2014年

1.Furusato, A., Kato, H., Nehira, T., Eguchi, K., Kawabata, T., Fujiwara, Y., Losung, F., Mangindaan, R. E. P., de Voogd, N. J., Takeya, M., Yokosawa, H., Tsukamoto, S. Acanthomanzamines A-E with new manzamine frameworks from the marine sponge Acanthostrongylophora ingens. Org. Lett. accepted.

2.El-Desoky, A., Kato, H., Eguchi, K., Kawabata, T., Fujiwara, Y., Losung, F., Mangindaan, R. E. P., de Voogd, N., Takeya, M., Yokosawa, H., Tsukamoto, S. Acantholactam and pre-neo-kauluamine, manzamine-related alkaloids, from the Indonesian marine sponges, Acanthostrongylophora ingens. J. Nat. Prod. in press.

3.Kudo, Y., Kato, H., Rotinsulu, H., Losung, F., Mangindaan, R. E. P., de Voogd, N. J., Tsukamoto, S. Aaptoline A, a New Quinoline Alkaloid from the Marine Sponge Aaptos suberitoides. Heterocycles 88 (1), 591-594 (2014).

4.Sakai, E., Kato, H., Rotinsulu, H., Losung, F., Mangindaan, R. E. P., de Voogd, N. J., Yokosawa, H., Tsukamoto, S. Variabines A and B, New β-Carboline Alkaloids from the Marine Sponge Luffariella variabilis. J. Nat. Med. 68 (1), 215-219 (2014).

2013年

1.Imada, K., Sakai, E., Kato, H., Kawabata, T., Yoshinaga, S., Nehira, T., Terasawa, H., Tsukamoto, S. Reticulatins A and B and Hyrtioreticulin F from the Marine Sponge Hyrtios reticulatus. Tetrahedron 69 (34), 7051-7055 (2013).

2.Yamaguchi, M., Miyazaki, M., Kodrasov, M. P., Rotinsulu, H., Losung, F., Mangindaan, R. E. P., de Voogd, N. J., Yokosawa, H., Nicholson, B., Tsukamoto, S. Spongiacidin C, a Bromopyrrole Alkaloid from the Marine Sponge Stylissa massa, Functions as a USP7 Inhibitor. Bioorg. Med. Chem. Lett. 23 (13), 3884-3886 (2013).

3.Eguchi, K., Fujiwara, Y., Hayashida, A., Horlad, H., Kato, H., Rotinsulu, H., Losung, F., Mangindaan, R. E. P., de Voogd, N. J., Takeya, M., Tsukamoto, S. Manzamine A, a Marine-Derived Alkaloid, Inhibits Accumulation of Cholesterol Ester in Macrophages and Suppresses Hyperlipidemia and Atherosclerosis in vivo. Bioorg. Med. Chem. 21 (13), 3831-3838 (2013).

4.Nakamura, Y., Kato, H., Nishikawa, T., Iwasaki, N., Suwa, Y., Rotinsulu, H., Losung, F., Maarisit, W., Mangindaan, R. E. P., Morioka, H., Yokosawa, H., Tsukamoto, S. Siladenoserinols A-L: New Sulfonated Serinol Derivatives from a Tunicate as Inhibitors of p53-Hdm2 Interaction. Org. Lett. 15 (2), 322-325 (2013).

5.Sunderhaus, J. D., McAfoos, T. J., Finefield, J. M., Kato, H., Li, S., Tsukamoto, S., Sherman, D. H., Williams, R. M. Synthesis and Bioconversions of Notoamide T: A Biosynthetic Precursor to Stephacidin A and Notoamide B. Org. Lett. 15 (1), 22-25 (2013).

6.Kuwana, T., Miyazaki, M., Kato, H., Tsukamoto, S. Himeic Acids E-G, New 4-Pyridone Derivatives from a Culture of Aspergillus sp. Chem. Pharm. Bull. 61 (1), 105-107 (2013).

2012年

1.Ushiyama, S., Umaoka, H., Kato, H., Suwa, Y., Morioka, H., Rotinsulu, H., Losung, F., Mangindaan, R. E. P., de Voogd, N. J., Yokosawa, H., Tsukamoto, S. Manadosterols A and B, Sulfated Sterol Dimers Inhibiting Ubc13-Uev1A Interaction, Isolated from the Marine Sponge Lissodendryx fibrosa. J. Nat. Prod. 75 (8), 1495-1499 (2012).

2.Yamanokuchi, R., Imada, K., Miyazaki, M., Kato, H., Watanabe, T., Fujimuro, M., Saeki, Y., Yoshinaga, S., Terasawa,  H., Iwasaki, N., Rotinsulu, H., Losung, F., Mangindaan, R. E. P., Namikoshi, M., de Voogd, N. J., Yokosawa, H., Tsukamoto, S. Hirtioreticulins A-E: Indole Alkaloids Inhibiting the Ubiquitin-activating Enzyme, from the Marine Sponge Hyrtios reticulatus. Bioorg. Med. Chem. 20 (14), 4437-4442 (2012).

3.Li, S., Anand, K., Tran, H., Yu, F., Finefield, J. M., Sunderhaus, J. D., McAfoos, T. J., Tsukamoto, S., Williams, R. M., Sherma, D. H. Comparative Analysis of the Biosynthetic Systems for Fungal Bicyclo[2.2.2]diazaoctane Indole Alkaloids: the (+)/(-)-Notoamide, Paraherquamide and Malbrancheamide Pathways. MedChemComm 3 (8), 987-996 (2012).

4. Tamai, Y., Toume, K., Arai, M. A., Hayashida, A., Kato, H., Shizuri, Y., Tsukamoto, S., Ishibashi, M. Nonactin and Related Compounds Found in a Screening Program for Wnt Signal Inhibitory Activity. Heterocycles 84 (2), 1245-1250 (2012).

2011年

1.Kato, H., Nakamura, Y., Finefield, J. M., Umaoka, H., Nakahara, T., Williams, R. M., Tsukamoto, S. Study on the Biosynthesis of the Notoamides: Pinacol-type Rearrangement of Isoprenyl Unit in Deoxybrevianamide E and 6-Hydroxydeoxybrevianamide E. Tetrahedron Lett. 52 (51), 6923-6926 (2011).  

2.Nagasawa, Y., Kato, H., Rotinsulu, H., Mangindaan, R. E. P., de Voogd, N. J., Tsukamoto, S. Spironaamidine, a New Spiroquinone-containing Alkaloid from the Marine Sponge Leucetta microraphis. Tetrahedron Lett. 52 (41), 5342-5344 (2011).

3. Finefield, J. M., Kato, H., Greshock, T. J., Sherman, D. H., Tsukamoto, S., Williams, R. M. Biosynthetic Studies of the Notoamides: Isotopic Synthesis of Stephacidin A and Incorporation into Notoamide B and Sclerotiamide. Org. Lett. 13 (15), 3802-3805 (2011).

4.Finefield, J. M., Sherman, D. H., Tsukamoto, S., Williams, R. M. Studies on the Biosynthesis of the Notoamides: Synthesis of an Isotopomers of 6-Hydroxydeoxybrevianamide E and Biosynthetic Incorporation into Notoamide J. J. Org. Chem. 76 (15), 5954-5958 (2011).

5.Fujiwara, Y., Hayashida, A., Tsurushima, K., Nagai, R., Yoshitomi, M., Sakashita, N., Takeya, M., Tsukamoto, S., Ikeda, T. Triterpenes Isolated from Zizyphus Jujuba Inhibit the Foam Cell Formation in Macrophages. J. Agric. Food Chem. 59 (9), 4544-4552 (2011).

6.Finefield, J. M., Greshock, T. J., Sherman, D. H., Tsukamoto, S., Williams, R. M. Notoamide E: Biosynthetic incorporation into notoamides C and D in cultures of Aspergillus versicolor NRRL 35600. Tetrahedron Lett. 52 (16), 1987-1989 (2011).

7.Hirata, T., Kobayashi, T., Wada, A., Ueda, T., Fujikawa, T., Miyashita, H., Ikeda, T., Tsukamoto, S., Nohara, T. Anti-obesity Compounds in Green Leaves of Eucommia ulmoides. Bioorg. Med. Chem. Lett. 21 (6), 1786-1791 (2011).

8.Nagasawa, Y., Ueoka, R., Yamanokuchi, R., Horiuchi, N., Ikeda, T., Rotinsulu, H., Mangindaan, R. E. P., Ukai, K., Kobayashi, H., Namikoshi, M., Hirota, H., Yokosawa, H., Tsukamoto, S. Isolation of Salsolinol, a Tetrahydroisoquinoline Alkaloid, from the Marine Sponge Xestospongia cf. vansoesti as a Proteasome Inhibitor. Chem. Pharm. Bull. 59 (2), 287-290 (2011).

2010年

1.McAfoos, T. J., Tsukamoto, S., Sherman, D. H., Williams, R. M. Studies on the Biosynthesis of the Stephacidins and Notoamides. Total Synthesis of Notoamide S. Heterocycles 82 (1), 461-472 (2010).

2.Ding, Y., de Wet, J. R., Cavalcoli, J., Li, S., Greshock, T. J., Miller, K. A., Finefield, J. M., Sunderhaus, J. D., McAfoos, T. J., Tsukamoto, S., Williams, R. M., Sherman, D. H. Genome-based Characterization of Two Prenylation Steps in the Assembly of the Stephacidin and Notoamide Anticancer Agents in a Marine Aspergillus sp. J. Am. Chem. Soc. 132 (36), 12733-12740 (2010).

3.Tsukamoto, S., Umaoka, H., Yoshikawa, K., Ikeda, T., Hirota, H. Notoamide O, a Structurally Unprecedented Prenylated Indole Alkaloid, and Notoamides P-R from a Marine-derived Fungus, Aspergillus sp. J. Nat. Prod. 73 (8), 1438-1440 (2010).

4.El-Aasr, M., Fujiwara, Y., Takeya, M., Ikeda, T., Tsukamoto, S., Ono, M., Nakano, D., Okawa, M., Kinjo, J., Yoshimitsu, H., Nohara, T. Onionin A from Allium cepa Controls Macrophage Activation. J. Nat. Prod. 73 (7), 1306-1308 (2010).

5.Tsukamoto, S., Yamanokuchi, R., Yoshitomi, M., Sato, K., Ikeda, T., Rotinsulu, H., Mangindaan, R. E. P., de Voogd, N. J., van Soest, R. W. M., Yokosawa, H. Aaptamine, an Alkaloid from the Sponge Aaptos suberitoides, functions as a Proteasome Inhibitor. Bioorg. Med. Chem. Lett. 20 (11), 3341-3343 (2010).

6.Kapojos, M., Lee, J.-S., Oda, T., Nakazawa, T., Ukai, K., Mangindaan, R., Rotinsulu, H., Wewengkang, D., Tsukamoto, S., Kobayashi, H., Namikoshi, M. Two Unprecedented Cembrene-Type Terpenes from an Indonesian Soft Coral Sarcophyton sp. Tetrahedron 66 (3), 641-645 (2010).

Reviews

1.Tsukamoto, S., Yokosawa, H. Inhibition of the Ubiquitin-proteasome System by Natural Products for Cancer Therapy. Planta Med. 76 (11), 1064-1074 (2010).

2009年

1.Wang, W., Takahashi, O., Oda, T., Nakazawa, T., Ukai, K., Mangindaan, R. E., Rotinsulu, H., Wewengkang, D. S., Kobayashi, H., Tsukamoto, S., Namikoshi, M. Lissoclibadins 8-14, Polysulfur Dopamine-derived Alkaloids from the Colonial Ascidian Lissoclinum cf. badium. Tetrahedron 65 (46), 9598-9603 (2009).

2.Wang, W., Lee, J.-S., Nakazawa, T., Ukai, K., Mangindaan, R. E. P., Wewengkang, D. S., Rotinsulu, H., Kobayashi, H., Tsukamoto, S., Namikoshi, M. (25S)-Cholesten-26-oic Acid Derivatives from an Indonesian Soft Coral Minabea sp. Steroids 74 (9), 758-760 (2009).

3.Dalisay, D. S., Tsukamoto, S., Molinsli, T. F. Absolute Configuration of the α,ω-Bifunctionalized Sphingolipid Leucettamol A from Leucetta sp. by Deconvoluted Exciton Coupled CD. J. Nat. Prod. 72 (3), 353-359 (2009).

4.Miller, K. A., Tsukamoto, S., Williams, R. M. Asynmetric Total Syntheses of (+)- and (-)-Versicolamide B and Biosynthetic Implications. Nat. Chem. 1, 63-68 (2009).

5.Tsukamoto, S., Kato, H., Greshock, T. J., Hirota, H., Ohta, T. Williams, R. M. Isolation of Notoamides E, a Key Precursor in the Biosynthesis of Prenylated Indole Alkaloids in a Marine-derived fungus, Aspergillus sp. J. Am. Chem. Soc. 131 (11), 3834-3835 (2009).

6.Tsukamoto, S., Kawabata, T., Kato, H., Greshock, T. J., Hirota, H., Ohta, T., Williams, R. M. Isolation of Antipodal (-)-Versicolamide B and Notoamides L-N from a Marine-derived Aspergillus sp. Org. Lett. 11 (6), 1297-1300 (2009).

7.Nakahashi, A., Miura, N., Monde, K., Tsukamoto, S.  Stereochemical Studies of Hexylitaconic Acid, an Inhibitor of p53-HDM2 Interaction. Bioorg. Med. Chem. Lett. 19 (11), 3027-3030 (2009).

Review

1.Tsukamoto, S., Yokosawa, H. Targeting the proteasome-mediated proteolytic pathway, Expert Opin. Ther. Targets 13 (5), 605-621 (2009).

2008年

1.Tsukamoto, Kato, H., S., Samizo, M., Nojiri, Y., Ohnuki, H., Hirota, H., Ohta, T. Notoamides F to K: Prenylated Indole Alkaloids Isolated from a Marine derived Aspergillus sp. J. Nat. Prod. 71 (12), 2064-2067 (2008).

2.Tsukamoto, S., Takeuchi, T., Rotinsulu, H., Mangindaan, R. E. P., Soest, R. W. M. van, Ukai, K., Kobayashi, H., Namikoshi, M., Ohta, T., Yokosawa, H. Leucettamol A: A New Inhibitor of Ubc13-Uev1A Interaction Isolated from a Marine Leucetta aff. microrhaphis. Bioorg. Med. Chem. Lett. 18 (24), 6319-6320 (2008).

2007年

1.Tsukamoto, S., Kawabata, T., Kato, H., Ohta, T., Rotinsulu, H., Mangindaan, R. E. P., Soest, R. W. M. van, Ukai, K., Kobayashi, H., Namikoshi, M. Naamidines H and I: Cytotoxic Imidazole Alkaloids from the Indonesian Marine Sponge, Leucetta chagosensis, J. Nat. Prod. 70 (10), 1658-1660 (2007).

2.El-Beih, A. A., Kawabata, T., Koimaru, K., Ohta, T., Tsukamoto, S. Monodictyquinone A: A New Antimicrobial Anthraquinone from a Sea Urchin-Derived Fungus Monodictys sp., Chem. Pharm. Bull. 55 (7), 1097-1098 (2007).

3.El-Beih, A. A., Kato, H., Ohta, T., Tsukamoto, S. (3R,4aR,5S,6R)-6-Hydroxy-5-methylramulosin: A New Ramulosin Derivative from a Marine-derived Sterile Mycelium, Chem. Pharm. Bull. 55 (6), 953-954 (2007).

4.Greshock, T. J., Grubbs, A. W., Tsukamoto, S., Williams, R. M. Concise, Biomimetic Total Synthesis of Stephacidin A and Notoamide B. Angew. Chem. Int. Ed. 46 (13), 2262-2265 (2007).

5.Grubbs, W., Artman III, G. D., Tsukamoto, S., Williams, R. M.　Concise Total Synthesis of Notoamides C and D. Angew. Chem. Int. Ed. 46 (13), 2257-2261 (2007).

6.Kato, H., Yoshida, T., Tokue, T., Nojiri, Y., Hirota, H., Ohta, T., Williams, R. M., Tsukamoto, S. Notoamides A-D: New Prenylated Indole Alkaloids Isolated from a Marine-derived Fungus, Aspergillus sp. Angew. Chem. Int. Ed. 46 (13), 2254-2256 (2007).

7.El-Beih, A. A., Kato, H., Tsukamoto, S., Ohta, T. CYP3A4 Inhibitors Isolated from a Marine-derived Fungus, Penicillium species. J. Nat. Med. 61 (2), 175-177 (2007).

2006年

1.Tokue, T., Miura, S., Kato, H., Hirota, H., Ohta, T., Tsukamoto, S. Neurotrophic Sesterterpenes Isolated from a Marine Sponge, Spongia sp. Heterocycles 69 (1), 521-526 (2006).

2.Matsumura, K., Nagano, M., Tsukamoto, S., Kato, H., Fusetani, N. Effect of Emetine, a Protein Synthesis Inhibitor, on Larval Tail Resorption in the Ascidian Halocynthia roretzi. Sessile Organisms 23 (2), 95-98 (2006).

3.Tsukamoto, S., Yoshida, T., Hosono, H., Ohta, T., Yokosawa, H. Hexylitaconic acid: A new inhibitor of p53-HDM2 interaction isolated from a marine-derived fungus, Arthrinium sp. Bioorg. Med. Chem. Lett. 16 (1), 69-71 (2006).

Reviews

1.Tsukamoto, S. The Search for Inhibitors of the Ubiquitin-proteasome System from Natural Resources for Drug Development. J. Nat. Med. 60 (4), 273-278 (2006).

2.Tsukamoto, S., Yokosawa, H. Natural Products Inhibiting the Ubiquitin-proteasome Proteolytic Pathway, a Target for Drug Development. Curr. Med. Chem. 13 (7), 745-754 (2006).

2005年

1.Tsukamoto, S., Aburatani, M., Yoshida, T., Yamashita, Y., El-beih, A. A., Ohta, T. CYP3A4 Inhibitors Isolated from Licorice. Biol. Pharm. Bull. 28 (10), 2000-2002 (2005).

2.Tsukamoto, S., Wakana, T., Koimaru, K. Yoshida, T., Sato, M., Ohta, T. 7-Hydroxy-3-(4-hydroxybenzyl)chroman and Broussonin B: Neurotrophic Compounds, Isolated from Anemarrhena asphodeloides BUNGE, Function as Proteasome Inhibitors. Biol. Pharm. Bull. 28 (9), 1798-1800 (2005).

3.Tsukamoto, S., Koimaru, K., Ohta, T. Secomycalolide A: A New Proteasome Inhibitor Isolated from a Marine Sponge of the Genus Mycale. Mar. Drugs 3 (2), 29-35 (2005).

4.Tsukamoto, S., Aburatani, M., Ohta, T. Isolation of the Potent CYP3A4 Inhibitors from the Black Cohosh (Cimifunga racemosa). eCAM 2 (2), 223-226 (2005) .

5.Tsukamoto, S., Yamashita, Y., Ohta, T. New Cytotoxic and Antibacterial Compounds Isolated from the Sea Hare, Aplysia kurodai. Mar. Drugs 3 (2), 22-28 (2005).

6.Tsukamoto, S., Hirota, H., Imachi, M., Fujimuro, M., Onuki, H., Ohta, T., Yokosawa, H. Himeic Acid A: A New Ubiquitin-Activating Enzyme Inhibitor Isolated from a Marine-Derived Fungus, Aspergillus sp. Bioorg. Med. Chem. Lett. 15 (1), 191-194 (2005).

2004年

1.Tsukamoto, S., Tomise, K., Aburatani, M., Onuki, H., Hirota, H., Ishiharajima, E., Ohta, T. Isolation of Cytochrome P450 Inhibitors from Strawberry Fruit, Fragaria ananassa Duch. cv. Tochiotome. J. Nat. Prod. 67 (11), 1839-1841 (2004).

2.Tsukamoto, S., Yamashita, Y., Yoshida, T., Ohta, T. Parguerol and Isoparguerol Isolated from the Sea Hare, Aplysia kurodai, Induce Neurite Outgrowth in PC-12 Cells. Mar. Drugs 2 (4), 170-175 (2004).

3.Tsukamoto, S., Yamashita, K., Tane, K., Kizu, R., Ohta, T., Matsunaga, S., Fusetani, N., Kawahara, H., Yokosawa, H. Girolline, an Antitumor Compound Isolated from a Sponge, Induces G2/M Cell Cycle Arrest and Accumulation of Polyubiquitinated p53. Biol. Pharm. Bull. 27 (5), 699-701 (2004)

4.Tsukamoto, S., Miura, S., Yamashita, Y., Ohta, T. Aspermytin A: A New Neurotrophic Polyketide Isolated from a Marine-derived Fungus of the Genus Aspergillus. Bioorg. Med. Chem. Lett. 14 (2), 417-420 (2004).

2003年

1.Tsukamoto, S., Macabalang, A. D., Nakatani, K., Obara, Y., Nakahata, N., Ohta, T. Tricholomalides A-C: New Neurotrophic Diterpenes from the Mushroom Tricholoma sp. J. Nat. Prod. 66 (12), 1578-1581 (2003).

2.Tsukamoto, S., Tatsuno, M., van Soest, R. W. M., Yokosawa, H., Ohta, T. New Polyhydroxy Sterols: Proteasome Inhibitors from a Marine Sponge Acanthodendrilla sp. J. Nat. Prod. 66 (9), 1181-1185 (2003).

3.Tsukamoto, S., Miura, S., van Soest, R. W. M., Ohta, T. Three New Cytotoxic Sesterterpenes from a Marine Sponge Spongia sp. J. Nat. Prod. 66 (3), 438-440 (2003).

2002年

1.Ohta, T., Miyamoto, Y., Maruyama, T., Kiuchi, F., Tsukamoto, S. Localization and Contents of Paradisins, the Most Potent CYP3A4 Inhibitors, in a Grapefruit Citrus paradisii and Grapefruit Juice. Nat. Med. 56 (6), 264-267 (2002).

2.Ohta, T., Maruyama, T., Nagahashi, K., Miyamoto, Y., Hosoi, S., Kiuchi, F., Yamazoe, Y., Tsukamoto, S. Paradisin C: A New CYP3A4 Inhibitor from Grapefruit Juice. Tetrahedron 58 (33), 6631-6635 (2002).

3.Tsukamoto, S., Tomise, K., Miyakawa, K., Cha, B.-C., Abe, T., Hamada, T., Hirota, H., Ohta, T. CYP3A4 Inhibitory Activity of New Bisalkaloids Dipiperamides D and E and Cognate Alkaloids from the White Pepper. Bioorg. Med. Chem. 10 (9), 2981-2985 (2002).

4.Ohta, T., Nagahashi, M., Hosoi, S., Tsukamoto, S. Dihydroxybergamottin Caproate as a Potent and Stable CYP3A4 Inhibitor. Bioorg. Med. Chem. 10 (4), 969-973 (2002).

5.Tsukamoto, S., Cha, B.-C., Ohta, T. Dipiperamides A, B, and C: bisalkaloids from the white pepper Piper nigrum inhibiting CYP3A4 activity. Tetrahedron 58 (9), 1667-1671 (2002).

6.Tsukamoto, S., Macabalang, A. D., Abe, T., Hirota, H., Ohta, T. Thelephorin A: a new radical scavenger from the mushroom Thelephora vialis. Tetrahedron 58 (6), 1103-1105 (2002).

2001年

1.Tsukamoto, S., Tane, K., Ohta, T., Matsunaga, S., Fusetani, N., van Soest, R. W. M. Four New Bioactive Pyrrole-derived Alkaloids from the Marine Sponge Axinella brevistyla. J. Nat. Prod. 64 (12), 1576-1578 (2001).

Book

1.Tsukamoto, S., Kato, H., Hirota, H., Fusetani, N. Lumichrome is a Putative Intrinsic Substance Inducing Larval Metamorphosis in the Ascidian Halocynthia roretzi. The Biology of Asicidians; Sawada, H., Yokosawa, H., Lambert, C. C. Eds.; Springer-Verlag. Tokyo: Tokyo; pp 335-340 (2001).