分子修飾の代謝に関する研究
  1. Improving the pharmacokinetic and pharmacodynamic properties of drug chemical conversion to a chimera drug
    M. Otagiri, T. Imai, A. Fukuhara
    J. Control. Release, 62, 223-229 (1999)
  2. Characterization of urinary metabolites of a new benzofuroquinoline derivative, 3,9-bis(N,N-dimethyl carbamoyloxy)-5H-benzofuro[3,2-c]-quinoline-6-one (KCA-098), in dogs.
    T.Yamada, A. Yamamoto, M. Fujioka, M. Miyagi, N. Saito, T. Imai, M.Otagiri
    Pharmazie, 54 (9), 672-677 (1999)
  3. In vitro identification of the human cytochrome P-450 enzymes involved in the N-demethylation of azelastine
    T. Imai, M. Taketani, T.Suzu, K. Kusube, M. Otagiri
    Drug Metab. Dispos., 27(8) 942-946 (1999).
  4. Characterization of Esterase Involved in the Stereoselective Hydrolysis of Ester-Type Prodrugs of Propranolol in Rat Liver and Plasma.
    Y. Yoshigae, T. Imai, M. Taketani and M. Otagiri
    Chirality, 11 (1) 10-13 (1999).
  5. Species Differences in Stereoselective Hydrolase Activity in Intestinal Mucosa.
    Y. Yoshigae, T. Imai, A. Horita, H. Matsukane, M. Otagiri
    Pharm. Res., 15(4) 626-631 (1998)
  6. Species Differences in the Disposition of Propranolol Prodrugs Derived from Hydrolase Activity in Intestinal Mucosa.
    Y. Yoshigae, T Imai, T. Aso and M. Otagiri
    Life Sciences, 62(14) 1231-1241 (1998)
  7. Stereospecific Activity and Nature of Metabolizing Esterases for Propranolol Prodrug in Hairless Mouse Skin, Liver and Plasma.
    S. Ahmed, T. Imai, Y. Yoshigae and M. Otagiri
    Life Sciences, 61(19), 1879-1887 (1997).
  8. Stereoselectivity in Cutaneous Hydrolysis and Transdermal Transport of Propranolol Prodrug.
    S. Ahmed, T. Imai, M. Otagiri
    Enantiomer, 2(3-4) 181-191 (1997).
  9. Species Differences for Stereoselective Hydrolysis of Propranolol Prodrugs in Plasma and Liver.
    Y. Yoshigae, T. Imai, A. Horita and M. Otagiri
    Chirality, 9(7), 661-666 (1997).
  10. Alteration of Pharmacokinetics and Nephrotoxicity of Cisplatin by Alginates
    T. Imai, K. Fujii, S. Shiraishi, M. Otagiri
    J. Pharm. Sci., 86(2) 244-247 (1997).

Caco2膜透過性に関する研究
  1. Simultaneous Use of Sodium Deoxycholate and Dipotassium Glysyrrhizinate Enhances the Cellular Transport of Poorly Absorbed Compounds across Caco-2 Cell Monolayers.
    M. Sakai, T. Imai, H. Ohtake, H. Azuma and M. Otagiri
    J. Pharm. Pharmacol., 51(1) 27-33 (1999).
  2. In Vitro and In Vivo Evaluation of the Enhancing Activity of Glycyrrhizin on the Intestinal Absorption of Drugs
    T. Imai, M. Sakai, H. Ohtake, H. Azuma and M. Otagiri
    Pharm. Res., 16(1) 80-86 (1999).
  3. Cytotoxicity of Absorption Enhancers in Caco-2 Cell Monolayers.
    M. Sakai, Teruko Imai, H. Ohtake and M. Otagiri
    J .Pharm. Pharmacol., 50 (10) 1101-1108 (1998) .
  4. Effects of Absorption Enhaners on Cytoskeletal Actin Filaments in Caco-2 Cell Monolayers.
    M.Sakai, T. Imai, H.Ohtake, H.Azuma and M. Otagiri
    Life. Sci., 63(1) 45-54 (1998).
  5. Effects of Absorption Enhancers on the Transport of Model Compounds in Caco-2 Cell Monolayers: Assessment by Confocal Laser Scanning Microscopy.
    M. Sakai, T. Imai, H. Ohtake, H. Azuma and M. Otagiri
    J. Pharm. Sci., 86(7) 779-785 (1997).

製剤設計に関する研究
  1. Comparison of the pharmaceutical properties of sustained-release gel beads prepared by alginate having different molecular size with commercial sustained-release tablet.
    T. Imai, C. Kawasaki, T. Nishiyama, M. Otagiri
    Pharmazie, 55, 218-222 (2000).
  2. A strategy for the immediate-release of indomethacin from a sustained-release preparation using a chitosan hydrolysate.
    T. Imai, S. Shiraishi, M. Otagiri
    S.T.P. Pharm. Sci., 10(1) 57-62 (2000).
  3. Effect of grinding with hydroxypropyl cellulose on the dissolution and particle size of a poorly water-soluble drug.
    T. Yamada, N. Saito, T. Imai, M. Otagiri
    Chem. Pharm. Bull., 47(9), 1311-1313 (1999).
  4. Casein Hydrolysate as a Rapid and/or Enteric Dissolving Additive for Oral Drugs.
    T. Imai, T. Nishiyama, M. Shameem and M. Otagiri
    Pharm. Develop. Tech., 3(2) 225-232 (1998).
  5. Mutual Effect of Egg Albumin and Fatty Acids on Bioavailability of dl-?-Tocopherol.
    T. Imai, K. Nohdomi, M. Shameem, H. Matsumoto, T. Satoh and M. Otagiri
    Int. J. Pharm., 155(1) 45-52 (1997).