Research theme

We are currently investigating the molecular mechanisms of diseases such as cystic fibrosis, amyloidosis and cancer. Our main goal is to elucidate the factors involved in these diseases which could ultimately provide useful information to develop therapy. Specifically, we study

We are currently investigating the molecular mechanisms of diseases such as cystic fibrosis, amyloidosis and cancer. Our main goal is to elucidate the factors involved in these diseases which could ultimately provide useful information to develop therapy. Specifically, we study

1. the trafficking of CFTR and the role of the ER chaperones in the processing of CFTR,
2. the roles of Toll-like receptors in the pathogenesis of cystic fibrosis,
3. MEF, a member of the ETS transcription factor family, which is located in the chromosome Xq26.1, may be a candidate tumor suppressor gene in the X chromosome,
4. hyperthermia sensitizers,
5. the effects of metal ions on the stability of TTR, a protein whose variant causes familial amyloidotic polyneuropathy.

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Tumor formation was suppressed in nude mice injected with MEF-overexpressing cell line (Cancer Res. 62, 6579-6586, 2002).