Division Integrated Medical and Pharmaceutical Sciences Great Department Pharmacotherapeutics Website http://seizai.pharm.kumamoto-u.ac.jp/index.html Staff Professor Hidetoshi Arima arimah@gpo.kumamoto-u.ac.jp Research Associate Keiichi Motoyama motoyama@kumamoto-u.ac.jp Research theme [Full size image] Proposed Inclusion Mode of Metoprolol/ γ -cyclodextrin Complex (molar ratio 2:1) Cyclodextrins (CyDs) are high-performance drug carriers, because of their ability to control the rate and time profiles of drug release, the ability to enhance the drug absorption across biological barriers, and the ability to deliver a drug to a targeted site. We are currently engaging in the research projects entitled "Design and Evaluation of CyD-based Drug Delivery Systems (DDS)" as follows: Development of colonic targeting systems using drug/CyD conjugates Development of DNA and siRNA delivery systems using dendrimer/CyD conjugates Control of solid-state properties of drugs by amorphous CyDs Improvement of pharmaceutical properties of peptide and protein drugs by hydrophilic CyDs Regulation of sepsis by CyD complexation Control of pharmacokinetic properties of anti-cancer drugs by CyD/liposome system Development of CyD-based nanoparticles for the novel drug targeting system.

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