We are searching for new potent drugs such as antiviral
antibiotics, antitumor drugs and other biologically-active
substances produced by microorganisms, especially
actinomycetes, and studying on their purifications,
structure elucidations, biosynthesis pathways and
action mechanisms. Among them, fattiviracins found
as antiviral agents are novel compounds effective
for herpes simplex virus type 1, varicella-zoster
virus, human immunodeficiency virus and influenza
virus. Fattiviracins will be in clinical use for
the treatment of viral diseases.
Topoisomerases are known to be the target enzymes
of antitumor drugs, since topoisomerases are critical
nuclear enzymes which regulate the three dimensional
structures of DNA. We have found 5 kinds of topo
inhibitors (antitumor drugs) having novel structures
from the cultures of microorganisms. Among them,
topostatin and isoaurostatin are the antitumor drugs
of new type which do not give DNA damage unlike
the conventional antitumor drugs. Now, we have tried
to find more effective antitumor drugs by carrying
out syntheses of the structure analogues of isoaurostatin. |
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School of Pharmacy
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