Department of Analytical and Biophysical Chemistry

Division Environmental and Sociomedical Sciences
Great Department Environmental and Analytical Sciences
Website http://bunseki.pharm.kumamoto-u.ac.jp/
Staff
Professor Tadayuki Uno
unot@gpo.kumamoto-u.ac.jp
Assistant professor Yoshinobu Ishikawa
ishikawa@gpo.kumamoto-u.ac.jp
Instructor Yoshikazu Tomisugi
tomisugi@gpo.kumamoto-u.ac.jp
Research theme


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3D structure of a drug metabolizing enzyme CYP2C9 from human liver
Heme proteins bind gas molecules, and contribute mainly to the metabolism of drugs and chemical substances incorporated from the environment, and to the signal transduction in response to the environmental stresses. We reveal the relationship between environmental factors and biological responses in view of 3D structure of the heme proteins, affording chemical basis in developing efficient drugs. Based on the results obtained, new drugs/proteins are designed/engineered and further evaluated.