研究業績 publications

主要論文

• *Kashio M, Masubuchi S and Tominaga M (2022). *責任著者
  Protein kinase C-mediated phosphorylation of transient receptor potential melastatin type 2 Thr738 counteracts the effect of cytosolic Ca²⁺ and elevates the temperature threshold.
  J Physiol, 600(19):4287-4302. doi: 10.1113/JP283350
• Kashio M, Sokabe T, Shintaku K, Uematsu T, Fukuta N, Kobayashi N, Mori Y, Tominaga M (2012)
  Redox signal-mediated sensitization of Transient Receptor Potential Melastatin 2 (TRPM2) to temperature affects macrophage functions.
  Proc Natl Acad Sci U S A, 109(17):6745-50. DOI:10.1073/pnas.1114193109

論文

• Inoue K, Takenouchi S, Kida M, Kashio M, Tominaga M, Murata T.
  Transient receptor potential vanilloid 4 gene-deficiency attenuates the inhibitory effect of 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid on vascular permeability in mice.
  J Pharmacol Sci, 2025 Jan;157(1):35-38
• *Kashio M. *責任著者
  Thermosensitive TRPM2: the regulatory mechanisms of its temperature sensitivity and physiological functions.
  J Physiol Sci, 75(1):100008. Doi: 10.1016/j.jphyss.2025.100008
• *Kashio M. *責任著者
  Thermo-TRP regulation by endogenous factors and its physiological function at core body temperature.
  Physiol Rep, 13:e70164. doi: 10.14814/phy2.70164.

• ^#Kashio M, ^#Derouiche S, Yoshimoto RU, Sano K, Lei J, Kido MA and Tominaga M. ^#共同筆頭著者
  Involvement of TRPV4 in temperature-dependent perspiration in mice.
  eLife, Jul 4, 2024 doi.org/10.7554/eLife.92993.3 (version of record)
• Ujisawa T, Lei J, Kashio M, Tominaga M.
  Thermal gradient ring for analysis of temperature-dependent behaviors involving TRP channels in mice.
  J Physiol Sci, 74:9. doi: 10.1186/s12576-024-00903-w.

• Okada Y, Numata T, Sabirov RZ, Kashio M, Merzlyak PG, Sato-Numata K.
  Cell death induction and protection by activation of ubiquitously expressed anion/cation channels. Part 3: the roles and properties of TRPM2 and TRPM7.
  Front Cell Dev Biol, 11:1246955. doi: 10.3389/fcell.2023.1246955.
• *Kashio M and *Tominaga M. *責任著者
  Role of novel de novo gain-of-function TRPM3 mutations in a spectrum of neurodevelopmental disorders.
  Cell Calcium, 110:102704. doi: 10.1016/j.ceca.2023.102704.

• *Kashio M, Masubuchi S and Tominaga M. *責任著者
  Protein kinase C-mediated phosphorylation of transient receptor potential melastatin type 2 Thr738 counteracts the effect of cytosolic Ca²⁺ and elevates the temperature threshold.
  J Physiol, 600(19):4287-4302. doi: 10.1113/JP283350
• Nguyen THD, Chapman S, Kashio M, Saito C, Strom T, Mio Yasui M, Tominaga M.
  Single amino acids set apparent temperature thresholds for heat-evoked activation of mosquito transient receptor potential channel TRPA1.
  J Biol Chem, 298(9):102271. DOI: 10.1016/j.jbc.2022.102271
• Ujisawa T, Sasajima S, Kashio M, Tominaga M.
  Thermal gradient ring reveals different temperature-dependent behaviors in mice lacking thermosensitive TRP channels.
  J Physiol Sci, 72(11) DOI: 10.1186/s12576-022-00835-3.
• *Kashio M and *Tominaga M *責任著者
  TRP channels in thermosensation.
  Curr Opin Neurobiol, Jun 18;75:102591. doi: 10.1016/j.conb.2022.102591.

• Nishimoto R, Derouiche S, Eto K, Deveci A, Kashio M, Kimori Y, Matsuoka Y, Morimatsu H, Nabekura J, Tominaga M.
  Thermosensitive TRPV4 channels mediate temperature-dependent microglia movement.
  Proc Natl Acad Sci U S A, 118(17), e2012894118 DOI: 10.1073/pnas.2012894118.
• *Kashio M. *責任著者
  Thermosensation involving thermo-TRPs.
  Mol and Cell Endocrinol, 520:111089. DOI:https://doi.org/10.1016/j.mce.2020.111089

著書

• Kashio M (2024)
  Chapter 31; TRP channels in thermoregulation: therapeutic opportunities.
  TRP Channels as Therapeutic Targets: Advances in basic science and clinical use (2nd edition). Elsevier. (Arpad Szallasi, editor).
  https://doi.org/10.1016/B978-0-443-18653-0.00025-3
• Kashio M and * Tominaga M (2017)
  Redox-Sensitive TRP Channels: TRPA1 and TRPM2.
  Redox - Principles and Advanced Applications: Chapter 9, 203-223