーゼηによるリン酸ジエステル結合の形成の過程を観察する"

ライフサイエンス新着論文レビュー　First Author's (2012) [Web]

Nakamura T, Zhao Y, Yamagata Y, Hua YJ, Yang W

"Watching DNA polymerase η make a phosphodiester bond."

Nature, 487, 196-201 (2012) [PubMed]

Arimori T, Tamaoki H, Nakamura T, Kamiya H, Ikemizu S, Takagi Y, Ishibashi T, Harashima H, Sekiguchi M, Yamagata Y

"Diverse Substrate Recognition and Hydrolysis Mechanisms of Human NUDT5."

Nucleic Acids Research, 39, 8972-8983 (2011) [PubMed]

Nishi K, Ono T, Nakamura T, Fukunaga N, Izumi M, Watanabe H, Suenaga A, Maruyama T, Yamagata Y, Curry S, Otagiri M

"Structural Insights into Differences in Drug-binding Selectivity between Two Forms of Human a1-Acid Glycoprotein Genetic Variants, the A and F1*S Forms."

J. Biol. Chem., 286, 14427-14434 (2011) [PubMed]

Mukai Y, Nakamura T, Yoshikawa M, Yoshioka Y, Tsunoda S, Nakagawa S, Yamagata Y, Tsutsumi Y

"Solution of the Structure of the TNF-TNFR2 Complex."

Science Signaling, 3, ra83 (2010) [PubMed]

Miyata M, Sato T, Kugimiya M, Sho M, Nakamura T, Ikemizu S, Chirifu M, Mizuguchi M, Nabeshima Y, Suwa Y, Morioka H, Arimori T, Suico MA, Shuto T, Sako Y, Momohara M, Koga T, Morino-Koga S, Yamagata Y, Kai H

"The Crystal Structure of the Green Tea Polyphenol (-)-Epigallocatechin Gallate-Transthyretin Complex Reveals a Novel Binding Site Distinct from the Thyroxine Binding Site."

Biochemistry, 49, 6104-6114 (2010) [PubMed]

Miyata M, Sato T, Mizuguchi M, Nakamura T, Ikemizu S, Nabeshima Y, Susuki S, Suwa Y, Morioka H, Ando Y, Suico MA, Shuto T, Koga T, Yamagata Y, Kai H

"Role of the glutamic acid 54 residue in transthyretin stability and thyroxine binding."

Biochemistry, 49, 114-123 (2010) [PubMed]

Nakamura T, Meshitsuka S, Kitagawa S, Abe N, Yamada J, Ishino T, Nakano H, Tsuzuki T, Doi T, Kobayashi Y, Fujii S, Sekiguchi M, Yamagata Y

"Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base."

J. Biol. Chem., 285, 444-452 (2010) [PubMed]

Mukai Y, Nakamura T, Yoshioka Y, Shibata H, Abe Y, Nomura T, Taniai M, Ohta T, Nakagawa S, Tsunoda S, Kamada H, Yamagata Y, Tsutsumi Y

"Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF: useful information for designing artificial proteo-antagonists."

J. Biochemistry, 146, 167-172 (2009) [PubMed]

中村照也, 山縣ゆり子

2章　X線結晶構造解析法の展開

薬学分析科学の最前線 日本薬学会物理系薬学部会･分析化学担当教員会議編, じほう, 29-33 (2009)

Mukai Y, Nakamura T, Yoshioka Y, Tsunoda S, Kamada H, Nakagawa S, Yamagata Y, Tsutsumi Y

"Crystallization and preliminary X-ray analysis of the tumour necrosis factor alpha-tumour necrosis factor receptor type 2 complex."

Acta Cryst., F65, 295-298 (2009) [PubMed]

Mukai Y, Shibata H, Nakamura T, Yoshioka Y, Abe Y, Nomura T, Ikemizu S, Nakagawa S, Tsunoda S, Kamada H, Yamagata Y, Tsutsumi Y

"Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant."

J. Mol. Biol., 385, 1221-1229 (2009) [PubMed]

Suwa Y, Nakamura T, Toma S, Ikemizu S, Kai H, Yamagata Y

"Preparation, crystallization and preliminary X-ray diffraction analysis of the DNA binding domain of the Ets transcription factor in complex with target DNA."

Acta Cryst., F64, 171-174 (2008) [PubMed]

Shibata H, Yoshioka Y, Ohkawa A, Minowa K, Mukai Y, Abe Y, Taniai M, Nomura T, Kayamuro H, Nabeshi H, Sugita T, Imai S, Nagano K, Yoshikawa T, Fujita T, Nakagawa S, Yamamoto A, Ohta T, Hayakawa T, Mayumi T, Vandenabeele P, Aggarwal BB, Nakamura T, Yamagata Y, Tsunoda S, Kamada H, Tsutsumi Y

"Creation and X-ray structure analysis of the tumor necrosis factor receptor-1 selective mutant of a tumor necrosis factor-alpha antagonist."

J. Biol. Chem., 283, 998-1007 (2008) [PubMed]

Chirifu M, Hayashi C, Nakamura T, Toma S, Shuto T, Kai H, Yamagata Y, Davis SJ, Ikemizu S

"Crystal structure of the IL-15−IL-15Ra complex, a cytokine-receptor unit presented in trans."

Nature Immunology, 8, 1001-1007 (2007) [PubMed]

中村照也, 山縣ゆり子

"分子構造から考える薬物の作用機序(4)アルツハイマー病治療薬塩酸ドネペジルによるアセチルコリンエステラーゼの阻害機構"

医薬ジャーナル, 43, 5-14 (2007)

Nakamura T, Kitaguchi Y, Miyazawa M, Kamiya H, Toma S, Ikemizu S, Shirakawa M, Nakabeppu Y, Yamagata Y

"Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP."

Acta Cryst., F62, 1283-1285 (2006) [PubMed]

Nakamura T, Doi T, Sekiguchi M, Yamagata Y

"Crystallization and preliminary X-ray analysis of Escherichia coli MutT in binary and ternary complex forms."

Acta Cryst., D60, 1641-1643 (2004) [PubMed]

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