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熊本大学
大学院生命科学研究部
環境分子保健学分野

〒862-0973
熊本市中央区大江本町5-1

misumi(*)kumamoto-u.ac.jp
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業績

感染症・免疫グループ/原著論文

2024

  • Watanabe A, Nagatomo M, Hirose A, Hikone Y, Kishimoto N, Miura S, Yasutake T, Abe T, Misumi S, Inoue M.
    Total Syntheses of Phorbol and 11 Tigliane Diterpenoids and Their Evaluation as HIV Latency-Reversing Agents.
    J Am Chem Soc. (2024) 146(12):8746-8756.

2023

  • Kuwazuru J, Suico MA, Omachi K, Kojima H, Kamura M, Kaseda S, Kawahara T, Hitora Y, Kato H, Tsukamoto S, Wada M, Asano T, Kotani S, Nakajima M, Misumi S, Sannomiya Y, Horizono J, Koyama Y, Owaki A, Shuto T, Kai H.
    CyclosporinA Derivative as Therapeutic Candidate for Alport Syndrome by Inducing Mutant Type IV Collagen Secretion.
    Kidney360 (2023) 4(7):909-917.
  • Tateishi H, Chinen T, Fukuda R, Radwan MO, Shimagaki K, Koga R, Masuda T, Okamoto Y, Sakamoto A, Misumi S, Otsuka M, Fujita M, Anraku K.
    HIV-1 Gag MA domain binds to cardiolipin in a binding mode distinct from virus assemble mediator PI(4,5)P2.
    Chem Biol Drug Des. (2023) e14401.
  • Aoki M, Aoki-Ogata H, Bulut H, Hayashi H, Takamune N, Kishimoto N, Tanaka H, Higashi-Kuwata N, Hattori SI, Das D, Venkateswara Rao K, Iwama K, Davis DA, Hasegawa K, Murayama K, Yarchoan R, Ghosh AK, Pau AK, Machida S, Misumi S, Mitsuya H.
    GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants.
    Sci Adv. (2023) 9(28):eadg2955.
  • Kawahara T, Ueda M, Kishimoto N, Yasutake T, Misumi S, Devkota HP, Wada M.
    Amamine, an isoquinoline alkaloid from the Kitasatospora sp. HGTA304.
    J Antibiot (2023) 76(10):623-625.
  • Yanagihara M, Kishimoto N, Nakahara K, Abe T, Miura S, Lin B, Fumimoto M, Haruta J, Misumi S, Arisawa M, Murai K.
    Synthesis and Biological Evaluation of Simplified Ansellone Analogues with Lipophilic Side Chains as HIV-Latency-Reversing Agents.
    Chemistry (2023) e202300677.
  • Higashi-Kuwata N, Tsuji K, Hayashi H, Bulut H, Kiso M, Imai M, Ogata-Aoki H, Ishii T, Kobayakawa T, Nakano K, Takamune N, Kishimoto N, Hattori SI, Das D, Uemura Y, Shimizu Y, Aoki M, Hasegawa K, Suzuki S, Nishiyama A, Saruwatari J, Shimizu Y, Sukenaga Y, Takamatsu Y, Tsuchiya K, Maeda K, Yoshimura K, Iida S, Ozono S, Suzuki T, Okamura T, Misumi S, Kawaoka Y, Tamamura H, Mitsuya H.
    Identification of SARS-CoV-2 Mpro inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2.
    Nat Commun. (2023) 25;14(1):1076.
  • Sakai A, Yamashita Y, Misumi S, Kishimoto N, Onodera R, Higashi T, Arima H, Motoyama K.
    Nanoparticles of folic acid-methyl-β-cyclodextrin (FA-MβCD)/adamantane-albumin exhibit enhanced antitumor activity compared with FA-MβCD alone.
    FEBS Open Bio. (2023) 13(2):233-245.

2022

  • Yanagihara M, Nakahara K, Kishimoto N, Abe T, Miura S, Misumi S, Sako M, Arisawa M, Murai K.
    Total Synthesis of Ansellone G and Phorbadione.
    J Org Chem. (2022) 16;87(24):16913-16917.
  • Tsuji K, Ishii T, Kobayakawa T, Higashi-Kuwata N, Azuma C, Nakayama M, Onishi T, Nakano H, Wada N, Hori M, Shinohara K, Miura Y, Kawada T, Hayashi H, Hattori SI, Bulut H, Das D, Takamune N, Kishimoto N, Saruwatari J, Okamura T, Nakano K, Misumi S, Mitsuya H, Tamamura H.
    Potent and biostable inhibitors of the main protease of SARS-CoV-2.
    iScience (2022) 18;25(11):105365.
  • Nishida T, Yokoyama R, Kubohira Y, Maeda Y, Takeo T, Nakagata N, Takagi H, Ishikura K, Yanagihara K, Misumi S, Kishimoto N, Ishitsuka Y, Kondo Y, Irie T, Soga M, Era T, Onodera R, Higashi T, Motoyama K.
    Lactose-Appended Hydroxypropyl-β-Cyclodextrin Lowers Cholesterol Accumulation and Alleviates Motor Dysfunction in Niemann-Pick Type C Disease Model Mice.
    ACS Appl Bio Mater. (2022) 5(5):2377-2388.
  • El-Desoky AHH, Eguchi K, Kishimoto N, Asano T, Kato H, Hitora Y, Kotani S, Nakamura T, Tsuchiya S, Kawahara T, Watanabe M, Wada M, Nakajima M, Watanabe T, Misumi S, Tsukamoto S.
    Isolation, Synthesis, and Structure-Activity Relationship Study on Daphnane and Tigliane Diterpenes as HIV Latency-Reversing Agents.
    J Med Chem. (2022) 24;65(4):3460-3472.
  • 三隅　将吾
    衛生と安全　感染症対策（総論）
    「ぶんせき」2022年1月号

2021

  • Kishimoto N, Okano R, Akita A, Miura S, Irie A, Takamune N., Misumi S.
    Arginyl-tRNA-protein transferase 1 contributes to governing optimal stability of the human immunodeficiency virus type 1 core.
    Retrovirology (2021) 18:30.
  • Omachi K, Kaseda S, Yokota T, Kamura M, Teramoto K, Kuwazuru J, Kojima H, Nohara H, Koyama K, Ohtsuki S, Misumi S, Takeo T, Nakagata N, Li JD, Shuto T, Suico MA, Miner JH, Kai H.
    Metformin ameliorates the severity of experimental Alport syndrome.
    Sci Rep. (2021) 11(1):7053.
  • Kishimoto N, Yamamoto K, Abe T, Yasuoka N, Takamune N, Misumi S.
    Glucose-dependent aerobic glycolysis contributes to recruiting viral components into HIV-1 particles to maintain infectivity.
    Biochem. Biophys. Res. Commun. (2021) 549:187-193.
  • Yanagihara M, Murai K, Kishimoto N, Abe T, Misumi S, Arisawa M.
    Total Synthesis and Biological Evaluation of the Potent HIV Latency-Reversing Agent Ansellone A and its Analogues.
    Org. Lett. (2021) 23(5):1720-1725.
  • Hattori SI, Higashi-Kuwata N, Hayashi H, Allu SR, Raghavaiah J, Bulut H, Das D, Anson BJ, Lendy EK, Takamatsu Y, Takamune N, Kishimoto N, Murayama K, Hasegawa K, Li M, Davis DA, Kodama EN, Yarchoan R, Wlodawer A, Misumi S, Mesecar AD, Ghosh AK, Mitsuya H.
    A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication.
    Nat Commun. (2021) 28;12(1):668.
  • Higashi-Kuwata N., Hayashi S., Kumamoto H., Ogata-Aoki H., Das D., Venzon D., Hattori S-i, Bulut H., Hashimoto M., Otagiri M., Takamune N., Kishimoto N., Davis D., Misumi S., Kakuni M., Tanaka Y., Mitsuya H.
    Identification of a Novel Long-Acting 4'-Modified Nucleoside Hepatitis B Virus Reverse Transcriptase Inhibitor
    J Hepatol. (2021) 74(5):1075-1086.

2020

  • 岸本 直樹、三隅 将吾
    感染性HIV-1粒子のプロテオーム解析から解き明かす宿主性タンパク質の多彩な機能
    Proteome Letters (2020) 5(2):33-43
  • Kishimoto N, Yamamoto K, Iga N, Kirihara C, Abe T, Takamune N, Misumi S.
    Alpha-enolase in viral target cells suppresses the human immunodeficiency virus type 1 integration
    Retrovirology (2020) 17: 31.
  • El-Desoky AHH, Eguchi K, Kato H, Kishimoto N, Misumi S, Watanabe T, Tsukamoto S.
    Chamaejasmins, cytotoxic guaiane sesquiterpenes from the root of Stellera chamaejasme L
    Fitoterapia (2020) 146:104714.
  • Hattori S-i, Higshi-Kuwata N,Raghavaiah J, Das D, Bulut H, Davis DA,Takamatsu Y, Matsuda K, Takamune N, Kishimoto N, Okamura T, Misumi S, Yarchoan R,Maeda K, Ghosh AK, Mitsuya H.
    GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection
    mBio. (2020) 11;e01833-20.
  • Isayama T*, Etoh H*, Kishimoto N, Takasaki T, Kuratani A, Ikuta T, Tatefuji T, Takamune N,Muneoka N, Takahashi Y, Misumi S.
    10-Hydroxydecanoic acid potentially elicits antigen-specific IgA responses
    Biol. Pharm. Bull. (2020)43(8):1202-1209.
    *These authors contributed equally.
  • Higashi T, Kogo T, Sato N, Hirotsu T, Misumi S, Nakamura H, Iohara D, Onodera R., Motoyama K, Arima H.
    Efficient Anticancer Drug Delivery for Pancreatic Cancer Treatment Utilizing Supramolecular Polyethylene-Glycosylated Bromelain
    ACS Appl. Bio Mater. (2020) 3,5,3005-3014

2019

  • Miki R, Honda I, Hamasaki R, Kawahara R, Soeda F, Shirasaki T, Misumi S, Takahama K.
    Effects of tipepidine on MK-801-induced cognitive impairment in mice
    Brain Res. (2019)1710:230-236.

2018

  • Elbashir SMI, Devkota HP, Wada M, Kishimoto N, Moriuchi M, Shuto T, Misumi S, Kai H, Watanabe T.
    Free radical scavenging, α-glucosidase inhibitory and lipase inhibitory activities of eighteen Sudanese medicinal plants
    BMC Complement Altern Med. (2018)18(1):282.
  • Mouree K.R., Kishimoto N, Iga N, Kirihara C, Yamamoto K, Takamune N, Misumi S.
    Virion-packaged pyruvate kinase muscle type 2 affects reverse transcription efficiency of human immunodeficiency virus type 1 by blocking virion recruitment of tRNALys3
    Biol. Pharm. Bull. (2018)41(4):612-618.
  • Dochi T, Akita A, Kishimoto N, Takamune N, Misumi S.
    Trametinib suppresses HIV-1 replication by interfering with the disassembly of human immunodeficiency virus type 1 capsid core
    Biochem. Biophys. Res. Commun. (2018) 495(2): 1846-1850.

2017

  • Aoki M, Hayashi H, Rao KV, Das D, Higashi-Kuwata N, Bulut H, Aoki-Ogata H, Takamatsu Y, Yedidi RS, Davis DA, Hattori S, Nishida N, Hasegawa K, Takamune N, Nyalapatla PR, Osswald HL, Jono H, Saito H, Yarchoan R, Misumi S, Ghosh AK, Mitsuya H.
    A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency.
    eLife 2017;6:e28020
  • Kishimoto N, Iga N, Yamamoto K, Takamune N, Misumi S.
    Virion-incorporated alpha-enolase suppresses the early stage of HIV-1 reverse transcription.
    Biochem. Biophys. Res. Commun. (2017) 484(2): 278-284.

2016

  • Hirotsu T, Higashi T, Abu Hashim II, Misumi S, Wada K, Motoyama K, Arima H.
    Self-assembly PEGylation Retaining Activity (SPRA) Technology via a Host-guest Interaction Surpassing Conventional PEGylation Methods of Proteins.
    Mol. Pharm. (2017) 14, 368-376.
  • Kishimoto N, Onitsuka-Kishimoto A, Iga N, Takamune N, Shoji S, Misumi S.
    The C-terminal domain of glyceraldehyde 3-phosphate dehydrogenase plays an important role in suppression of tRNALys3 packaging into human immunodeficiency virus type-1 particles.
    Biochem. Biophy. Rep. (2016) 8: 325-332.

2015

  • Ogawa M, Takemoto Y, Sumi S, Inoue D, Kishimoto N, Takamune N, Shoji S, Suzu S, Misumi S.
    ATP generation in a host cell in early-phase infection is increased by upregulation of cytochrome c oxidase activity via the p2 peptide from human immunodeficiency virus type 1 Gag
    Retrovirology (2015) 12:97.
  • Ohta H, Takamune N, Kishimoto N, Shoji S, Misumi S.
    N-myristoyltransferase 1 enhances human immunodeficiency virus replication through regulation of viral RNA expression level.
    Biochem. Biophys. Res. Commun. (2015) 463(4): 988-993.

2014

  • Harada K, Takamune N, Shoji S, Misumi S.
    Clearly different mechanisms of enhancement of short-lived Nef-mediated viral infectivity between SIV and HIV-1.
    Virol. J. (2014) 11:222.
  • Hirakane M, Taniguchi M, Yoshinaga S, Misumi S, Terasawa H.
    Expression and purification of mouse peptide ESP4 in Escherichia coli.
    Protein Expr. Purif. (2014) Apr;96:20-5.
  • Hayashi H, Takamune N, Nirasawa T, Aoki M, Morishita Y, Das D, Koh Y, Ghosh AK, Misumi S, Mitsuya H.
    Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir.
    Proc. Natl. Acad. Sci. U S A. (2014) Aug 19;111(33):12234-9.
  • Yamamoto M, Harada K, Shoji S, Misumi S, Takamune N.
    Identification of Essential cis Element in 5'UTR of Nef mRNA for Nef Translation.
    Curr. HIV Res. 2014;12(3):213-9.
  • Dochi T, Nakano T, Inoue M, Takamune N, Shoji S, Sano K, Misumi S.
    Phosphorylation of human immunodeficiency virus type 1 (HIV-1) capsid protein at serine 16, required for peptidyl-prolyl isomerase (Pin1)-dependent uncoating, is mediated by virion-incorporated extracellular signal-regulated kinase 2 (ERK2).
    J. Gen. Virol. (2014) 95, 1156-1166
  • Otsubo Y, Yashiro S, Nozaki K, Matsuura K, Kiyonaga K, Mitsumata R, Takahashi Y, Masuyama M, Muneoka A, Takamune N, Shoji S, Misumi S.
    Bovine alpha-2-HS-glycoprotein functions as a booster antigen for efficiently stimulating humoral immune responses to CCR5 and SIVmac239 envelope glycoprotein.
    Biochem. Biophys. Res. Commun. (2014) 443(1): 301-307.

2013

  • Kai H, MotomuraY, Saito S, Hashimoto K, Tatefuji T, Takamune N, Misumi S.
    Royal jelly enhances antigen-specific mucosal IgA response.
    Food Science & Nutrition (2013) 1(3): 222-227.
  • Kishimoto N, Onitsuka A, Sugimoto Y, Takamune N, Shoji S, Misumi S.
    Human tRNALys3 incorporation into HIV-1 virions was suppressed by glyceraldehyde 3-phosphate dehydrogenase.
    The Journal of AIDS Research (2013) 15(3): 158-163.

2012

  • Kishimoto N, Onitsuka A, Kido K, Takamune N, Shoji S, Misumi S.
    Glyceraldehyde 3-phosphate dehydrogenase negatively regulates human immunodeficiency virus type 1 infection. Retrovirology (2012) 9:107.
  • Takamune N, Irisaka Y, Yamamoto M, Harada K, Shoji S, Misumi S.
    Induction of extremely low protein expression level by fusion of C-terminal region of Nef.
    Biotechnol. Appl. Biochem. (2012) 59(3): 245-253.
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