環状オリゴ糖シクロデキストリンの生命科学領域への応用

環状オリゴ糖であるシクロデキストリンを生命科学および医薬に応用するための研究を様々な研究・医療機関と共同で展開しています。

～論文～

• Motoyama K, Toyodome H, Onodera R, Irie T, Hirayama F, Uekama K, Arima H, Involvement of Lipid Rafts of Rabbit Red Blood Cells in Morphological Changes Induced by Methylated beta-Cyclodextrins, Biological and Pharmaceutical Bulletin, 32, 700-705 (2009)
• Takeo T, Hoshii T, Kondo Y, Toyodome H, Arima H, Yamamura K, Irie T, Nakagata N, Methyl-β-cyclodextrin Improves Fertilizing Ability of C57BL/6 Mouse Sperm after Freezing and Thawing by Facilitating Cholesterol Efflux from the Cells, Biology of Reproduction, 78, 546-551 (2008).
• Karashima, K., Taniguchi, M., Nakamura, T., Takasaki, M., Matsuo, K., Irikura, M., Irie, T., Prolongation of intrathecal and sciatic nerve blocks using a complex of levobupivacaine with maltosyl-β-cyclodextrin in rats, Anesthesia and Analgesia, 104, 1121-1128 (2007)
• Motoyama, K., Arima, H., Toyodome, H., Irie, T., Hirayama, F., Uekama, K., Effect of 2,6-di-O-methyl-α-cyclodextrin on hemolysis and morphological change in rabbit's red blood cells, European Journal of Pharmaceutical Sciences, 29, 111-119 (2006)
• Okimoto, K., Tokunaga, Y., Ibuki, R., Irie, T., Uekama, K., Rajewski, R.A., Stella, V.J., Alicability of (SBE)7m-β-CD in controlled-porosity osmotic pump tablets (OPTs), International Journal of Pharmaceutics, 286, 81-88 (2004)
• Nagase, Y., Hirata, M., Arima, H., Tajiri, S., Nishimoto, Y., Hirayama, F., Irie, T., Uekama, K., Protective effect of sulfobutyl ether β-cyclodextrin on DY-9760e-induced hemolysis in vitro, Journal of Pharmaceutical Sciences, 91, 2382-2389 (2002)