We search new proteins (genes) that should be new
targets of medicine. For example, in order to induce
over-initiation of DNA replication in cancer cells, we
examine mechanism governing the regulation of DNA
replication. We also analyze stress genes by use of
DNAchip technique to established the clinical protocol
for stress-induced diseases.
And also, we are searching for new antitumor and
antiviral drugs produced by microorganisms.
Topoisomerases are known to be the target enzymes of
antitumor drugs. Topostatin and isoaurostatin having
novel structures are the antitumor drugs of new type
which do not give DNA damage unlike the conventional
antitumor drugs. Fattiviracins found as antiviral
agents are novel compounds effective for herpes, human
immunodeficiency and influenza virus. Fattiviracins
will be in clinical use for the treatment of viral
diseases. Now, we have tried to find more effective
antitumor and antivirus drugs by carrying out
syntheses of the structure analogues.

DNA replication, Cancer, Stress response, HSP, Folding
disease, microorganism, topoisomerase, inhibitor,
anticancer, antiviral drug