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| Reduced apneic episodes
in low birth weight infants treated
with theophilline according to an individualized
protocol. (* p < 0.05 vs. standard protocol) |
|
Theophylline and doxapram are used to treat apnea
of prematurity, which occurs frequently to low birth
weight infants, although theophylline has no indication
and doxapram has a contraindication for the infants.
To provide individualized optimal dosage regimens
for these drugs, we are conducting clinical studies
to elucidate population pharmacokinetics of the
drugs in the infants, as a member of the Neonatal
Pharmacology Research Network. Acute respiratory
distress syndrome (ARDS) is a severe lung disease
with pulmonary vascular hyperpermeability, and has
a high mortality. However, there is little drug
useful for ARDS. Therefore, we are trying to find
candidates of drugs for the prevention and treatment
of ARDS and to elucidate the pathogenesis of the
lung injury, using oleic acid-induced lung injury,
which is an animal model of the disease. |
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School of Pharmacy
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